专题：Ubiquitin and proteasome pathways

This cluster of papers focuses on the Ubiquitin-Proteasome Proteolytic Pathway, exploring mechanisms of protein degradation, regulation of E3 Ubiquitin Ligases, roles of Deubiquitinating Enzymes, and the impact of SUMOylation. It also delves into the development of proteasome inhibitors for cancer therapy and the involvement of this pathway in NF-?B activation.
最新文献
Unveiling the hidden interactome of CRBN molecular glues

article Full Text OpenAlex

Mining the CRBN target space redefines rules for molecular glue–induced neosubstrate recognition

article Full Text OpenAlex

Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma

article Full Text OpenAlex

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

article Full Text OpenAlex

The TP53 tumor suppressor gene: From molecular biology to clinical investigations

review Full Text OpenAlex

BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction

article Full Text OpenAlex

Trim45: An emerging E3 ubiquitin ligases in cancer

review Full Text OpenAlex

The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility

article Full Text OpenAlex

DNA nanoflower Oligo-PROTAC for targeted degradation of FUS to treat neurodegenerative diseases

article Full Text OpenAlex

A family of E3 ligases extend K11 polyubiquitin on sites of MARUbylation

preprint Full Text OpenAlex

近5年高被引文献
PROTAC targeted protein degraders: the past is prologue

review Full Text OpenAlex 2138 FWCI73.015

Harnessing protein folding neural networks for peptide–protein docking

article Full Text OpenAlex 951 FWCI91.101

Cell cycle regulation: p53-p21-RB signaling

review Full Text OpenAlex 826 FWCI34.638

Diagnosis and Management of Multiple Myeloma

review Full Text OpenAlex 710 FWCI42.119

Angiogenic signaling pathways and anti-angiogenic therapy for cancer

review Full Text OpenAlex 688 FWCI36.514

Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†

article Full Text OpenAlex 669 FWCI96.67

The MYC oncogene — the grand orchestrator of cancer growth and immune evasion

review Full Text OpenAlex 641 FWCI13.673

Post-translational modifications in proteins: resources, tools and prediction methods

article Full Text OpenAlex 595 FWCI38.372

IFI16-dependent STING signaling is a crucial regulator of anti-HER2 immune response in HER2+ breast cancer

article Full Text OpenAlex 551 FWCI61.335

Targeted protein degradation: mechanisms, strategies and application

review Full Text OpenAlex 540 FWCI18.105