专题：Osteoarthritis Treatment and Mechanisms

This cluster of papers focuses on the pathophysiology of osteoarthritis, with an emphasis on cartilage degradation, inflammation, joint mechanics, and potential therapeutic approaches such as cartilage regeneration using mesenchymal stem cells. It also covers the role of chondrocytes, matrix metalloproteinases, and synovitis in the development and progression of osteoarthritis.
最新文献
Conditioned medium of mesenchymal stem cells: dual anti-inflammatory and analgesic effects in rheumatoid arthritis model

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Acid neutralization and metal-phenolic nanomedicine on-demand release microspheres for reversing cartilage degeneration

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Reliable pain and function outcomes but limited sport performance after high tibial osteotomy for medial knee osteoarthritis in the grey zone between osteotomy and unicompartmental replacement

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A therapeutic-grade purified exosome system alleviates osteoarthritis by regulating autophagy through the BCL2–Beclin1 axis

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Hierarchical crack-resistant, tissue-mimetic hydrogels enabled by progressive nanocrystallization of anisotropic polymer networks

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Tuning Pluronic Hydrogel Properties via Ionic Strength and Hyaluronic Acid for Optimized Rheology and Drug Delivery Performances

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Osteoarthritis as a systemic disease

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Curcumin controls the senescence of adipose-derived mesenchymal stem cells via the FoxO3/autophagy signaling pathway to enhance joint homeostasis for osteoarthritis therapy

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Interferon-γ-Induced Mesenchymal Stem Cell Exosomes Attenuate Chondrocyte Senescence and Osteoarthritis Progression by Hsp70

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Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration

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近5年高被引文献
Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021

article Full Text OpenAlex 1454 FWCI373.9325

Prevalence Trends of Site‐Specific Osteoarthritis From 1990 to 2019: Findings From the Global Burden of Disease Study 2019

article Full Text OpenAlex 1083 FWCI174.1832

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

review Full Text OpenAlex 966 FWCI246.6793

Synovial inflammation in osteoarthritis progression

review Full Text OpenAlex 895 FWCI141.9998

Obesity, Inflammation, and Immune System in Osteoarthritis

review Full Text OpenAlex 414 FWCI59.866

Current understanding of osteoarthritis pathogenesis and relevant new approaches

review Full Text OpenAlex 364 FWCI28.799

Inflammaging and Osteoarthritis

review Full Text OpenAlex 357 FWCI55.6762

AAOS Clinical Practice Guideline Summary: Management of Osteoarthritis of the Knee (Nonarthroplasty), Third Edition

article Full Text OpenAlex 318 FWCI62.3484

Knee Osteoarthritis: Epidemiology, Pathogenesis, and Mesenchymal Stem Cells: What Else Is New? An Update

review Full Text OpenAlex 313 FWCI79.7891

Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits

article Full Text OpenAlex 302 FWCI53.0066