专题：Telomeres, Telomerase, and Senescence

This cluster of papers explores the mechanisms and implications of cellular senescence, with a focus on telomere dynamics, tumor suppression, inflammation, DNA damage response, and the potential therapeutic role of senolytics in aging-related diseases.
最新文献
The senescence-associated secretory phenotype and its physiological and pathological implications

review Full Text OpenAlex

Understanding seasonal telomere length dynamics in hibernating species

review Full Text OpenAlex

Shorter telomere length increases the risk of lymphocyte immunodeficiency: A Mendelian randomization study

article Full Text OpenAlex

Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease

article Full Text OpenAlex

Detection of senescent cells in the mucosal healing process on type 2 diabetic rats after tooth extraction for biomaterial development

article Full Text OpenAlex

Association between leucocyte telomere length and erectile dysfunction in US adults: a secondary study based on 2001–2002 NHANES data

article Full Text OpenAlex

Senolysis of gemcitabine‐induced senescent human pancreatic cancer cells

article Full Text OpenAlex

Downregulated SPESP1‐driven fibroblast senescence decreases wound healing in aged mice

article Full Text OpenAlex

Shaping DNA damage responses: Therapeutic potential of targeting telomeric proteins and DNA repair factors in cancer

article Full Text OpenAlex

Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes

review Full Text OpenAlex

近5年高被引文献
Hallmarks of aging: An expanding universe

review Full Text OpenAlex 4404 FWCI726.16364186

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

review Full Text OpenAlex 1370 FWCI160.70755928

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

review Full Text OpenAlex 1222 FWCI158.73396966

Inflammation and aging: signaling pathways and intervention therapies

review Full Text OpenAlex 925 FWCI275.482837

Cellular senescence: the good, the bad and the unknown

review Full Text OpenAlex 914 FWCI172.31651412

Cellular senescence and senolytics: the path to the clinic

review Full Text OpenAlex 878 FWCI158.31579735

An aged immune system drives senescence and ageing of solid organs

article Full Text OpenAlex 840 FWCI65.958557

The central role of DNA damage in the ageing process

review Full Text OpenAlex 805 FWCI59.20218334

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

article Full Text OpenAlex 768 FWCI143.95608784

Mitochondrial dysfunction in cell senescence and aging

review Full Text OpenAlex 764 FWCI136.95572945