专题:Pharmacogenetics and Drug Metabolism

This cluster of papers focuses on the study of drug metabolism, particularly the role of Cytochrome P450 enzymes, genetic variations impacting enzyme activities, pharmacogenetics, personalized medicine, and the influence of polymorphisms on drug response and pharmacokinetics. It also explores the impact of these factors on warfarin dose estimation and xenobiotic metabolism.
最新文献
ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support

article Full Text OpenAlex

A skeletally diverse library of bioactive natural-product-like compounds enabled by late-stage P450-catalyzed oxyfunctionalization

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Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities

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Application of transporter assays for drug discovery and development: an update of the literature

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Cardiovascular Pharmacogenetics: From Discovery of Genetic Association to Clinical Adoption of Derived Test

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Highly Efficient Enzymatic Synthesis of C6-Substituted Δ1-3-Ketosteroids Enabled by Finely Tuning the Substrate Binding of 3-Ketosteroid-Δ1-Dehydrogenase

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Biotransformation of selected secondary metabolites by Alternaria species and the pharmaceutical, food and agricultural application of biotransformation products

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Meta-analysis of genome-wide association studies of stable warfarin dose in patients of African ancestry

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Simultaneously Predicting Pharmacokinetics of Loratadine and Desloratadine in Children Using a Whole‐Body Physiologically Based Pharmacokinetic Model

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Rifampicin and its derivatives: stability, disposition, and affinity towards pregnane X receptor employing 2D and 3D primary human hepatocytes

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近5年高被引文献
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties

article Full Text OpenAlex 2283 FWCI260.62997107

Why 90% of clinical drug development fails and how to improve it?

review Full Text OpenAlex 1253 FWCI531.40217636

Cytochrome P450 Enzymes and Drug Metabolism in Humans

review Full Text OpenAlex 793 FWCI94.57892179

An Introduction to Medicinal Chemistry

book Full Text OpenAlex 743 FWCI40.17124177

An Evidence‐Based Framework for Evaluating Pharmacogenomics Knowledge for Personalized Medicine

article Full Text OpenAlex 671 FWCI94.38064313

U.S. FDA Approved Drugs from 2015–June 2020: A Perspective

review Full Text OpenAlex 654 FWCI75.8836648

Current trends in computer aided drug design and a highlight of drugs discovered via computational techniques: A review

review Full Text OpenAlex 556 FWCI68.19924304

ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support

article Full Text OpenAlex 553 FWCI436.94497272

Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

article Full Text OpenAlex 539 FWCI42.32907343

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors

article Full Text OpenAlex 478 FWCI89.02711925