Pharmacogenetics and Drug Metabolism -- 专题文献

专题：Pharmacogenetics and Drug Metabolism

This cluster of papers focuses on the study of drug metabolism, particularly the role of Cytochrome P450 enzymes, genetic variations impacting enzyme activities, pharmacogenetics, personalized medicine, and the influence of polymorphisms on drug response and pharmacokinetics. It also explores the impact of these factors on warfarin dose estimation and xenobiotic metabolism.

近5年高被引文献

Why 90% of clinical drug development fails and how to improve it?

review Full Text OpenAlex 1588 FWCI330.6716

ADMETlab 3.0: an updated comprehensive online ADMET prediction platform enhanced with broader coverage, improved performance, API functionality and decision support

article Full Text OpenAlex 970 FWCI304.9821

An Introduction to Medicinal Chemistry

book Full Text OpenAlex 752 FWCI22.2538

**TTD: Therapeutic Target Database describing target druggability information**

article Full Text OpenAlex 582 FWCI110.2194

A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study

article Full Text OpenAlex 511 FWCI121.4993

Deuterium in drug discovery: progress, opportunities and challenges

review Full Text OpenAlex 477 FWCI48.6944

**Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update**

article Full Text OpenAlex 455 FWCI66.8838

Rings in Clinical Trials and Drugs: Present and Future

review Full Text OpenAlex 428 FWCI55.3991

**Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants**

article Full Text OpenAlex 401 FWCI93.407

Drug Design by Pharmacophore and Virtual Screening Approach

review Full Text OpenAlex 361 FWCI45.6639