专题：NF-κB Signaling Pathways

This cluster of papers explores the role of NF-?B signaling in inflammation, immunity, and cancer. It covers various aspects such as the regulation of NF-?B activity, the link between NF-?B and inflammatory diseases, the impact of NF-?B on cancer development and progression, and the crosstalk with other signaling pathways. The papers also discuss potential therapeutic strategies targeting the NF-?B pathway.
最新文献
NF-κB Signaling Pathway: A Central Hub in the Pathogenesis and Therapeutic Targeting of Immunological Diseases

article Full Text OpenAlex

Ku70: molecular mechanisms and pathogenesis in inflammation and cancer

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Multidimensional Regulatory Mechanisms and Targeted Therapeutic Strategies for Inhibited Keratinocyte Proliferation in Diabetic Wounds

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Alkalization of the intracellular pH reprograms TNF-α signaling from inflammatory NF-κB activation to tumoricidal RIP kinase-dependent necroptosis in cancer cells

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Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression

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4-octyl itaconate inhibits cytokine-mediated inflammation via alkylation of TYK2 and JAK1

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NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells

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In silico evaluation of itaconic acid as a potential inhibitor of KRAS and PPARG proteins in lung cancer

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Caspase-8-mediated CYLD cleavage boosts LPS-induced endotoxic shock

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USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses

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近5年高被引文献
NF-κB in biology and targeted therapy: new insights and translational implications

article Full Text OpenAlex 1593 FWCI429.3151

NF-κB: blending metabolism, immunity, and inflammation

review Full Text OpenAlex 495 FWCI43.0574

BCL-2 protein family: attractive targets for cancer therapy

review Full Text OpenAlex 475 FWCI36.5733

Apoptosis: A Comprehensive Overview of Signaling Pathways, Morphological Changes, and Physiological Significance and Therapeutic Implications

review Full Text OpenAlex 388 FWCI84.5485

Toll-like receptor 4 (TLR4): new insight immune and aging

review Full Text OpenAlex 356 FWCI56.5031

DNA damage and repair in age-related inflammation

review Full Text OpenAlex 349 FWCI25.2279

The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer’s Disease

review Full Text OpenAlex 338 FWCI37.9244

Design of target specific peptide inhibitors using generative deep learning and molecular dynamics simulations

article Full Text OpenAlex 268 FWCI83.3599

Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: Efficacy and safety results from the 52-week, randomized, double-blinded, phase 3 Program fOr Evaluation of TYK2 inhibitor psoriasis second trial

article Full Text OpenAlex 267 FWCI20.8808

Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice

article Full Text OpenAlex 261 FWCI57.8243