专题：Protease and Inhibitor Mechanisms

This cluster of papers explores the multifaceted roles of matrix metalloproteinases (MMPs) in cancer progression, angiogenesis, inflammation regulation, and extracellular matrix remodeling. It also delves into the potential of MMPs as therapeutic targets for cancer therapy and their involvement in various physiological processes such as cell signaling and tissue remodeling.
最新文献
Kidney-specific delivery of a matrix metalloproteinase-2 inhibitory peptide fused to elastin-like polypeptide reduces proteinuria and renal fibrosis in a model of salt-sensitive hypertension

article Full Text OpenAlex

Plasma extracellular vesicle proteomics identifies FN1/F13A1–TGF-β pathway as the major signaling pathway associated with persistent atrial fibrillation

article Full Text OpenAlex

Proteases in intestinal health and disease

review Full Text OpenAlex

CCL28 contributes to angiogenesis and cardiac repair through CCR10+ endothelial cells after myocardial infarction in male mice

article Full Text OpenAlex

Structure–Property Investigation of New “KetoFAPI” Inhibitors of Fibroblast Activation Protein (FAP): Discovery of Highly Potent, Selective Compounds with Prolonged Residence Times and Promising Radiotheranostic Potential

article Full Text OpenAlex

The Urokinase-Type Plasminogen Activator Receptor (uPAR) as a Mediator of Physiological and Pathological Processes: Potential Therapeutic Strategies

review Full Text OpenAlex

Matrix metalloproteinase-driven epithelial-mesenchymal transition: implications in health and disease

review Full Text OpenAlex

Interplay of procoagulatory and neutrophil-derived anticoagulatory proteins in C1q-NET–driven blood coagulation

article Full Text OpenAlex

LRP5: A Multifaceted Co-Receptor in Development, Disease, and Therapeutic Target

review Full Text OpenAlex

Impact of Albumin-Binding Moieties on Structure–Affinity–Pharmacokinetic Relationships of Novel FAP-Targeting Radioligands

article Full Text OpenAlex

近5年高被引文献
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

review Full Text OpenAlex 715 FWCI233.92812398

Matrix Metalloproteinases: From Molecular Mechanisms to Physiology, Pathophysiology, and Pharmacology

review Full Text OpenAlex 423 FWCI56.42195409

Regulation of Collagen I and Collagen III in Tissue Injury and Regeneration

article Full Text OpenAlex 319 FWCI107.09368457

How vascular smooth muscle cell phenotype switching contributes to vascular disease

review Full Text OpenAlex 309 FWCI37.28995487

The Role of Matrix Metalloproteinases (MMP-8, MMP-9, MMP-13) in Periodontal and Peri-Implant Pathological Processes

review Full Text OpenAlex 292 FWCI67.72024666

The Functional Role of Extracellular Matrix Proteins in Cancer

review Full Text OpenAlex 236 FWCI46.47176767

The membrane receptor CD44: novel insights into metabolism

review Full Text OpenAlex 216 FWCI34.44557328

MMP9: A Tough Target for Targeted Therapy for Cancer

review Full Text OpenAlex 216 FWCI29.23065091

Targeting loop3 of sclerostin preserves its cardiovascular protective action and promotes bone formation

article Full Text OpenAlex 178 FWCI24.20025983

A Thrombin‐Activated Peptide‐Templated Nanozyme for Remedying Ischemic Stroke via Thrombolytic and Neuroprotective Actions

article Full Text OpenAlex 176 FWCI23.58665671