专题：DNA Repair Mechanisms

This cluster of papers focuses on the molecular mechanisms of the DNA damage response, including DNA repair pathways, genomic instability, the role of ATM and ATR kinases, homologous recombination, cell cycle checkpoints, and their implications in cancer biology. It also explores the involvement of histone H2AX and chromatin in maintaining genome stability.
最新文献
Structural basis of RECQL5-induced RNA polymerase II transcription braking and subsequent reactivation

article Full Text OpenAlex

Structural insights into transcriptional regulation by the helicase RECQL5

article Full Text OpenAlex

The long-term effects of chemotherapy on normal blood cells

article Full Text OpenAlex

Targeting MTAP increases PARP inhibitor susceptibility in triple-negative breast cancer through a feed-forward loop

article Full Text OpenAlex

The PARP1–EXD2 axis orchestrates R-loop resolution to safeguard genome stability

article Full Text OpenAlex

The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells

article Full Text OpenAlex

Spatiotemporal orchestration of mitosis by cyclin-dependent kinase

article Full Text OpenAlex

CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance

article Full Text OpenAlex

Induction of a mismatch repair deficient genotype by tailored chemical mutagenesis in experimental models of cancer

article Full Text OpenAlex

Transcriptional repression facilitates RNA:DNA hybrid accumulation at DNA double-strand breaks

article Full Text OpenAlex

近5年高被引文献
Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer

article Full Text OpenAlex 1306 FWCI110.098

Cell cycle control in cancer

review Full Text OpenAlex 1095 FWCI30.955

The central role of DNA damage in the ageing process

review Full Text OpenAlex 715 FWCI16.923

DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy

review Full Text OpenAlex 596 FWCI13.204

Targeting DNA damage response pathways in cancer

review Full Text OpenAlex 536 FWCI22.373

Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation

article Full Text OpenAlex 408 FWCI27.086

Understanding and overcoming resistance to PARP inhibitors in cancer therapy

review Full Text OpenAlex 395 FWCI11.613

Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

article Full Text OpenAlex 386 FWCI33.79

Somatic mutation rates scale with lifespan across mammals

article Full Text OpenAlex 354 FWCI44.242

Talazoparib plus enzalutamide in men with first-line metastatic castration-resistant prostate cancer (TALAPRO-2): a randomised, placebo-controlled, phase 3 trial

article Full Text OpenAlex 354 FWCI81.145