专题：Ubiquitin and proteasome pathways

This cluster of papers focuses on the Ubiquitin-Proteasome Proteolytic Pathway, exploring mechanisms of protein degradation, regulation of E3 Ubiquitin Ligases, roles of Deubiquitinating Enzymes, and the impact of SUMOylation. It also delves into the development of proteasome inhibitors for cancer therapy and the involvement of this pathway in NF-?B activation.
最新文献
Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry

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The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction

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Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage

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Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia

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MTAP-Null Tumors: A Comprehensive Review on Synthetic Vulnerabilities and Therapeutic Strategies

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UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6

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Inhibitors supercharge kinase turnover through native proteolytic circuits

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USP1–TRAF2 axis–regulated mortalin stability mediates chemoresistance by disrupting calcium transport in peripheral T-cell lymphoma

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A UBH-UBX module amplifies p97/VCP’s unfolding power to facilitate protein extraction and degradation

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USP22 drives tumor immune evasion and checkpoint blockade resistance through EZH2-mediated epigenetic silencing of MHC-I

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近5年高被引文献
PROTAC targeted protein degraders: the past is prologue

review Full Text OpenAlex 2788 FWCI226.2067

Cell cycle regulation: p53-p21-RB signaling

review Full Text OpenAlex 1167 FWCI120.8881

Harnessing protein folding neural networks for peptide–protein docking

article Full Text OpenAlex 1153 FWCI97.0822

Angiogenic signaling pathways and anti-angiogenic therapy for cancer

review Full Text OpenAlex 1067 FWCI167.321

Diagnosis and Management of Multiple Myeloma

review Full Text OpenAlex 911 FWCI138.7104

BindingDB Entry 50022536: Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.

article Full Text OpenAlex 844 FWCI0

Targeting p53 pathways: mechanisms, structures and advances in therapy

review Full Text OpenAlex 800 FWCI186.4344

Targeted protein degradation: mechanisms, strategies and application

review Full Text OpenAlex 789 FWCI62.6085

Control of protein stability by post-translational modifications

review Full Text OpenAlex 681 FWCI106.9734

Evolving therapeutic landscape of advanced hepatocellular carcinoma

review Full Text OpenAlex 662 FWCI54.8755