专题:Adenosine and Purinergic Signaling

This cluster of papers focuses on the molecular physiology and pharmacology of purinergic signalling, including the role of adenosine receptors, P2X receptors, and nucleotide signalling in immune suppression, inflammation, neuroprotection, and the tumor microenvironment. It explores the potential therapeutic targets related to purinergic signalling.
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CD39/CD73/A2AR pathway and cancer immunotherapy

article Full Text OpenAlex 402 FWCI63.4359

Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity

article Full Text OpenAlex 268 FWCI19.9642

Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions

article Full Text OpenAlex 265 FWCI15.2485

Uric acid in health and disease: From physiological functions to pathogenic mechanisms

article Full Text OpenAlex 239 FWCI58.5195

Community guidelines for GPCR ligand bias: IUPHAR review 32

article Full Text OpenAlex 228 FWCI12.6263

De novo and salvage purine synthesis pathways across tissues and tumors

article Full Text OpenAlex 206 FWCI23.6104

Adenosine and Adenine Nucleotides As Regulators of Cellular Function

book Full Text OpenAlex 198 FWCI1.28

Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy

article Full Text OpenAlex 187 FWCI10.9003

Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy

article Full Text OpenAlex 182 FWCI19.3363

Adenosine-A2A Receptor Pathway in Cancer Immunotherapy

article Full Text OpenAlex 177 FWCI18.3598