专题：Cancer-related Molecular Pathways

This cluster of papers focuses on the p53 signaling network, exploring its role in cell cycle regulation, tumor suppression, cancer therapy, apoptosis, and the impact of mutations. The papers cover various aspects of p53-MDM2 interaction, cyclin-dependent kinases, and the intricate mechanisms of p53 regulation in the context of cancer research.
最新文献
Reirradiation After Incomplete Salvage in p16-Positive Oropharyngeal Carcinoma: How Far Should We Go?

article Full Text OpenAlex

Single-cell profiling reveals reprogrammed hierarchy and disrupted immune-stromal ecosystem in TP53-mutated AML

article Full Text OpenAlex

Microtubule depolymerization at kinetochores restricts anaphase spindle elongation

article Full Text OpenAlex

Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry

article Full Text OpenAlex

Lenacapavir treatment–emergent HIV-1 capsid resistance mutations are frequently associated with replication defects

article Full Text OpenAlex

Phase II Trial of Ribociclib Plus Letrozole in Women With Recurrent Low-Grade Serous Carcinoma of the Ovary, Fallopian Tube, or Peritoneum: A GOG Partners Trial (GOG 3026)

article Full Text OpenAlex

Imlunestrant with or without abemaciclib in advanced breast cancer: updated efficacy results from the phase III EMBER-3 trial

article Full Text OpenAlex

CDK4/6 inhibition mitigates chemotherapy-induced expansion of TP53-mutant clonal hematopoiesis

article Full Text OpenAlex

cdk2 is essential for synapsis completion and gametogenesis in zebrafish

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CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen

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近5年高被引文献
Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics

review Full Text OpenAlex 1509 FWCI146.0768

Cell cycle regulation: p53-p21-RB signaling

review Full Text OpenAlex 1169 FWCI120.8587

BindingDB Entry 50022536: Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.

article Full Text OpenAlex 844 FWCI0

Recent advances in therapeutic strategies for triple-negative breast cancer

review Full Text OpenAlex 830 FWCI80.5724

Targeting p53 pathways: mechanisms, structures and advances in therapy

review Full Text OpenAlex 804 FWCI187.1184

Targeting DNA damage response pathways in cancer

review Full Text OpenAlex 772 FWCI75.3405

Drugging p53 in cancer: one protein, many targets

review Full Text OpenAlex 678 FWCI67.9278

Overall Survival with Ribociclib plus Letrozole in Advanced Breast Cancer

article Full Text OpenAlex 656 FWCI94.0814

Capivasertib in Hormone Receptor–Positive Advanced Breast Cancer

article Full Text OpenAlex 615 FWCI161.8292

Hypoxia-inducible factors: cancer progression and clinical translation

review Full Text OpenAlex 516 FWCI47.1801