专题：Adenosine and Purinergic Signaling

This cluster of papers focuses on the molecular physiology and pharmacology of purinergic signalling, including the role of adenosine receptors, P2X receptors, and nucleotide signalling in immune suppression, inflammation, neuroprotection, and the tumor microenvironment. It explores the potential therapeutic targets related to purinergic signalling.
最新文献
CD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12+ microglia transformation

article Full Text OpenAlex

TNFα impairs platelet function by inhibiting autophagy and disrupting metabolism via Syntaxin-17 downregulation

article Full Text OpenAlex

Comprehensive genetic analysis and genotype–phenotype correlations in pediatric patients with atypical hemolytic uremic syndrome

article Full Text OpenAlex

The effect of CTLA4-Ig on fibrotic progression in a murine model of chronic lung allograft dysfunction

article Full Text OpenAlex

GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy

article Full Text OpenAlex

A new 3-arylbenzofuran derivative EIE-2 reestablishes Treg-dependent tolerance in rheumatoid arthritis by targeting on Syk induced mTOR and PKCθ imbalance

article Full Text OpenAlex

Insights Into Heart-Tumor Interactions in Heart Failure

review Full Text OpenAlex

The progress and prospects of targeting the adenosine pathway in cancer immunotherapy

review Full Text OpenAlex

PHGDH-mediated serine synthesis in astrocytes supports neuroinflammation by sustaining NADH level to promote histone acetylation

article Full Text OpenAlex

Selective, Non-nucleotidic Radiotracer for P2Y12 Receptors: Design, Synthesis, Characterization, and Imaging of Brain Slices

article Full Text OpenAlex

近5年高被引文献
From purines to purinergic signalling: molecular functions and human diseases

review Full Text OpenAlex 327 FWCI11.58

Autophagy in tumour immunity and therapy

review Full Text OpenAlex 301 FWCI11.681

Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria

article Full Text OpenAlex 287 FWCI24.816

Epigenetic regulation in cardiovascular disease: mechanisms and advances in clinical trials

review Full Text OpenAlex 238 FWCI8.618

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia

article Full Text OpenAlex 229 FWCI21.079

Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice

article Full Text OpenAlex 223 FWCI20.772

Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease

article Full Text OpenAlex 206 FWCI24.768

Nucleotide metabolism: a pan-cancer metabolic dependency

review Full Text OpenAlex 204 FWCI12.69

Adenosine and Adenine Nucleotides As Regulators of Cellular Function

book Full Text OpenAlex 198 FWCI1.25

Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology

article Full Text OpenAlex 198 FWCI17.805