专题：Pharmacogenetics and Drug Metabolism

This cluster of papers focuses on the study of drug metabolism, particularly the role of Cytochrome P450 enzymes, genetic variations impacting enzyme activities, pharmacogenetics, personalized medicine, and the influence of polymorphisms on drug response and pharmacokinetics. It also explores the impact of these factors on warfarin dose estimation and xenobiotic metabolism.
最新文献
近5年高被引文献
Why 90% of clinical drug development fails and how to improve it?

article Full Text OpenAlex 1682 FWCI295.2957

ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support

article Full Text OpenAlex 1104 FWCI269.416

An Introduction to Medicinal Chemistry

book Full Text OpenAlex 755 FWCI23.5863

TTD: Therapeutic Target Database describing target druggability information

article Full Text OpenAlex 627 FWCI89.5726

A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study

article Full Text OpenAlex 532 FWCI108.3321

Deuterium in drug discovery: progress, opportunities and challenges

article Full Text OpenAlex 510 FWCI43.412

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update

article Full Text OpenAlex 483 FWCI60.9531

Rings in Clinical Trials and Drugs: Present and Future

article Full Text OpenAlex 454 FWCI48.1162

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants

article Full Text OpenAlex 425 FWCI84.8601

Drug Design by Pharmacophore and Virtual Screening Approach

article Full Text OpenAlex 380 FWCI39.6562