专题：Protein Kinase Regulation and GTPase Signaling

This cluster of papers focuses on the molecular mechanisms of Ras signaling pathways, including the role of protein kinases, GTPases, and phospholipase C in cell regulation and cancer therapy. It explores the involvement of calcium signaling, cell migration, and transcriptional regulation in oncogenic mutations.
最新文献
Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH

article Full Text OpenAlex

Hepatic GPR110 contributes to sex disparity in the development of MASH through oestrogen receptor α-dependent signalling

article Full Text OpenAlex

Constitutive Activity among Orphan GPCRs: Molecular Mechanisms and Pharmacological Perspectives

article Full Text OpenAlex

The molecular mechanism of cuproptosis and research progress in pancreatic diseases

article Full Text OpenAlex

The multifaceted phosphatidylinositol 5 phosphate 4-kinase proteins: molecular properties and biological functions

article Full Text OpenAlex

Progression of QRS duration – a potential surrogate marker of survival in ATTRwt amyloidosis patients

article Full Text OpenAlex

Dual inhibition of BRAF for cancer treatment: advances and therapeutic potential

review Full Text OpenAlex

Exploiting the Cryptic αD Pocket of Casein Kinase 2α (CK2α) to Deliver Highly Potent and Selective Type 1 Inhibitors

article Full Text OpenAlex

Substrate Stiffness Regulates the Osteogenesis of PDLSCs Via ERK-Mediated YAP Nuclear Translocation

article Full Text OpenAlex

Impact of Vutrisiran on Outpatient Worsening Heart Failure in Patients with Transthyretin Amyloidosis with Cardiomyopathy in the HELIOS-B Trial

article Full Text OpenAlex

近5年高被引文献
Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRAS G12C Mutation

article Full Text OpenAlex 850 FWCI104.11650765

Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

review Full Text OpenAlex 675 FWCI125.69886597

An atlas of substrate specificities for the human serine/threonine kinome

article Full Text OpenAlex 591 FWCI121.62837949

Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

article Full Text OpenAlex 437 FWCI52.67359962

Pan-KRAS inhibitor disables oncogenic signalling and tumour growth

article Full Text OpenAlex 425 FWCI79.28126406

Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial

article Full Text OpenAlex 328 FWCI39.62826887

Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy

article Full Text OpenAlex 260 FWCI124.86427853

Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy

article Full Text OpenAlex 249 FWCI119.10131183

Single-Agent Divarasib (GDC-6036) in Solid Tumors with a KRAS G12C Mutation

article Full Text OpenAlex 244 FWCI45.11790905

Intrinsically disordered proteins play diverse roles in cell signaling

review Full Text OpenAlex 188 FWCI22.52165591