专题：Ubiquitin and proteasome pathways

This cluster of papers focuses on the Ubiquitin-Proteasome Proteolytic Pathway, exploring mechanisms of protein degradation, regulation of E3 Ubiquitin Ligases, roles of Deubiquitinating Enzymes, and the impact of SUMOylation. It also delves into the development of proteasome inhibitors for cancer therapy and the involvement of this pathway in NF-?B activation.
最新文献
The maternal PADI6–UHRF1–UBE2D complex regulates ubiquitination during oocyte maturation and embryogenesis

article Full Text OpenAlex

NSUN6 deficiency drives immune suppression in pancreatic cancer via the KDM5A-CCL2-macrophage axis

article Full Text OpenAlex

The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction

article Full Text OpenAlex

Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage

article Full Text OpenAlex

The mechanistic basis and cellular functions of UFMylation

article Full Text OpenAlex

Multi-scale classification decodes the complexity of the human E3 ligome

article Full Text OpenAlex

Targeting ubiquitination in disease and therapy

article Full Text OpenAlex

Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization

article Full Text OpenAlex

N6-Methyladenosine: an RNA modification as a central regulator of cancer

article Full Text OpenAlex

Deubiquitinating enzyme JOSD2 modulates cGAS to facilitate immune evasion in colorectal cancer

article Full Text OpenAlex

近5年高被引文献
PROTAC targeted protein degraders: the past is prologue

review Full Text OpenAlex 2924 FWCI225.7344

Cell cycle regulation: p53-p21-RB signaling

review Full Text OpenAlex 1210 FWCI120.2953

Harnessing protein folding neural networks for peptide–protein docking

article Full Text OpenAlex 1176 FWCI96.8795

Angiogenic signaling pathways and anti-angiogenic therapy for cancer

review Full Text OpenAlex 1138 FWCI167.9969

Teclistamab in Relapsed or Refractory Multiple Myeloma

article Full Text OpenAlex 1054 FWCI151.6465

Targeting p53 pathways: mechanisms, structures and advances in therapy

review Full Text OpenAlex 847 FWCI186.0293

BindingDB Entry 50022536: Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.

article Full Text OpenAlex 844 FWCI0

Targeted protein degradation: mechanisms, strategies and application

review Full Text OpenAlex 842 FWCI62.4777

Control of protein stability by post-translational modifications

review Full Text OpenAlex 715 FWCI105.8084

Evolving therapeutic landscape of advanced hepatocellular carcinoma

review Full Text OpenAlex 694 FWCI54.9475