专题：PI3K/AKT/mTOR signaling in cancer

This cluster of papers focuses on the mTOR signaling pathway, particularly its role in growth control, metabolism, and disease, with a specific emphasis on cancer. The PI3K/AKT pathway, Raptor, TSC2, and rapamycin are central to the research discussed in these papers.
最新文献
Updated efficacy of mutant-selective PI3Kα inhibitor RLY-2608 in combination with fulvestrant in patients with PIK3CA -mutant HR+HER2- advanced breast cancer: ReDiscover trial.

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PIK3R1 mutations in individuals with insulin resistance or growth retardation: Case series and in silico functional analysis

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Genomic diversity in functionally relevant genes modifies neurodevelopmental versus neoplastic risks in individuals with germline PTEN variants

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Targeted inhibition of PDGFRA with avapritinib, markedly enhances lenvatinib efficacy in hepatocellular carcinoma in vitro and in vivo: clinical implications

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Modulation of the PI3K/Akt signaling pathway by resveratrol in cancer: molecular mechanisms and therapeutic opportunity

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The phosphorylation of Pak1 by Erk1/2 for cell migration requires Arl4D acting as a scaffolding protein

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Lysosomal EGFR acts as a Rheb-GEF independent of its kinase activity to activate mTORC1

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Case report: Experience of a rare case of primary acute mast cell leukemia

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Repurposing serotonergic drugs for gastric cancer: induction of apoptosis in vitro

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Design, Synthesis, and Biological Evaluation of Pyrrolo[1,2-a]quinoxalin-4(5H)-one Derivatives as Potent and Orally Available Noncovalent Bruton’s Tyrosine Kinase (BTK) Inhibitors

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近5年高被引文献
Targeting PI3K/Akt signal transduction for cancer therapy

review Full Text OpenAlex 969 FWCI20.746

PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer

review Full Text OpenAlex 823 FWCI51.398

Kinase drug discovery 20 years after imatinib: progress and future directions

review Full Text OpenAlex 801 FWCI36.162

Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRAS G12C Mutation

article Full Text OpenAlex 614 FWCI64.093

Regulation and metabolic functions of mTORC1 and mTORC2

review Full Text OpenAlex 495 FWCI12.348

PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?

review Full Text OpenAlex 484 FWCI18.201

Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

review Full Text OpenAlex 408 FWCI9.451

Capivasertib in Hormone Receptor–Positive Advanced Breast Cancer

article Full Text OpenAlex 373 FWCI137.25

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

article Full Text OpenAlex 362 FWCI27.46

Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

review Full Text OpenAlex 359 FWCI22.433