专题：DNA Repair Mechanisms

This cluster of papers focuses on the molecular mechanisms of the DNA damage response, including DNA repair pathways, genomic instability, the role of ATM and ATR kinases, homologous recombination, cell cycle checkpoints, and their implications in cancer biology. It also explores the involvement of histone H2AX and chromatin in maintaining genome stability.
最新文献
Polymerase theta (Polθ) and cancer: Role in tumor progression and potential as a therapeutic target

review Full Text OpenAlex

ZDHHC20-mediated S-palmitoylation of KAP1/TRIM28 promotes DNA damage repair

article Full Text OpenAlex

Meiotic progression in multinuclear mouse spermatocytes without the spindle pole clustering motor protein KIFC1 or cytokinesis forms single-cell late-stage spermatids

article Full Text OpenAlex

Novel Cross-Cancer Hub Genes in Doxorubicin Resistance Identified by Transcriptional Mapping

article Full Text OpenAlex

Overcoming natural replication barriers formed by DNA structures and the role of repositioning to the nuclear periphery

article Full Text OpenAlex

Mitotic recombination events and single-base mutations induced by ultraviolet light in G1-arrested yeast cells

article Full Text OpenAlex

Distinct roles of RECQL5 in RAD51-mediated fork reversal and transcription elongation

article Full Text OpenAlex

DirectHRD enables sensitive scar-based classification of homologous recombination deficiency

article Full Text OpenAlex

A Balancing Act: Thymine DNA Glycosylase Combines Sequence and Rotational Preferences To Define Lesion Excision in the Nucleosome Core Particle

article Full Text OpenAlex

Exploring Rad51 inhibition mechanisms of B02 and IBR2 and identifying prospective drug candidates for Rad51: A computational investigation

article Full Text OpenAlex

近5年高被引文献
Targeting DNA damage response pathways in cancer

review Full Text OpenAlex 728 FWCI106.95665111

Talazoparib plus enzalutamide in men with first-line metastatic castration-resistant prostate cancer (TALAPRO-2): a randomised, placebo-controlled, phase 3 trial

article Full Text OpenAlex 436 FWCI103.59230357

Somatic mutation rates scale with lifespan across mammals

article Full Text OpenAlex 422 FWCI56.28599757

Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis

review Full Text OpenAlex 420 FWCI51.68904635

Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer

article Full Text OpenAlex 390 FWCI57.35140763

Chemotherapy Side-Effects: Not All DNA Damage Is Equal

review Full Text OpenAlex 388 FWCI351.15254177

Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1

article Full Text OpenAlex 366 FWCI47.7508333

Hallmarks of DNA replication stress

review Full Text OpenAlex 361 FWCI43.19727445

Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids

review Full Text OpenAlex 346 FWCI43.9356894

NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

article Full Text OpenAlex 338 FWCI162.32356209