专题：RNA Research and Splicing

This cluster of papers focuses on the regulation of RNA processing and function, including topics such as alternative splicing, RNA-binding proteins, phase separation, mRNA decay, stress granules, transcriptome analysis, exon junctions, polyadenylation, nonsense-mediated decay, and RNA phase transitions.
最新文献
LUMI-lab: A foundation model-driven autonomous platform enabling discovery of ionizable lipid designs for mRNA delivery

article Full Text OpenAlex

Nuclear speckles enable processing of RNA from GC-rich isochores

article Full Text OpenAlex

Subcellular localization as a driver of protein function

article Full Text OpenAlex

Decoupling phase separation and fibrillization preserves activity of biomolecular condensates

article Full Text OpenAlex

MYC binding to nascent RNA suppresses innate immune signaling by R-loop-derived RNA-DNA hybrids

article Full Text OpenAlex

A genetically encoded device for transcriptome storage in mammalian cells

article Full Text OpenAlex

De novo and inherited dominant variants in U4 and U6 snRNA genes cause retinitis pigmentosa

article Full Text OpenAlex

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains

article Full Text OpenAlex

Viscoelasticity and interface properties of multi-component condensates govern protein sequestration and suppression of amyloid formation

article Full Text OpenAlex

PARPs and PARP inhibitors: molecular mechanisms and clinical applications

article Full Text OpenAlex

近5年高被引文献
YaHS: yet another Hi-C scaffolding tool

article Full Text OpenAlex 2170 FWCI163.1092

Long non-coding RNAs: definitions, functions, challenges and recommendations

review Full Text OpenAlex 2151 FWCI507.1213

The diversity of splicing modifiers acting on A -1 bulged 5 -splice sites reveals rules for rational drug design

article Full Text OpenAlex 1192 FWCI33.0217

Histone post-translational modifications — cause and consequence of genome function

review Full Text OpenAlex 1043 FWCI85.1947

Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

article Full Text OpenAlex 807 FWCI91.0262

Integrated lncRNA function upon genomic and epigenomic regulation

review Full Text OpenAlex 724 FWCI62.9991

A conceptual framework for understanding phase separation and addressing open questions and challenges

review Full Text OpenAlex 687 FWCI55.4675

SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks

article Full Text OpenAlex 637 FWCI93.9862

The molecular basis for cellular function of intrinsically disordered protein regions

review Full Text OpenAlex 631 FWCI92.9517

RNA-based therapeutics: an overview and prospectus

review Full Text OpenAlex 580 FWCI45.8474