专题:Adenosine and Purinergic Signaling

This cluster of papers focuses on the molecular physiology and pharmacology of purinergic signalling, including the role of adenosine receptors, P2X receptors, and nucleotide signalling in immune suppression, inflammation, neuroprotection, and the tumor microenvironment. It explores the potential therapeutic targets related to purinergic signalling.
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CD39/CD73-mediated immunosuppression and tumor aggressiveness in bladder cancer

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Genetically encoded manipulation of ATP/ADP ratio in human cells uncovers proteomic and physiological signatures of energy stress

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Quemliclustat and chemotherapy with or without zimberelimab in metastatic pancreatic adenocarcinoma: a randomized phase 1 trial

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Redefining nucleotide-binding oligomerization domain-like receptors: from immune sentinels to multifunctional regulators

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Design strategies and recent advances in activatable small molecule therapeutics

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Emerging roles of immune cell-derived neurotransmitters in immunity and disease

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The P2X7 receptor/NLRP3 inflammasome signaling axis in sepsis: molecular mechanisms, organ-specific pathophysiology, and emerging therapeutic strategies

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The potential role of adenosinergic pathway and methylxanthines in Parkinson’s disease: Blowing in the wind or not

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Simultaneous Detection and Quantification of Adenine Nucleotides in Mammalian Cultured Cells by HPLC

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Development and biomedical imaging applications of small-molecule fluorescent probes targeting epilepsy biomarkers

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