This cluster of papers covers the epidemiology, classification, treatment, and complications of bone fractures, with a focus on fracture healing, internal fixation techniques, nonunion, infection prevention, biomechanics, pediatric fractures, and soft tissue management. It provides insights into the molecular, spatial, and temporal aspects of fracture healing and the impact of factors such as smoking and inflammation. The cluster also explores limb reconstruction techniques and the economic burden associated with nonunions.