专题：Protein purification and stability

This cluster of papers focuses on the analysis, mechanisms, and control of protein aggregation in biopharmaceuticals, particularly recombinant proteins and therapeutic antibodies. It also delves into the stability, chromatographic purification, immunogenicity, and refolding of these proteins, as well as the use of sedimentation velocity for size-distribution analysis.
最新文献
Process and purification synergies with data analytics driving clinical translation in nanomedicine

article Full Text OpenAlex

Evaluating Dextrose-Derived Interference in Low-Concentration Monoclonal Antibody Quantification for Clinical In-Use Studies

article Full Text OpenAlex

Total Breakthrough Strategy in Hydrophilic Interaction Chromatography for IP‐RPLC × HILIC Separation of Oligonucleotides

article Full Text OpenAlex

The integration of artificial intelligence through quality by digital design for sustainable pharmaceutical manufacturing

article Full Text OpenAlex

Unlabeled NMR Approach with Site-Specific Methyl Assignments for Structural Evaluation of the IgG1 Fc Region

article Full Text OpenAlex

NXTAGE: a phase 1/2 study of NXT007 to assess safety, pharmacokinetics, and efficacy in hemophilia A without inhibitors

article Full Text OpenAlex

Strategies for enhancing protein solubility: methods, applications, and prospects

article Full Text OpenAlex

A self-cleavable ULP1-SUMO fusion strategy for enhanced soluble protein expression and one-step purification in Escherichia coli

article Full Text OpenAlex

Magnet-assisted immunoprecipitation (MAIP) of recombinant protein v1

article Full Text OpenAlex

GMP-compliant batch manufacturing of dextran-coated iron oxide nanoparticles: A process development case study

article Full Text OpenAlex

近5年高被引文献
NANOBODIES®: A Review of Diagnostic and Therapeutic Applications

review Full Text OpenAlex 333 FWCI75.6656

Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

article Full Text OpenAlex 320 FWCI28.533

Improving Protein Expression, Stability, and Function with ProteinMPNN

article Full Text OpenAlex 273 FWCI59.6459

Designing antibodies as therapeutics

review Full Text OpenAlex 257 FWCI33.4254

Pharmaceutical Pelletization Technology

article Full Text OpenAlex 241 FWCI3.8318

Kinetic Modeling to Explain the Release of Medicine from Drug Delivery Systems

article Full Text OpenAlex 230 FWCI21.2226

Antibody Response to Omicron BA.4–BA.5 Bivalent Booster

letter Full Text OpenAlex 207 FWCI38.7109

Atomically accurate de novo design of antibodies with RFdiffusion

preprint Full Text OpenAlex 183 FWCI0

Computational and artificial intelligence-based methods for antibody development

review Full Text OpenAlex 174 FWCI38.5651

Stability characterization for pharmaceutical liposome product development with focus on regulatory considerations: An update

review Full Text OpenAlex 166 FWCI11.8038