专题：Protein Kinase Regulation and GTPase Signaling

This cluster of papers focuses on the molecular mechanisms of Ras signaling pathways, including the role of protein kinases, GTPases, and phospholipase C in cell regulation and cancer therapy. It explores the involvement of calcium signaling, cell migration, and transcriptional regulation in oncogenic mutations.
最新文献
Utilizing a combined approach of machine learning and structure-based drug design principles to identify potential hits targeting SphK1

article Full Text OpenAlex

Kinase signaling cascades: An updated mechanistic landscape

review Full Text OpenAlex

Optimized conditions for GTP loading of Ras

preprint Full Text OpenAlex

Charting the future of AL amyloidosis: Diagnostic advancements, prognostic insights, and therapeutic challenges

review Full Text OpenAlex

Regarding: Standard and advanced echocardiographic study of patients with Paget's disease of bone: Evidence of a Pagetic heart disease?

letter Full Text OpenAlex

Impact of Vutrisiran on Cardiac Biomarkers in Patients With Transthyretin Amyloidosis With Cardiomyopathy From HELIOS-B

article Full Text OpenAlex

Proteomic analyses identify targets, pathways, and cellular consequences of oncogenic KRAS signaling

article Full Text OpenAlex

Introducing a revised version of the Kumamoto scale as an easy-to-use clinical tool for monitoring multisystemic changes in hereditary transthyretin amyloidosis

article Full Text OpenAlex

Molecular requirements for PLK1 activation by T-loop phosphorylation

preprint Full Text OpenAlex

Druggability of Phospholipase C-β Isoforms with Small Peptides Patterned after the Autoinhibitory XY Linker

preprint Full Text OpenAlex

近5年高被引文献
Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRAS G12C Mutation

article Full Text OpenAlex 684 FWCI64.172

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor

article Full Text OpenAlex 526 FWCI30.741

Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

review Full Text OpenAlex 481 FWCI24.984

Acquired Resistance to KRASG12C Inhibition in Cancer

article Full Text OpenAlex 474 FWCI55.646

An atlas of substrate specificities for the human serine/threonine kinome

article Full Text OpenAlex 460 FWCI78.651

Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

article Full Text OpenAlex 352 FWCI33.072

Diverse alterations associated with resistance to KRAS(G12C) inhibition

article Full Text OpenAlex 345 FWCI23.037

Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

article Full Text OpenAlex 339 FWCI49.381

Protein kinase CK2: a potential therapeutic target for diverse human diseases

review Full Text OpenAlex 288 FWCI6.734

Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial

article Full Text OpenAlex 268 FWCI25.086