专题：DNA Repair Mechanisms

This cluster of papers focuses on the molecular mechanisms of the DNA damage response, including DNA repair pathways, genomic instability, the role of ATM and ATR kinases, homologous recombination, cell cycle checkpoints, and their implications in cancer biology. It also explores the involvement of histone H2AX and chromatin in maintaining genome stability.
最新文献
BCDX2–CX3 and DX2–CX3 complexes assemble and stabilize RAD51 filaments

article Full Text OpenAlex

RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity

article Full Text OpenAlex

Structures and enzymatic mechanisms of DRT7/UG10 antiphage reverse transcriptases

article Full Text OpenAlex

Transient telomere uncapping triggers telomeric and subtelomeric rearrangements

article Full Text OpenAlex

Multifunctional roles of Brl1-Brr6 in nuclear envelope fusion during nuclear pore complex biogenesis

article Full Text OpenAlex

Nucleotide salvage, genome instability, and potential therapeutic applications

article Full Text OpenAlex

Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability

article Full Text OpenAlex

RCC1 depletion drives protein transport defects and rupture in micronuclei

article Full Text OpenAlex

The PARG frontier: mechanisms of PAR turnover and opportunities in precision oncology

article Full Text OpenAlex

Cisplatin disrupts OCT1-DNMT1-piRNA epigenetic regulatory axis to suppress GAB2-mediated aggressiveness in OSCC

article Full Text OpenAlex

近5年高被引文献
Targeting DNA damage response pathways in cancer

review Full Text OpenAlex 794 FWCI75.0279

Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis

review Full Text OpenAlex 456 FWCI36.4533

Somatic mutation rates scale with lifespan across mammals

article Full Text OpenAlex 450 FWCI39.5871

NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

article Full Text OpenAlex 439 FWCI96.2618

Chemotherapy Side-Effects: Not All DNA Damage Is Equal

review Full Text OpenAlex 423 FWCI152.0251

Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1

article Full Text OpenAlex 410 FWCI33.9374

Hallmarks of DNA replication stress

review Full Text OpenAlex 409 FWCI30.5933

Metabolic regulation of homologous recombination repair by MRE11 lactylation

article Full Text OpenAlex 371 FWCI55.1136

Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids

review Full Text OpenAlex 370 FWCI31.073

Targeting replication stress in cancer therapy

review Full Text OpenAlex 341 FWCI26.26