专题：Cancer-related Molecular Pathways

This cluster of papers focuses on the p53 signaling network, exploring its role in cell cycle regulation, tumor suppression, cancer therapy, apoptosis, and the impact of mutations. The papers cover various aspects of p53-MDM2 interaction, cyclin-dependent kinases, and the intricate mechanisms of p53 regulation in the context of cancer research.
最新文献
Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis

article Full Text OpenAlex

Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia

article Full Text OpenAlex

Targeting MDM2-mediated suppression of p53 with idasanutlin: a promising therapeutic approach for acute lymphoblastic leukemia

article Full Text OpenAlex

DEK::AFF2 Fusion-Associated Squamous Cell Carcinoma: A Case Series with Literature Review on an Emerging and Challenging Entity

review Full Text OpenAlex

Assessing Darkness of the Human Kinome from a Medicinal Chemistry Perspective

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Effects of Vitamin D on tumor cell proliferation and migration, tumor initiation and anti-tumor immune response in head and neck squamous cell carcinomas

article Full Text OpenAlex

Combination screen in multi-cell type tumor spheroids reveals interaction between aryl hydrocarbon receptor antagonists and E1 ubiquitin-activating enzyme inhibitor

article Full Text OpenAlex

Combination kinase inhibitors and immunotherapy for unresectable anaplastic thyroid carcinoma: A retrospective single-center study

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Disparities in receipt of 1-st line CDK4/6 inhibitors with endocrine therapy for treatment of hormone receptor positive, HER2 negative metastatic breast cancer in the real-world setting

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Predictors of response to CDK4/6i retrial after prior CDK4/6i failure in ER+ metastatic breast cancer

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近5年高被引文献
Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer

article Full Text OpenAlex 1673 FWCI164.5288604

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

review Full Text OpenAlex 1438 FWCI111.96003515

Targeting PI3K/Akt signal transduction for cancer therapy

review Full Text OpenAlex 1437 FWCI76.27035811

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

review Full Text OpenAlex 1370 FWCI160.70755928

Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

review Full Text OpenAlex 1331 FWCI199.3147621

Cell cycle control in cancer

review Full Text OpenAlex 1289 FWCI98.85609845

Cell cycle regulation: p53-p21-RB signaling

review Full Text OpenAlex 1069 FWCI165.94667039

Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology

article Full Text OpenAlex 1045 FWCI163.44617448

BindingDB Entry 50022536: Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.

article Full Text OpenAlex 844 FWCI0

The MYC oncogene — the grand orchestrator of cancer growth and immune evasion

review Full Text OpenAlex 813 FWCI54.42309441