专题：Ubiquitin and proteasome pathways

This cluster of papers focuses on the Ubiquitin-Proteasome Proteolytic Pathway, exploring mechanisms of protein degradation, regulation of E3 Ubiquitin Ligases, roles of Deubiquitinating Enzymes, and the impact of SUMOylation. It also delves into the development of proteasome inhibitors for cancer therapy and the involvement of this pathway in NF-?B activation.
最新文献
Targeting ROS in cancer: rationale and strategies

review Full Text OpenAlex

UBE2S promotes glycolysis in hepatocellular carcinoma by enhancing E3 enzyme-independent polyubiquitination of VHL

article Full Text OpenAlex

Ubiquitin E3 ligases assisted technologies in protein degradation: Sharing pathways in neurodegenerative disorders and cancer

article Full Text OpenAlex

The role of deubiquitinases in cardiac disease

review Full Text OpenAlex

PTMs of PD-1/PD-L1 and PROTACs application for improving cancer immunotherapy

article Full Text OpenAlex

TRAF6 enhances PD-L1 expression through YAP1-TFCP2 signaling in melanoma

article Full Text OpenAlex

Dominant negative OTULIN-related autoinflammatory syndrome

article Full Text OpenAlex

A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome

article Full Text OpenAlex

Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension

article Full Text OpenAlex

TUBB, a robust biomarker with satisfying abilities in diagnosis, prognosis, and immune regulation via a comprehensive pan-cancer analysis

article Full Text OpenAlex

近5年高被引文献
PROTAC targeted protein degraders: the past is prologue

review Full Text OpenAlex 2520 FWCI310.01120895

Harnessing protein folding neural networks for peptide–protein docking

article Full Text OpenAlex 1115 FWCI136.23755789

Cell cycle regulation: p53-p21-RB signaling

review Full Text OpenAlex 1069 FWCI165.94667039

Angiogenic signaling pathways and anti-angiogenic therapy for cancer

review Full Text OpenAlex 906 FWCI168.21738932

BindingDB Entry 50022536: Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.

article Full Text OpenAlex 844 FWCI0

Diagnosis and Management of Multiple Myeloma

review Full Text OpenAlex 829 FWCI189.0703692

The MYC oncogene — the grand orchestrator of cancer growth and immune evasion

review Full Text OpenAlex 813 FWCI54.42309441

Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†

article Full Text OpenAlex 745 FWCI106.93793712

Targeted protein degradation: mechanisms, strategies and application

review Full Text OpenAlex 699 FWCI86.02534143

Targeting p53 pathways: mechanisms, structures and advances in therapy

review Full Text OpenAlex 682 FWCI161.32838103