专题：Prion Diseases and Protein Misfolding

This cluster of papers focuses on the causes, molecular basis, detection, transmission, and potential treatments for prion diseases, including variant Creutzfeldt-Jakob disease. It explores the role of infectious prions, protein misfolding, and their impact on neurodegenerative diseases. The research also delves into the pathology of these diseases and their transmissibility through blood transfusion.
最新文献
A self-complementary recombinant adeno-associated virus vector coding for an anchorless prion protein carrying the G127V mutation extends survival in a rodent prion disease model

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abstract screening results

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Dolutegravir Reduces Human T-Cell Lymphotropic Virus Type 1 Proviral Load and Improves Neurological Outcomes in a Phase 2 Controlled Trial

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Interplay between Local Diffusion, Concentration, and Inter-Protein Alignment Promotes Cross-β-Sheet Transitions at Condensate Interfaces

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The amyloid packing difference: a pairwise comparison metric for amyloid structures

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Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategy

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Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity

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Best practice recommendations for laboratory analysis and reporting of cerebrospinal fluid oligoclonal banding and associated tests for multiple sclerosis (MS): a consensus report from the harmonized CSF analysis for MS investigation (hCAMI) subcommittee of the Canadian society of clinical chemists (CSCC)

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Consequences of prion strain mixtures: Indifference, competition, or collusion

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Human Prion Disease: Pathogenesis, Diagnosis and Public Health

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近5年高被引文献
Cryo-EM structures of amyloid-β 42 filaments from human brains

article Full Text OpenAlex 422 FWCI49.6579

Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis

review Full Text OpenAlex 373 FWCI42.8476

In vivo staging of regional amyloid deposition

article Full Text OpenAlex 309 FWCI13.3556

Amyloid nomenclature 2022: update, novel proteins, and recommendations by the International Society of Amyloidosis (ISA) Nomenclature Committee

article Full Text OpenAlex 308 FWCI25.5675

Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer’s Disease

review Full Text OpenAlex 302 FWCI52.1342

Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids

review Full Text OpenAlex 251 FWCI43.4712

Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations

article Full Text OpenAlex 235 FWCI18.3707

Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro

article Full Text OpenAlex 182 FWCI19.6778

Disease-specific tau filaments assemble via polymorphic intermediates

article Full Text OpenAlex 181 FWCI26.7026

The interface of condensates of the hnRNPA1 low-complexity domain promotes formation of amyloid fibrils

article Full Text OpenAlex 172 FWCI25.2438