专题:TGF-β signaling in diseases

This cluster of papers explores the diverse aspects of the Transforming Growth Factor Beta (TGF-ß) signaling pathway, including its role in Smad-dependent and Smad-independent pathways, tumor suppression, cancer progression, bone morphogenetic protein (BMP) signaling, immune response modulation, cell differentiation, metastasis, regulation of epithelial-mesenchymal transition (EMT), and angiogenesis. It also discusses the development and use of TGF-ß inhibitors for potential therapeutic interventions.
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Notch signaling governs colorectal cancer metastasis via transcriptional control of TGF-β effectors SMAD2/SMAD3

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Characteristics of p53 and Smad4 immunohistochemistry in pancreatic ductal adenocarcinoma and validation by next-generation sequencing.

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Association of growth differentiation factor-15 with muscle wasting and anemia in chronic kidney disease

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Smad6-mediated inhibition of BMP/TGF-β signaling disrupts midbrain growth in chick embryos

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Circulating Follistatin-like 1 associates with inflammation, cognitive decline, and amyloid pathology in Alzheimer’s disease and promotes Aβ-induced neuronal ferroptosis via PI3K/Akt signaling

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Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma

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Rationale for multi-epitope TGFβ vaccination in pancreatic cancer: evidence from immunologic and clinical correlates

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Circulating plasma follistatin follows a 24-hour rhythm in healthy young males

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Sotatercept improves small airway disease and hyperinflation in patients with pulmonary hypertension

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Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications

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