专题:Inflammasome and immune disorders

This cluster of papers focuses on the molecular mechanisms of inflammasome activation, regulation, and its role in inflammatory responses, cell death (pyroptosis), and immune-related diseases. It covers topics such as NLRP3 inflammasome, interleukin-1, caspase-1, and the involvement of mitochondria in inflammasome activation.
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Implication of xanthine oxidoreductase in oxidative stress-related chronic diseases

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PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling

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Regulation of STING activation by phosphoinositide and cholesterol

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Zinc‐Complex Orchestrating Pyroptosis for Hypoxia‐Tolerant Photoimmunotherapy

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Mitochondrial dysfunction–induced PANoptosis: Mechanisms, triggers, and disease implications

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Identification of Chlamydia pneumoniae and NLRP3 inflammasome activation in Alzheimer’s disease retina

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Chemiluminescence‐Powered Immunotherapy for Deep Tumors: Promoting PD‐L1 Degradation and Igniting Pyroptosis Through Subcellular Trafficking and Targeting

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Crosstalk between cGAS-STING and pyroptosis: From molecular mechanisms to therapeutic strategies

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Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage

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Opportunities and challenges of targeting cGAS–STING in cancer

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