This cluster of papers focuses on the epidemiology, mechanisms of infection, treatment options, and antimicrobial resistance of urinary tract infections (UTIs). It covers topics such as catheter-associated UTIs, uropathogenic Escherichia coli, asymptomatic bacteriuria, prevention strategies, the urinary microbiome, and the use of fosfomycin. The papers also discuss clinical practice guidelines for the management of UTIs in different patient populations.