专题：Adenosine and Purinergic Signaling

This cluster of papers focuses on the molecular physiology and pharmacology of purinergic signalling, including the role of adenosine receptors, P2X receptors, and nucleotide signalling in immune suppression, inflammation, neuroprotection, and the tumor microenvironment. It explores the potential therapeutic targets related to purinergic signalling.
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The P2X7 receptor/NLRP3 inflammasome signaling axis in sepsis: molecular mechanisms, organ-specific pathophysiology, and emerging therapeutic strategies

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The potential role of adenosinergic pathway and methylxanthines in Parkinson’s disease: Blowing in the wind or not

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Development and biomedical imaging applications of small-molecule fluorescent probes targeting epilepsy biomarkers

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Glial Activation, Neuroinflammation, and Loss of Neuroprotection in Chronic Pain: Cellular Mechanisms and Emerging Therapeutic Strategies

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Vagus nerve-mediated neuroimmune modulation for rheumatoid arthritis: a pivotal randomized controlled trial

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Perineural invasion as a neuro−immune niche in head and neck cancer: mechanisms of immune evasion and therapeutic implications

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Reversing adenosine-mediated immunosuppression in triple-negative breast cancer by synergistic chemo-immunotherapy via stimuli-responsive nanomedicines

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Understanding interspecies drug response variations between human and rodent P2X7 receptors

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Celecoxib in oncology: targeting the COX-2/PGE2 axis to reprogram the tumor immune microenvironment and enhance multimodal therapy

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Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis

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