专题：Pharmacogenetics and Drug Metabolism

This cluster of papers focuses on the study of drug metabolism, particularly the role of Cytochrome P450 enzymes, genetic variations impacting enzyme activities, pharmacogenetics, personalized medicine, and the influence of polymorphisms on drug response and pharmacokinetics. It also explores the impact of these factors on warfarin dose estimation and xenobiotic metabolism.
最新文献
Synthesis and In Vitro Metabolic Profiling of the Selective Androgen Receptor Modulator (SARM) LY305

article Full Text OpenAlex

Editorial: Cephalosporin‐Induced Liver Injury—Interesting but Tricky

editorial Full Text OpenAlex

Model‐Informed Paradigm in Drug Development—An End‐To‐End Case Study From Upadacitinib Development

review Full Text OpenAlex

Diisopromine as a non-labelled CYP3A4 substrate: Implications for breath test development

review Full Text OpenAlex

Using of transporter proteins to improve the uptake efficiency of hydrophobic compounds by Escherichia coli: a coordinated synthesis of START protein and P450scc system proteins to enhance cholesterol biotransformation

article Full Text OpenAlex

Clinical and Genetic Associations in Cephalosporin‐Induced Liver Injury: Insights From the Drug‐Induced Liver Injury Network

article Full Text OpenAlex

Drug Interaction PBPK Modeling: Review of the Literature Exposes the Need for Increased Verification of Model Inputs and Outputs as Part of Credibility Assessment

review Full Text OpenAlex

Regulating the N-oxidation selectivity of P450BM3 monooxygenases for N-heterocycles through computer-assisted structure-guided design

article Full Text OpenAlex

Stability of Drugs and Dosage Forms

book-chapter Full Text OpenAlex

Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation

article Full Text OpenAlex

近5年高被引文献
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties

article Full Text OpenAlex 1937 FWCI199.397

Why 90% of clinical drug development fails and how to improve it?

review Full Text OpenAlex 1013 FWCI65.767

An Introduction to Medicinal Chemistry

book Full Text OpenAlex 764 FWCI21.242

Cytochrome P450 Enzymes and Drug Metabolism in Humans

review Full Text OpenAlex 669 FWCI22.105

An Evidence‐Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine

article Full Text OpenAlex 577 FWCI81.051

U.S. FDA Approved Drugs from 2015–June 2020: A Perspective

review Full Text OpenAlex 556 FWCI10.927

Current trends in computer aided drug design and a highlight of drugs discovered via computational techniques: A review

review Full Text OpenAlex 495 FWCI9.603

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

article Full Text OpenAlex 468 FWCI79.81

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

article Full Text OpenAlex 455 FWCI30.199

A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study

article Full Text OpenAlex 377 FWCI118.12