专题：TGF-β signaling in diseases

This cluster of papers explores the diverse aspects of the Transforming Growth Factor Beta (TGF-ß) signaling pathway, including its role in Smad-dependent and Smad-independent pathways, tumor suppression, cancer progression, bone morphogenetic protein (BMP) signaling, immune response modulation, cell differentiation, metastasis, regulation of epithelial-mesenchymal transition (EMT), and angiogenesis. It also discusses the development and use of TGF-ß inhibitors for potential therapeutic interventions.
最新文献
Inhibitory probes for spatiotemporal analysis of Gαs protein signaling

article Full Text OpenAlex

Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome

article Full Text OpenAlex

ZBTB20 coordinates the proliferation-differentiation switch of incisor epithelial progenitor cells

article Full Text OpenAlex

SEAP reporter assay for assessing NF-κB inhibition by TGF-β1/PD-L1 fusion protein v1

article Full Text OpenAlex

Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis

article Full Text OpenAlex

TGF-β/BMP signaling in skeletal biology: molecular mechanisms, regulatory networks, and therapeutic implications in development, regeneration, and disease

article Full Text OpenAlex

SMAD7 regulates the canonical Wnt signaling through TGF-β cascade crosstalk and SMAD7/β-CATENIN transcription factor complex formation during tooth regeneration

article Full Text OpenAlex

Clinical Applications of Ligand Traps Targeting Activin Type II Receptors

article Full Text OpenAlex

Xijiaqi Formula attenuates myocardial infarction-induced chronic heart failure by inhibiting TGF-β1/Smads-mediated fibroblast activation

article Full Text OpenAlex

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

article Full Text OpenAlex

近5年高被引文献
Targeting TGF-β signal transduction for fibrosis and cancer therapy

review Full Text OpenAlex 925 FWCI75.207

TGF-β signaling in health, disease and therapeutics

review Full Text OpenAlex 798 FWCI192.1307

TGF-β signaling in health and disease

review Full Text OpenAlex 685 FWCI107.9619

The roles and regulatory mechanisms of TGF-β and BMP signaling in bone and cartilage development, homeostasis and disease

article Full Text OpenAlex 322 FWCI77.6237

Intricacies of TGF-β signaling in Treg and Th17 cell biology

review Full Text OpenAlex 260 FWCI40.6224

TGF-β in developmental and fibrogenic EMTs

review Full Text OpenAlex 259 FWCI26.1599

Whole Aspect of Runx2 Functions in Skeletal Development

review Full Text OpenAlex 205 FWCI16.7554

Transforming Growth Factor-Beta (TGF-β) Signaling in Cancer-A Betrayal Within

review Full Text OpenAlex 205 FWCI16.7416

Epithelial cells activate fibroblasts to promote esophageal cancer development

article Full Text OpenAlex 175 FWCI27.967

Smad3 Signatures in Renal Inflammation and Fibrosis

review Full Text OpenAlex 165 FWCI22.4702