This cluster of papers focuses on the applications of platelet-rich plasma (PRP) in regenerative medicine, particularly in the fields of orthopedic surgery and periodontal regeneration. The papers explore the use of PRP as a source of growth factors for tissue regeneration, its effectiveness in treating musculoskeletal injuries and osteoarthritis, and its potential as a biological agent for promoting healing and regeneration. Additionally, the cluster discusses the optimization and quantification of cytokines and growth factors in PRP for regenerative medicine.