This cluster of papers explores the impact of HIV infection, antiretroviral therapy, inflammation, metabolic abnormalities, and aging on cardiovascular health. It covers a wide range of topics including myocardial infarction, lipodystrophy, bone mineral density, insulin resistance, and the association between HIV infection and various cardiovascular diseases. The research also delves into the effects of specific antiretroviral drugs on cardiovascular risk factors and provides insights into the management of metabolic complications associated with HIV-1 infection.