This cluster of papers covers a wide range of topics related to Chagas disease, including the epidemiology, genomics, treatment, and control strategies. It discusses the causative agent Trypanosoma cruzi, the impact of Chagas disease in Latin America and non-endemic countries, as well as the challenges of drug resistance and the development of new therapies. Additionally, it explores the clinical aspects such as cardiomyopathy and provides insights into the molecular mechanisms underlying the disease.