专题：Cytokine Signaling Pathways and Interactions

This cluster of papers focuses on the role of STAT3 in cancer inflammation and immunity, with a particular emphasis on its involvement in cytokine signaling, regulation of the JAK/STAT pathway, modulation of the immune response, and its impact on the tumor microenvironment. The cluster also explores the interplay between STAT3, IL-6, and SOCS proteins in transcriptional control, inflammation, and cancer progression.
最新文献
“Cytokine-Mediated tumor sensitization: mechanistic frameworks and therapeutic opportunities in cancer Immunotherapy”

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PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling

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Pharmacological targeting of the JAK–STAT pathway: new concepts and emerging indications

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Opportunities and challenges of targeting cGAS–STING in cancer

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Targeting STING to generate therapeutic anti-tumor immunity

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Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity

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Interferon signaling pathways in health and disease

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Advances in TCDD-inducible poly(ADP-ribose) polymerase (TiPARP/PARP7) research: From molecular mechanisms to therapeutic applications

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Impact of rare JAK/STAT germline mutations on vaccination-induced innate immune responses in a Tyrolian population

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Endothelial ADAR1 Deficit Induces the NOCT-IRF7 Axis in Pulmonary Hypertension

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近5年高被引文献
NF-κB in biology and targeted therapy: new insights and translational implications

article Full Text OpenAlex 1452 FWCI424.9329

Osteoarthritis: pathogenic signaling pathways and therapeutic targets

review Full Text OpenAlex 966 FWCI246.6793

The JAK-STAT pathway at 30: Much learned, much more to do

review Full Text OpenAlex 610 FWCI59.0226

Advances in the pathogenesis of psoriasis: from keratinocyte perspective

review Full Text OpenAlex 554 FWCI44.1229

Multiple sclerosis progression: time for a new mechanism-driven framework

review Full Text OpenAlex 546 FWCI72.6371

Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer

review Full Text OpenAlex 534 FWCI124.0812

Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach

review Full Text OpenAlex 448 FWCI44.7857

Targeting IL-6 trans-signalling: past, present and future prospects

review Full Text OpenAlex 431 FWCI100.4506

Obesity, Inflammation, and Immune System in Osteoarthritis

review Full Text OpenAlex 414 FWCI59.866

The role of IL-6/JAK2/STAT3 signaling pathway in cancers

review Full Text OpenAlex 402 FWCI39.0305