专题：Osteoarthritis Treatment and Mechanisms

This cluster of papers focuses on the pathophysiology of osteoarthritis, with an emphasis on cartilage degradation, inflammation, joint mechanics, and potential therapeutic approaches such as cartilage regeneration using mesenchymal stem cells. It also covers the role of chondrocytes, matrix metalloproteinases, and synovitis in the development and progression of osteoarthritis.
最新文献
Cellular senescence and other age-related mechanisms in skeletal diseases

review Full Text OpenAlex

Burden of knee osteoarthritis in China and globally: 1990–2045

article Full Text OpenAlex

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

article Full Text OpenAlex

Injectable oxidized hyaluronic acid/quaternized chitosan hydrogel encapsulated with diacerein microsphere for improved osteoarthritis treatment

article Full Text OpenAlex

A phase 1 clinical trial shows safe, sustained, AAV-mediated expression of IL-1Ra in the human osteoarthritic knee joint

article Full Text OpenAlex

Low-Dose Methotrexate for the Treatment of Inflammatory Knee Osteoarthritis

letter Full Text OpenAlex

Effect of intraarticular human umbilical cord mesenchymal stem cells transplantation on cartilage degradation and matrix metalloproteinases in OA rat model

article Full Text OpenAlex

Adaptive hydrogel loaded with pre-coordinated stem cells for enhanced osteoarthritis therapy

article Full Text OpenAlex

Global, regional, and national burden of osteoarthritis from 1990 to 2021 and projections to 2035: A cross-sectional study for the Global Burden of Disease Study 2021

article Full Text OpenAlex

Osteocyte-derived extracellular vesicles mediate the bone-to-cartilage crosstalk and promote osteoarthritis progression

article Full Text OpenAlex

近5年高被引文献
Diagnosis and Treatment of Hip and Knee Osteoarthritis

review Full Text OpenAlex 1594 FWCI60.073

Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021

article Full Text OpenAlex 826 FWCI315.911

Osteoarthritis of the Knee

review Full Text OpenAlex 775 FWCI29.283

Prevalence Trends of Site‐Specific Osteoarthritis From 1990 to 2019: Findings From the Global Burden of Disease Study 2019

article Full Text OpenAlex 772 FWCI181.634

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

review Full Text OpenAlex 697 FWCI69.485

Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee

review Full Text OpenAlex 648 FWCI16.441

Synovial inflammation in osteoarthritis progression

review Full Text OpenAlex 638 FWCI36.907

Epidemiology of osteoarthritis

review Full Text OpenAlex 629 FWCI21.257

The burden of OA-health services and economics

article Full Text OpenAlex 514 FWCI42.715

Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis

review Full Text OpenAlex 442 FWCI16.246