专题：Pharmacogenetics and Drug Metabolism

This cluster of papers focuses on the study of drug metabolism, particularly the role of Cytochrome P450 enzymes, genetic variations impacting enzyme activities, pharmacogenetics, personalized medicine, and the influence of polymorphisms on drug response and pharmacokinetics. It also explores the impact of these factors on warfarin dose estimation and xenobiotic metabolism.
最新文献
Leveraging PCORnet® to Advance Clinical Genetics and the Genomic Learning Health System

article Full Text OpenAlex

How PCORnet® Could Advance Postmarket Evidence Generation

article Full Text OpenAlex

Dietetic guidance for nutritional management of people with phenylketonuria receiving sepiapterin

article Full Text OpenAlex

Pharmacoinformatics in Drug–Excipient Interactions

article Full Text OpenAlex

Novel emerging cell and organoid systems for the study of drug metabolism and toxicity in humans

review Full Text OpenAlex

Allosteric solution to the problems of undruggable targets, drug toxicity, and emerging resistance

review Full Text OpenAlex

Relationship of the 1846G > A Polymorphism of the CYP2D6 Gene to the Equilibrium Concentration Levels of Haloperidol in Patients with Acute Alcoholic Hallucinosis

article Full Text OpenAlex

Biological sex differences in pharmacokinetics and adverse drug reactions

review Full Text OpenAlex

Cytochrome P450 Cyp2s1 regulation of the intestinal metabolome and microbiome

article Full Text OpenAlex

Performance of the Egoo test for phenylalanine measurement in females with phenylketonuria

article Full Text OpenAlex

近5年高被引文献
Why 90% of clinical drug development fails and how to improve it?

review Full Text OpenAlex 1323 FWCI555.19630366

An Introduction to Medicinal Chemistry

book Full Text OpenAlex 744 FWCI40.6797385

ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support

article Full Text OpenAlex 632 FWCI499.36568311

TTD: Therapeutic Target Database describing target druggability information

article Full Text OpenAlex 464 FWCI148.3013778

A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study

article Full Text OpenAlex 454 FWCI160.66232047

Deuterium in drug discovery: progress, opportunities and challenges

review Full Text OpenAlex 401 FWCI73.48828926

Rings in Clinical Trials and Drugs: Present and Future

review Full Text OpenAlex 365 FWCI95.5952382

Molecular modeling in drug discovery

article Full Text OpenAlex 321 FWCI83.74458883

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants

article Full Text OpenAlex 306 FWCI105.71719789

Drug Design by Pharmacophore and Virtual Screening Approach

review Full Text OpenAlex 305 FWCI79.00432909