专题：Pharmacogenetics and Drug Metabolism

This cluster of papers focuses on the study of drug metabolism, particularly the role of Cytochrome P450 enzymes, genetic variations impacting enzyme activities, pharmacogenetics, personalized medicine, and the influence of polymorphisms on drug response and pharmacokinetics. It also explores the impact of these factors on warfarin dose estimation and xenobiotic metabolism.
最新文献
Variational wavefunctions and energies for three spin states of Cytochrome P450 Compound I, CAS(25,23)

article Full Text OpenAlex

Computational Design of CYP102A1 Variants for Biosynthesis of a Next-Generation Antiplatelet Drug DT-678

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How Can Pharmacology Help Us Overcome the Challenges of Drug Repositioning as Antivirals to Treat Emerging Pathogens? The Example of Covid‐19

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Predicting mycophenolic acid exposure in paediatric lupus nephritis: a real-world study across three clinical scenarios

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Plant-drug Interactions: Mechanisms and Clinical Implications of Cytochrome P450 Modulation by Common Phytochemicals

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From Population-Based PBPK to Individualized Virtual Twins: Clinical Validation and Applications in Medicine

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PKRxiv: A Best Practice Model for Advancing Pharmacoequity Through Open Pharmacokinetic Data Sharing

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A review of pharmacogenomics in the individualization of pharmacological treatment: present and future

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Pharmacogenomics in the prediction of adverse effects of cardiovascular drugs: the PGx-CardioDrug project

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Linking interpersonal differences in gut microbiota composition and drug biotransformation activity

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近5年高被引文献
Why 90% of clinical drug development fails and how to improve it?

review Full Text OpenAlex 1514 FWCI330.39

ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support

article Full Text OpenAlex 874 FWCI298.597

An Introduction to Medicinal Chemistry

book Full Text OpenAlex 748 FWCI21.7748

TTD: Therapeutic Target Database describing target druggability information

article Full Text OpenAlex 562 FWCI111.4737

A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study

article Full Text OpenAlex 492 FWCI122.7227

Deuterium in drug discovery: progress, opportunities and challenges

review Full Text OpenAlex 457 FWCI49.1556

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update

article Full Text OpenAlex 442 FWCI66.9148

Rings in Clinical Trials and Drugs: Present and Future

review Full Text OpenAlex 409 FWCI55.4623

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants

article Full Text OpenAlex 374 FWCI91.3057

Molecular modeling in drug discovery

article Full Text OpenAlex 353 FWCI48.7581