专题：DNA Repair Mechanisms

This cluster of papers focuses on the molecular mechanisms of the DNA damage response, including DNA repair pathways, genomic instability, the role of ATM and ATR kinases, homologous recombination, cell cycle checkpoints, and their implications in cancer biology. It also explores the involvement of histone H2AX and chromatin in maintaining genome stability.
最新文献
NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

article Full Text OpenAlex

An integrative structural study of the human full-length RAD52 at 2.2 Å resolution

article Full Text OpenAlex

The human ATAD5 has evolved unique structural elements to function exclusively as a PCNA unloader

article Full Text OpenAlex

Interplay between altered metabolism and DNA damage and repair in ovarian cancer

review Full Text OpenAlex

CS proteins and ubiquitination: orchestrating DNA repair with transcription and cell division

review Full Text OpenAlex

Ataxia-Telangiectasia Mutated (ATM) gene signaling pathways in human cancers and their therapeutic implications

review Full Text OpenAlex

Clustered DNA Damage and its Complexity: Tracking the History

article Full Text OpenAlex

KAT6A Condensates Impair PARP1 Trapping of PARP Inhibitors in Ovarian Cancer

article Full Text OpenAlex

Comprehensive analysis of hub genes associated with cisplatin-resistance in ovarian cancer and screening of therapeutic drugs through bioinformatics and experimental validation

article Full Text OpenAlex

Germline BARD1 variants predispose to mesothelioma by impairing DNA repair and calcium signaling

article Full Text OpenAlex

近5年高被引文献
Adjuvant Olaparib for Patients with BRCA1 - or BRCA2 -Mutated Breast Cancer

article Full Text OpenAlex 1483 FWCI124.1204884

Cell cycle control in cancer

review Full Text OpenAlex 1289 FWCI98.85609845

The central role of DNA damage in the ageing process

review Full Text OpenAlex 805 FWCI59.20218334

DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

review Full Text OpenAlex 727 FWCI48.96127848

Targeting DNA damage response pathways in cancer

review Full Text OpenAlex 693 FWCI103.23253374

Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation

article Full Text OpenAlex 446 FWCI35.01414138

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

article Full Text OpenAlex 442 FWCI37.94900068

Understanding and overcoming resistance to PARP inhibitors in cancer therapy

review Full Text OpenAlex 438 FWCI33.86057243

Talazoparib plus enzalutamide in men with first-line metastatic castration-resistant prostate cancer (TALAPRO-2): a randomised, placebo-controlled, phase 3 trial

article Full Text OpenAlex 418 FWCI99.3155571

Somatic mutation rates scale with lifespan across mammals

article Full Text OpenAlex 412 FWCI55.47025848