专题：Protein Kinase Regulation and GTPase Signaling

This cluster of papers focuses on the molecular mechanisms of Ras signaling pathways, including the role of protein kinases, GTPases, and phospholipase C in cell regulation and cancer therapy. It explores the involvement of calcium signaling, cell migration, and transcriptional regulation in oncogenic mutations.
最新文献
Cancer interception with KRAS inhibitors in preclinical models of pancreatic ductal adenocarcinoma

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Local Ras/actin signaling orients individual pseudopods in shallow gradients

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PKMζ-PKCι/λ double-knockout demonstrates atypical PKC is crucial for the persistence of hippocampal LTP and spatial memory

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Lipid Pocket Binders Impose Allosteric Changes of Protein Dynamics Around the Active Site of the Protein Kinase p38α

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Activation of GPR97/ADGRG3 by its tethered agonist, but not by beclomethasone, induces neutrophil polarization and migration

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ADT-030, a novel PDE10 inhibitor, demonstrates potent antitumor activity in pancreatic ductal adenocarcinoma

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Coupling of death receptor p75 NTR to the RhoA and NF-kB pathways differentially regulates internalization in hippocampal and cerebellar neurons

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Distinct impact of PI(4)P flux on PI(4,5)P 2 steady states and oscillations

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Inhibitory probes for spatiotemporal analysis of Gαs protein signaling

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Covalent inhibitor design confers activity against both GDP- and GTP-bound forms of KRAS G12C

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近5年高被引文献
Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRAS G12C Mutation

article Full Text OpenAlex 900 FWCI73.6678

Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

review Full Text OpenAlex 750 FWCI117.694

An atlas of substrate specificities for the human serine/threonine kinome

article Full Text OpenAlex 644 FWCI96.924

Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

article Full Text OpenAlex 472 FWCI37.6582

Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

article Full Text OpenAlex 454 FWCI71.3664

Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial

article Full Text OpenAlex 347 FWCI27.9397

Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy

article Full Text OpenAlex 294 FWCI71.3375

Expanding the Reach of Precision Oncology by Drugging All KRAS Mutants

article Full Text OpenAlex 293 FWCI23.791

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

article Full Text OpenAlex 277 FWCI66.731

Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation

article Full Text OpenAlex 266 FWCI41.4739