专题：Parkinson's Disease Mechanisms and Treatments

This cluster of papers explores the pathophysiology, clinical features, diagnosis, genetic risk factors, and management of Parkinson's disease. It delves into the role of a-synuclein, neurodegeneration, dopaminergic neurons, oxidative stress, and mitochondrial dysfunction in the development and progression of the disease. Additionally, it discusses the non-motor symptoms and Lewy body pathology associated with Parkinson's disease.
最新文献
Intestinal macrophages modulate synucleinopathy along the gut–brain axis

article Full Text OpenAlex

The Prokineticin system is downregulated in idiopathic rapid eye movement sleep behavior disorder: evidence from olfactory neurons

article Full Text OpenAlex

GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis

article Full Text OpenAlex

Exploring Parkinson's disease: an insightful overview

book-chapter Full Text OpenAlex

Systematic profiling reveals distinct senescence signatures and regulators across human brain cell types

article Full Text OpenAlex

Pathological and Molecular Insights into the Early Stage of Multiple System Atrophy

article Full Text OpenAlex

The gut microbiome, systemic inflammation, and autoimmunity in Parkinson's disease

review Full Text OpenAlex

Long‐term safety and efficacy of lecanemab in early Alzheimer's disease: Results from the clarity AD open‐label extension study

article Full Text OpenAlex

Supplementation with short-chain fatty acids and a prebiotic improves clinical outcome in Parkinson’s disease: a randomized double-blind prospective study

article Full Text OpenAlex

Clinical, Biological, and Functional Connectivity Profile of Patients With De Novo Parkinson Disease Who Are APOE ε4 Carriers

article Full Text OpenAlex

近5年高被引文献
Inflammation and immune dysfunction in Parkinson disease

review Full Text OpenAlex 1231 FWCI144.1416

Amyotrophic lateral sclerosis

review Full Text OpenAlex 932 FWCI105.8949

The pathogenesis of Parkinson's disease

review Full Text OpenAlex 729 FWCI274.1596

The epidemiology of Parkinson's disease

review Full Text OpenAlex 720 FWCI240.8823

The Movement Disorder Society Criteria for the Diagnosis of Multiple System Atrophy

review Full Text OpenAlex 711 FWCI81.3578

The mitophagy pathway and its implications in human diseases

review Full Text OpenAlex 652 FWCI142.0143

Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction

review Full Text OpenAlex 640 FWCI132.9972

Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study

article Full Text OpenAlex 627 FWCI130.0787

Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

article Full Text OpenAlex 579 FWCI87.303

Oxidative Stress and Antioxidants in Neurodegenerative Disorders

review Full Text OpenAlex 547 FWCI114.0273