专题：Pharmacogenetics and Drug Metabolism

This cluster of papers focuses on the study of drug metabolism, particularly the role of Cytochrome P450 enzymes, genetic variations impacting enzyme activities, pharmacogenetics, personalized medicine, and the influence of polymorphisms on drug response and pharmacokinetics. It also explores the impact of these factors on warfarin dose estimation and xenobiotic metabolism.
最新文献
Decentralized clinical trials in cardiovascular disease : A primer for clinical trialists

article Full Text OpenAlex

Mutagenicity of N -nitroso-fluoxetine and N -nitroso-varenicline in human HepaRG cell models

article Full Text OpenAlex

Sex-specific differences in liver DNA methylation patterns and epigenetic aging in mice

article Full Text OpenAlex

Letter to the Editor: Commending the Feasibility of CYP2C19 Pharmacogenetic Testing in Personalized Antiplatelet Therapy—Insights and Perspectives

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The role of CYP3A-CYP2E1 interactions in activation of CYP3A enzymes by chronic alcohol exposure

article Full Text OpenAlex

Age and Gender Heterogeneity in Adverse Drug Reactions Associated with Hemp Use: Evidence from the FDA Pharmacovigilance Data in the Last Two Decades

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Plant-drug Interactions: Mechanisms and Clinical Implications of Cytochrome P450 Modulation by Common Phytochemicals

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Intoxicación sistémica; desde la perspectiva causa – efecto. “todo lo que entra, tiene que salir, si no sale se acumula y te intoxica”

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PKRxiv: A Best Practice Model for Advancing Pharmacoequity Through Open Pharmacokinetic Data Sharing

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Pragmatic trial design enhances diversity and retention among research participants with Lewy body diseases

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近5年高被引文献
Why 90% of clinical drug development fails and how to improve it?

review Full Text OpenAlex 1438 FWCI331.0018

ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support

article Full Text OpenAlex 772 FWCI286.3276

An Introduction to Medicinal Chemistry

book Full Text OpenAlex 746 FWCI22.066

TTD: Therapeutic Target Database describing target druggability information

article Full Text OpenAlex 512 FWCI106.0396

A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study

article Full Text OpenAlex 468 FWCI119.1311

Deuterium in drug discovery: progress, opportunities and challenges

review Full Text OpenAlex 431 FWCI49.3418

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update

article Full Text OpenAlex 424 FWCI65.3363

Rings in Clinical Trials and Drugs: Present and Future

review Full Text OpenAlex 391 FWCI54.7073

Molecular modeling in drug discovery

article Full Text OpenAlex 343 FWCI48.0944

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants

article Full Text OpenAlex 335 FWCI83.0848