专题：DNA Repair Mechanisms

This cluster of papers focuses on the molecular mechanisms of the DNA damage response, including DNA repair pathways, genomic instability, the role of ATM and ATR kinases, homologous recombination, cell cycle checkpoints, and their implications in cancer biology. It also explores the involvement of histone H2AX and chromatin in maintaining genome stability.
最新文献
Bora bridges Aurora-A activation and substrate recognition of PLK1

article Full Text OpenAlex

Dps binds and protects DNA in starved Escherichia coli with minimal effect on chromosome accessibility, dynamics, and organization

article Full Text OpenAlex

Sex-specific landscapes of crossover and non-crossover recombination in coppery titi monkeys ( Plecturocebus cupreus )

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Rad51 determines pathway usage in post-replication repair

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Replication-associated base excision repair/single-strand break repair regulates PARG inhibitor response via the PRMT1/PRMT5/ATR axis

article Full Text OpenAlex

The alternative lengthening of telomeres pathway through a DNA repair lens: mechanism and therapeutic opportunities

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A multiplicative behavioral model of DNA replication initiation in cells

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Mutual, spatially limited control of meiotic DNA break formation by Mre11–Rad50–Nbs1 DNA repair complex and Tel1 (ATM) protein kinase

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Human acrocentric chromosome short arm de novo mutation and recombination

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Genome-wide screen reveals dependence of break induced replication on several distinct checkpoints

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近5年高被引文献
Targeting DNA damage response pathways in cancer

review Full Text OpenAlex 772 FWCI75.3405

Talazoparib plus enzalutamide in men with first-line metastatic castration-resistant prostate cancer (TALAPRO-2): a randomised, placebo-controlled, phase 3 trial

article Full Text OpenAlex 459 FWCI107.3694

Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis

review Full Text OpenAlex 442 FWCI36.4703

Somatic mutation rates scale with lifespan across mammals

article Full Text OpenAlex 438 FWCI39.5929

Chemotherapy Side-Effects: Not All DNA Damage Is Equal

review Full Text OpenAlex 414 FWCI147.5287

Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

article Full Text OpenAlex 411 FWCI40.2862

NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

article Full Text OpenAlex 406 FWCI97.8733

Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1

article Full Text OpenAlex 396 FWCI33.9169

Hallmarks of DNA replication stress

review Full Text OpenAlex 390 FWCI30.6206

Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids

review Full Text OpenAlex 361 FWCI31.0846