专题：Cancer, Hypoxia, and Metabolism

This cluster of papers explores the metabolic reprogramming in cancer cells, focusing on the role of hypoxia-inducible factor 1 (HIF-1), the Warburg effect, tumor hypoxia, glutamine metabolism, and the impact of the tumor microenvironment on cancer cell metabolism. It also delves into oxygen sensing, mitochondrial metabolism, glycolysis inhibition, and the role of hexokinase II in cancer progression.
最新文献
Metabolic reprogramming in cancer: dysregulation of glucose, lipid, and amino acid pathways and therapeutic opportunities

article Full Text OpenAlex

The integrated stress response promotes immune evasion through lipocalin 2

article Full Text OpenAlex

Targeting metabolic-epigenetic-immune axis in cancer: molecular mechanisms and therapeutic implications

article Full Text OpenAlex

Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer

article Full Text OpenAlex

Cancer cachexia: molecular basis and therapeutic advances

article Full Text OpenAlex

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

article Full Text OpenAlex

AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasis

article Full Text OpenAlex

Immune cell metabolic reprogramming in hepatocellular carcinoma: mechanisms, tumor microenvironment, and future immunotherapeutic directions

article Full Text OpenAlex

Metabolic reprogramming signature predicts immunotherapy efficacy in lung adenocarcinoma: Targeting SLC25A1 to overcome immune resistance

article Full Text OpenAlex

Expanding the chemical and therapeutic landscape of 5H-Indeno[1,2-b]pyridin-5-one derivatives: Novel anticancer activity, EGFR inhibition, and modulation of HIF–VEGF and PI3K/AKT/mTOR pathways supported by computational insights

article Full Text OpenAlex

近5年高被引文献
The role of ROS in tumour development and progression

review Full Text OpenAlex 1481 FWCI131.078

The hallmarks of cancer metabolism: Still emerging

review Full Text OpenAlex 1327 FWCI118.2919

Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions

review Full Text OpenAlex 1301 FWCI305.6892

Lactate metabolism in human health and disease

review Full Text OpenAlex 1253 FWCI105.8711

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis

article Full Text OpenAlex 1091 FWCI278.1956

Small molecule metabolites: discovery of biomarkers and therapeutic targets

review Full Text OpenAlex 764 FWCI113.0805

Metabolic programming and immune suppression in the tumor microenvironment

review Full Text OpenAlex 561 FWCI131.7107

Hypoxia-inducible factors: cancer progression and clinical translation

review Full Text OpenAlex 533 FWCI47.8735

The role of lipids in cancer progression and metastasis

review Full Text OpenAlex 527 FWCI45.5619

Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma

article Full Text OpenAlex 522 FWCI124.1056