This cluster of papers focuses on the systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS), covering topics such as classification criteria, autoantibody development, interferon-inducible genes, nephritis, B lymphocyte depletion therapy, thrombosis risk, immunopathogenesis, toll-like receptors, and the epidemiology of autoimmune diseases. The research aims to improve understanding, diagnosis, classification, and management of SLE and APS.