专题：Protein purification and stability

This cluster of papers focuses on the analysis, mechanisms, and control of protein aggregation in biopharmaceuticals, particularly recombinant proteins and therapeutic antibodies. It also delves into the stability, chromatographic purification, immunogenicity, and refolding of these proteins, as well as the use of sedimentation velocity for size-distribution analysis.
最新文献
Immune Response Mechanisms in Haemophilia A

article Full Text OpenAlex

Unlabeled NMR Approach with Site-Specific Methyl Assignments for Structural Evaluation of the IgG1 Fc Region

article Full Text OpenAlex

Rethinking the Iodine Reaction Methodology in the Classic Starch Degradation Experiment

article Full Text OpenAlex

Strategies for enhancing protein solubility: methods, applications, and prospects

article Full Text OpenAlex

High concentration subcutaneous biological drug products: challenges and advancements

article Full Text OpenAlex

New equations of column performance in liquid chromatography

article Full Text OpenAlex

Fine-tuning of leaky expression delivers soluble and functional recombinant alphainterferon in the cytoplasm of Escherichia coli

article Full Text OpenAlex

Magnet-assisted immunoprecipitation (MAIP) of recombinant protein v1

article Full Text OpenAlex

Molecular Mechanisms of Liraglutide Aggregation Induced by Dual Air–Water and Silicone-Oil–Water Interfacial Stress

article Full Text OpenAlex

Enhanced lentiviral vector recovery and separation using arginine hydrochloride with CIM QA monoliths

article Full Text OpenAlex

近5年高被引文献
NANOBODIES®: A Review of Diagnostic and Therapeutic Applications

review Full Text OpenAlex 314 FWCI73.4054

Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

article Full Text OpenAlex 302 FWCI28.6278

Improving Protein Expression, Stability, and Function with ProteinMPNN

article Full Text OpenAlex 249 FWCI60.0258

Designing antibodies as therapeutics

review Full Text OpenAlex 241 FWCI32.7072

Pharmaceutical Pelletization Technology

article Full Text OpenAlex 241 FWCI3.5398

Kinetic Modeling to Explain the Release of Medicine from Drug Delivery Systems

article Full Text OpenAlex 207 FWCI20.0457

Antibody Response to Omicron BA.4–BA.5 Bivalent Booster

letter Full Text OpenAlex 205 FWCI39.9425

Atomically accurate de novo design of antibodies with RFdiffusion

preprint Full Text OpenAlex 178 FWCI0

Computational and artificial intelligence-based methods for antibody development

review Full Text OpenAlex 170 FWCI39.4259

Stability characterization for pharmaceutical liposome product development with focus on regulatory considerations: An update

review Full Text OpenAlex 158 FWCI11.7031