专题:Genomics and Chromatin Dynamics

This cluster of papers focuses on the regulation of chromatin structure and function, including topics such as histone modifications, transcriptional regulation, enhancers, DNA elements, 3D genome organization, and nucleosome positioning. The research covers a wide range of molecular mechanisms involved in controlling gene expression and epigenetic processes.
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Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types

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TxPert: using multiple knowledge graphs for prediction of transcriptomic perturbation effects

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De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion

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Multiomics and deep learning dissect regulatory syntax in human development

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3d-OT: a deep geometry-aware framework for heterogeneous slices alignment of spatial multi-omics

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DNA methylation site loss for plasticity-led novel trait genetic fixation

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Unstructured transcription factor interactions enable emergent specificity

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Nucleosome spacing across cell types, diseases, and ages

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Cell-free chromatin state tracing reveals disease origin and therapy responses

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Genetically encoded assembly recorder temporally resolves cellular history

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