This cluster of papers focuses on the bioavailability, health effects, and therapeutic potential of curcumin, a natural compound with antioxidant, anti-inflammatory, and potential anticancer properties. The papers cover various aspects including its molecular targets, clinical trials, nanoparticle encapsulation for improved delivery, neuroprotective effects, and pharmacokinetics. The research explores the application of curcumin in the prevention and treatment of various diseases such as cancer, neurodegenerative diseases, cardiovascular diseases, and diabetes.