专题：Telomeres, Telomerase, and Senescence

This cluster of papers explores the mechanisms and implications of cellular senescence, with a focus on telomere dynamics, tumor suppression, inflammation, DNA damage response, and the potential therapeutic role of senolytics in aging-related diseases.
最新文献
Randomized phase 2b dose-escalation trial of stem cell therapy with laromestrocel for aging frailty

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Induction of senescence during postpartum mammary gland involution supports tissue remodeling and promotes postpartum tumorigenesis

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TRF-1 Mediates PRC2 Function at Ectopic Telomere Repeats in Neurospora crassa

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Characterizing the SASP-Dependent Paracrine Spreading of Senescence Between Human Brain Cell Types

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Protective effect of Florfenicol against DSS-induced ulcerative colitis by inhibiting cellular senescence and reducing inflammation via the AMPK signaling pathway

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Elevated lysosomal mass and enzyme activity in fibroblasts of the Mediterranean mouse Mus spretus

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Efficient near-telomere-to-telomere assembly of nanopore simplex reads

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Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome

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Liver aging and associated diseases

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Source code for "ICE: robust detection of cellular senescence from weak single-cell signatures using imputation-based marker refinement"

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近5年高被引文献
Hallmarks of Cancer: New Dimensions

article Full Text OpenAlex 8551 FWCI972.2143

Hallmarks of aging: An expanding universe

review Full Text OpenAlex 5036 FWCI466.5743

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

review Full Text OpenAlex 1409 FWCI117.4747

Inflammation and aging: signaling pathways and intervention therapies

review Full Text OpenAlex 1120 FWCI199.5392

Cellular senescence: the good, the bad and the unknown

review Full Text OpenAlex 1011 FWCI116.543

Cellular senescence and senolytics: the path to the clinic

review Full Text OpenAlex 958 FWCI106.3249

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

article Full Text OpenAlex 884 FWCI98.4954

Mitochondrial dysfunction in cell senescence and aging

review Full Text OpenAlex 879 FWCI93.5411

Exploiting senescence for the treatment of cancer

review Full Text OpenAlex 802 FWCI91.5739

Senescence and cancer — role and therapeutic opportunities

review Full Text OpenAlex 698 FWCI78.5931