This cluster of papers focuses on the diagnosis, management, and pathogenesis of idiopathic pulmonary fibrosis (IPF), a progressive and fatal lung disease. It covers evidence-based guidelines, cellular and molecular mechanisms of fibrosis, therapeutic translation, treatment trials with drugs like pirfenidone and nintedanib, as well as the role of myofibroblasts and epithelial-mesenchymal transition in lung fibrosis.