专题：Ion Channels and Receptors

This cluster of papers focuses on the role of calcium signaling and ion channels, particularly TRP channels, in sensory neurons and their involvement in thermosensation, nociception, and the pain pathway. It also explores the function of store-operated channels, Orai1, and STIM1 in calcium homeostasis and signaling. The papers cover a wide range of topics related to calcium signaling in sensory perception and disease.
最新文献
TRPM8 modulation alters uptake of Transferrin-mediated Fe3+, mitochondrial Fe2+ and intracellular Ca2+-levels in microglia

article Full Text OpenAlex

Small molecule agonist TPC2-A1-N increases intracellular Ca2+ independent of Two-Pore Channels

article Full Text OpenAlex

Thermoring basis for thermo-gated TRPV2

preprint Full Text OpenAlex

Spicy Compounds Induce Convergent Transcriptional Responses in the Mouse Parabrachial Nucleus

article Full Text OpenAlex

Muscarinic Receptor Antagonism and TRPM3 Activation as Stimulators of Mitochondrial Function and Axonal Repair in Diabetic Sensorimotor Polyneuropathy

review Full Text OpenAlex

Rapid Detection of Chemical Constituents of Capsicum chinense (Chile Habanero) and Capsicum pubescens (Chile Manzano) Extracts Obtained from Maceration and Ultrasonic Bath Extraction Methods

article Full Text OpenAlex

5‐HT7 antagonists confer analgesia via suppression of neurotrophin overproduction in submucosal nerves of mouse models with visceral hypersensitivity

article Full Text OpenAlex

Insights into early cochlear damage induced by potassium channel deficiency

article Full Text OpenAlex

Proof of Pharmacology, Safety, and Pharmacokinetics of the Novel TRPA1 Antagonist BI 1839100: A Randomized, Placebo‐Controlled, Parallel Group, First‐In‐Human Study in Healthy Male Participants

article Full Text OpenAlex

STIM-IP3R crosstalk regulates migration of breast cancer cells

article Full Text OpenAlex

近5年高被引文献
Advances in TRP channel drug discovery: from target validation to clinical studies

review Full Text OpenAlex 420 FWCI18.422

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases

review Full Text OpenAlex 264 FWCI23.655

Cough hypersensitivity and chronic cough

review Full Text OpenAlex 217 FWCI13.06

NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation

article Full Text OpenAlex 208 FWCI13.543

Structural snapshots of TRPV1 reveal mechanism of polymodal functionality

article Full Text OpenAlex 187 FWCI19.007

TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway

article Full Text OpenAlex 182 FWCI17.308

Heat-dependent opening of TRPV1 in the presence of capsaicin

article Full Text OpenAlex 176 FWCI17

Advances and challenges in therapeutic targeting of NRF2

review Full Text OpenAlex 162 FWCI8.88

Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection

article Full Text OpenAlex 143 FWCI32.215

Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel

article Full Text OpenAlex 139 FWCI13.576