专题：Liver physiology and pathology

This cluster of papers explores the mechanisms, cellular players, and therapeutic targets related to liver fibrosis. It covers topics such as the role of hepatic stellate cells, liver regeneration, TGF-ß signaling, macrophage involvement, MET signaling, oxidative stress, angiogenesis, hepatocyte growth factor, and inflammation in the pathogenesis and treatment of liver fibrosis.
最新文献
The Dilemma of Choice: Options for Nonoperable Hepatocellular Carcinoma Management

article Full Text OpenAlex

Four-year overall survival update from the phase III HIMALAYA study of tremelimumab plus durvalumab in unresectable hepatocellular carcinoma

article Full Text OpenAlex

Design, synthesis and pharmacological evaluation of novel thiazole derivatives as c-Met kinase inhibitors and anticancer agents

article Full Text OpenAlex

Design and synthesis of novel JNK inhibitors targeting liver pyruvate kinase for the treatment of non-alcoholic fatty liver disease and hepatocellular carcinoma

article Full Text OpenAlex

Reprogramming tumor-associated macrophages and inhibiting tumor neovascularization by targeting MANF–HSF1–HSP70-1 pathway: An effective treatment for hepatocellular carcinoma

article Full Text OpenAlex

Genomic and Immune Landscape Comparison of MET Exon 14 Skipping and MET-Amplified Non-small Cell Lung Cancer

article Full Text OpenAlex

Angiotensin-converting enzyme 2 and AMPK/mTOR pathway in the treatment of liver fibrosis: Should we consider further implications?

editorial Full Text OpenAlex

Advances in Noninvasive Molecular Imaging Probes for Liver Fibrosis Diagnosis

article Full Text OpenAlex

In Situ Self-Assembling Liver Spheroids with Synthetic Nanoscaffolds for Preclinical Drug Screening Applications

article Full Text OpenAlex

Validating Well-Functioning Hepatic Organoids for Toxicity Evaluation

article Full Text OpenAlex

近5年高被引文献
Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial

article Full Text OpenAlex 990 FWCI130.72374336

Targeting TGF-β signal transduction for fibrosis and cancer therapy

review Full Text OpenAlex 834 FWCI103.00888523

Hepatic inflammatory responses in liver fibrosis

review Full Text OpenAlex 513 FWCI180.76385098

Targeting fibrosis: mechanisms and clinical trials

review Full Text OpenAlex 397 FWCI81.34470143

Donafenib Versus Sorafenib in First-Line Treatment of Unresectable or Metastatic Hepatocellular Carcinoma: A Randomized, Open-Label, Parallel-Controlled Phase II-III Trial

article Full Text OpenAlex 366 FWCI45.73709135

Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

article Full Text OpenAlex 361 FWCI72.46512566

Hepatic fibrosis 2022: Unmet needs and a blueprint for the future

review Full Text OpenAlex 346 FWCI52.83009207

Cholangiocyte organoids can repair bile ducts after transplantation in the human liver

article Full Text OpenAlex 328 FWCI41.35800814

Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts

article Full Text OpenAlex 324 FWCI25.68371593

Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH

article Full Text OpenAlex 319 FWCI42.56275969