专题：Protein Kinase Regulation and GTPase Signaling

This cluster of papers focuses on the molecular mechanisms of Ras signaling pathways, including the role of protein kinases, GTPases, and phospholipase C in cell regulation and cancer therapy. It explores the involvement of calcium signaling, cell migration, and transcriptional regulation in oncogenic mutations.
最新文献
Janus kinase inhibitor exposure and acute coronary event patterns in rheumatoid arthritis: a treatment-aware retrospective study

article Full Text OpenAlex

Precision Medicine in Pancreatic Cancer: Targeting KRAS and Beyond

article Full Text OpenAlex

KRAS G12C–Targeted Therapy in Non-Small Cell Lung Cancer: From Resistant Salvage to Potential First-Line Backbone

article Full Text OpenAlex

KRAS-G12D inhibitor HRS-4642 plus chemotherapy in advanced KRASG12D-mutant pancreatic cancer: a phase 1b/2 trial

article Full Text OpenAlex

Allosteric Inhibition of PKMYT1 Induces a Unique, Inactive ATP Binding Site Conformation

article Full Text OpenAlex

KRAS G12R in pancreatic cancer: why this mutation resists current inhibitor strategies

article Full Text OpenAlex

Investigating the P450-Mediated Cross-Linking of the Atypical GPA Complestatin Using Alternate Peptide Probes

article Full Text OpenAlex

Targeted KRASG12V Degradation In Vivo Elicits Lung Adenocarcinoma Regression with Subsequent Relapse from Dysregulated Proteolysis

article Full Text OpenAlex

Research Progress on the Relationship between Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) and Obesity Complicated with Type 2 Diabetes Mellitus

article Full Text OpenAlex

Covalent Chemical Tagging of Transmembrane Transport Proteins Illuminates the Internalization Pathways of Xenosiderophores

article Full Text OpenAlex

近5年高被引文献
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

article Full Text OpenAlex 933 FWCI86.8928

An atlas of substrate specificities for the human serine/threonine kinome

article Full Text OpenAlex 746 FWCI82.1481

Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

article Full Text OpenAlex 542 FWCI35.1191

Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

article Full Text OpenAlex 533 FWCI48.6716

Adagrasib with or without Cetuximab in Colorectal Cancer with Mutated KRAS G12C

article Full Text OpenAlex 516 FWCI39.3231

Sotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated KRAS G12C

article Full Text OpenAlex 370 FWCI41.7258

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

article Full Text OpenAlex 353 FWCI54.9164

Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers

article Full Text OpenAlex 323 FWCI49.558

Expanding the Reach of Precision Oncology by Drugging All KRAS Mutants

article Full Text OpenAlex 323 FWCI21.7122

Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation

article Full Text OpenAlex 312 FWCI28.2932