专题:RNA and protein synthesis mechanisms

This cluster of papers focuses on the structure of ribosomes, mechanisms of translation, RNA secondary structure prediction, genetic code expansion, codon usage, tRNA dynamics, and riboswitches. It explores the molecular mechanisms underlying protein synthesis and the role of RNA in regulating translation. The research also delves into the impact of ribosome structure on cellular processes and the potential applications in synthetic biology.
最新文献
Rapid directed evolution guided by protein language models and epistatic interactions

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Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

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A small polymerase ribozyme that can synthesize itself and its complementary strand

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2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity

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Using a GPT-5-driven autonomous lab to optimize the cost and titer of cell-free protein synthesis

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Construction of complex and diverse DNA sequences using DNA three-way junctions

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A genetically encoded device for transcriptome storage in mammalian cells

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Predicting small molecule–RNA interactions without RNA tertiary structures

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Chronic stress antagonizes formation of stress granules

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Suboptimal codon pairs trigger ribosome collisions and cellular quality control responses in tRNA modification mutants

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近5年高被引文献
Evolutionary-scale prediction of atomic-level protein structure with a language model

article Full Text OpenAlex 4622 FWCI682.613

TBtools-II: A “one for all, all for one” bioinformatics platform for biological big-data mining

article Full Text OpenAlex 3265 FWCI509.1198

Fast and accurate protein structure search with Foldseek

article Full Text OpenAlex 2243 FWCI327.3651

SignalP 6.0 predicts all five types of signal peptides using protein language models

article Full Text OpenAlex 2093 FWCI179.4489

KEGG: biological systems database as a model of the real world

article Full Text OpenAlex 1969 FWCI427.0569

AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences

article Full Text OpenAlex 1820 FWCI167.3667

De novo design of protein structure and function with RFdiffusion

article Full Text OpenAlex 1810 FWCI266.8785

Robust deep learning–based protein sequence design using ProteinMPNN

article Full Text OpenAlex 1718 FWCI124.003

DeepTMHMM predicts alpha and beta transmembrane proteins using deep neural networks

preprint Full Text OpenAlex 1440 FWCI0

The diversity of splicing modifiers acting on A -1 bulged 5 -splice sites reveals rules for rational drug design

article Full Text OpenAlex 1192 FWCI32.9673