专题：Protein purification and stability

This cluster of papers focuses on the analysis, mechanisms, and control of protein aggregation in biopharmaceuticals, particularly recombinant proteins and therapeutic antibodies. It also delves into the stability, chromatographic purification, immunogenicity, and refolding of these proteins, as well as the use of sedimentation velocity for size-distribution analysis.
最新文献
Optimization of Antibiotic Selection: ABC and VED Analysis of Medicines Against Intracellular Microorganisms

article Full Text OpenAlex

A Coarse-Grained MD Model for Disorder-To-Order Transitions in PolyQ Aggregation

article Full Text OpenAlex

Investigating the Effects of pH and Temperature on the Properties of Lysozyme–Polyacrylic Acid Complexes via Molecular Simulations

article Full Text OpenAlex

Mechanistic modeling of lipid nanoparticle formation for the delivery of nucleic acid therapeutics

review Full Text OpenAlex

High‐Throughput Pipeline for Protein Expression and Solubility Profiling Using Synthetically Generated Plasmids

article Full Text OpenAlex

A Robust and Accurate Filter Paper–Based Dried Plasma Spot Method for Bictegravir Monitoring in HIV Therapy

article Full Text OpenAlex

Analytical Data and Single-Dose PK are Sufficient to Conclude Comparable Immunogenicity for Biosimilars: An Ustekinumab Case Study

review Full Text OpenAlex

Recent Progress in Supersaturation-based SNEDDS: Formulation, Mechanism, and Biopharmaceutical Performance

article Full Text OpenAlex

Advancing therapeutic monoclonal antibody analysis: A sequential injection lab-on-valve approach

article Full Text OpenAlex

Phage Therapy as an Alternative to Antibiotics: Harnessing Phages in Oral Medicine

article Full Text OpenAlex

近5年高被引文献
Polyethylene Glycol Immunogenicity: Theoretical, Clinical, and Practical Aspects of Anti-Polyethylene Glycol Antibodies

article Full Text OpenAlex 388 FWCI48.571

Pharmaceutical amorphous solid dispersion: A review of manufacturing strategies

review Full Text OpenAlex 385 FWCI7.411

Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

article Full Text OpenAlex 248 FWCI27.305

Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties

review Full Text OpenAlex 244 FWCI5.094

Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

review Full Text OpenAlex 241 FWCI4.709

NANOBODIES®: A Review of Diagnostic and Therapeutic Applications

review Full Text OpenAlex 220 FWCI18.408

Challenges Associated With the Formation of Recombinant Protein Inclusion Bodies in Escherichia coli and Strategies to Address Them for Industrial Applications

review Full Text OpenAlex 217 FWCI4.655

Response surface methodology: A review on its applications and challenges in microbial cultures

review Full Text OpenAlex 216 FWCI4.655

Nanoparticles for Drug Delivery

article Full Text OpenAlex 207 FWCI1.015

Structural and Biochemical Features of Human Serum Albumin Essential for Eukaryotic Cell Culture

review Full Text OpenAlex 198 FWCI4.275