专题：Protein Kinase Regulation and GTPase Signaling

This cluster of papers focuses on the molecular mechanisms of Ras signaling pathways, including the role of protein kinases, GTPases, and phospholipase C in cell regulation and cancer therapy. It explores the involvement of calcium signaling, cell migration, and transcriptional regulation in oncogenic mutations.
最新文献
METTL3-mediated m

article Full Text OpenAlex

Synthesis and mechanistic investigation of short peptides as aβ aggregation inhibitors

article Full Text OpenAlex

The Rho/MRTF-pirin axis: a promising target for overcoming melanoma drug resistance

article Full Text OpenAlex

Description of peripheral nervous system involvement in wild-type transthyretin amyloidosis: A clinical and electrophysiological study

article Full Text OpenAlex

SH2scan: Mapping SH2 domain-ligand binding selectivity for inhibitors and degraders

preprint Full Text OpenAlex

Front-biased activation of Ras-Rab5-Rac1 loop coordinates collective cell migration

article Full Text OpenAlex

Energy stress-induced PKCζ S-glutathionylation is essential for LKB1 cytoplasmic translocation and AMPK activation

article Full Text OpenAlex

The Nitrergic Mechanism of Geraniol in PTZ-Induced Seizures

article Full Text OpenAlex

PACS2 initiates foam cell formation in macrophages through the ROS-PPARγ-CD36 positive feedback loop

article Full Text OpenAlex

Role of extracellular space and matrix remodeling in cardiac amyloidosis

review Full Text OpenAlex

近5年高被引文献
Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRAS G12C Mutation

article Full Text OpenAlex 617 FWCI63.852

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor

article Full Text OpenAlex 485 FWCI30.729

Acquired Resistance to KRASG12C Inhibition in Cancer

article Full Text OpenAlex 459 FWCI55.661

An atlas of substrate specificities for the human serine/threonine kinome

article Full Text OpenAlex 422 FWCI79.233

Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

review Full Text OpenAlex 395 FWCI22.505

Diverse alterations associated with resistance to KRAS(G12C) inhibition

article Full Text OpenAlex 325 FWCI22.949

Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

article Full Text OpenAlex 318 FWCI31.874

Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

article Full Text OpenAlex 296 FWCI48.764

Protein kinase CK2: a potential therapeutic target for diverse human diseases

review Full Text OpenAlex 274 FWCI6.737

Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial

article Full Text OpenAlex 247 FWCI24.724