专题：Parkinson's Disease Mechanisms and Treatments

This cluster of papers explores the pathophysiology, clinical features, diagnosis, genetic risk factors, and management of Parkinson's disease. It delves into the role of a-synuclein, neurodegeneration, dopaminergic neurons, oxidative stress, and mitochondrial dysfunction in the development and progression of the disease. Additionally, it discusses the non-motor symptoms and Lewy body pathology associated with Parkinson's disease.
最新文献
The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging

article Full Text OpenAlex

Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2

article Full Text OpenAlex

Current and Emerging Therapeutic Targets for Essential Tremor: A Critical Appraisal of Recent Preclinical and Clinical Studies

review Full Text OpenAlex

DEFINING ‘OFF’ TIME IN DEVICE-AIDED THERAPY CRITERIA FOR PARKINSON’S DISEASE: GAPS AND OPPORTUNITIES

article Full Text OpenAlex

Neuroimaging and plasma biomarker differences and commonalities in Lewy body dementia subtypes

article Full Text OpenAlex

Safety and efficacy of trehalose in amyotrophic lateral sclerosis (HEALEY ALS Platform Trial): an adaptive, phase 2/3, double-blind, randomised, placebo-controlled trial

article Full Text OpenAlex

Misfolded α‐synuclein co‐occurrence with Alzheimer's disease proteinopathy

article Full Text OpenAlex

Impact of COVID‐19 on long‐term outcomes in Parkinson's disease

article Full Text OpenAlex

Mitochondrial Dysfunction in Genetic and Non-Genetic Parkinson’s Disease

review Full Text OpenAlex

Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery

review Full Text OpenAlex

近5年高被引文献
Parkinson's disease

review Full Text OpenAlex 2526 FWCI70.452

Challenges in the diagnosis of Parkinson's disease

review Full Text OpenAlex 1219 FWCI32.223

Autophagy in major human diseases

review Full Text OpenAlex 1207 FWCI42.033

Molecular mechanisms and physiological functions of mitophagy

review Full Text OpenAlex 1065 FWCI37.078

Parkinson disease-associated cognitive impairment

review Full Text OpenAlex 915 FWCI24.9

Inflammation and immune dysfunction in Parkinson disease

review Full Text OpenAlex 906 FWCI44.084

Biomarkers for neurodegenerative diseases

review Full Text OpenAlex 822 FWCI23.137

Amyotrophic lateral sclerosis

review Full Text OpenAlex 678 FWCI32.731

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis

review Full Text OpenAlex 572 FWCI18.402

Global Trends in the Incidence, Prevalence, and Years Lived With Disability of Parkinson's Disease in 204 Countries/Territories From 1990 to 2019

article Full Text OpenAlex 542 FWCI50.047