专题：Ubiquitin and proteasome pathways

This cluster of papers focuses on the Ubiquitin-Proteasome Proteolytic Pathway, exploring mechanisms of protein degradation, regulation of E3 Ubiquitin Ligases, roles of Deubiquitinating Enzymes, and the impact of SUMOylation. It also delves into the development of proteasome inhibitors for cancer therapy and the involvement of this pathway in NF-?B activation.
最新文献
The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction

article Full Text OpenAlex

Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage

article Full Text OpenAlex

Editorial: Decoding Gut Failure in Cirrhosis: Villin‐1 and the Emergence of a Seventh Organ Failure

article Full Text OpenAlex

Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia

article Full Text OpenAlex

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

article Full Text OpenAlex

Targeting STING to generate therapeutic anti-tumor immunity

article Full Text OpenAlex

SUMO1 promotes malignancy and chemoresistance in colorectal cancer: Clinical and functional evidence

article Full Text OpenAlex

Impact of somatic XIST deletions on ongoing XIST expression and inactive X silencing and heterochromatin

article Full Text OpenAlex

Sacituzumab Govitecan in Untreated, Advanced Triple-Negative Breast Cancer

article Full Text OpenAlex

A novel ubiquitination-based molecular signature predicts prognosis in diffuse large B-cell lymphoma

article Full Text OpenAlex

近5年高被引文献
PROTAC targeted protein degraders: the past is prologue

review Full Text OpenAlex 2638 FWCI319.73367243

Harnessing protein folding neural networks for peptide–protein docking

article Full Text OpenAlex 1128 FWCI137.34518031

Cell cycle regulation: p53-p21-RB signaling

review Full Text OpenAlex 1119 FWCI171.30939942

Angiogenic signaling pathways and anti-angiogenic therapy for cancer

review Full Text OpenAlex 981 FWCI182.14266989

Diagnosis and Management of Multiple Myeloma

review Full Text OpenAlex 862 FWCI194.0104501

BindingDB Entry 50022536: Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.

article Full Text OpenAlex 844 FWCI0

Targeting p53 pathways: mechanisms, structures and advances in therapy

review Full Text OpenAlex 734 FWCI173.68342641

Targeted protein degradation: mechanisms, strategies and application

review Full Text OpenAlex 729 FWCI88.7328629

Evolving therapeutic landscape of advanced hepatocellular carcinoma

review Full Text OpenAlex 637 FWCI77.77970784

Control of protein stability by post-translational modifications

review Full Text OpenAlex 633 FWCI117.71503844