专题：Congenital heart defects research

This cluster of papers explores the molecular mechanisms underlying cardiac development, regeneration, and congenital heart defects. It covers topics such as cardiomyocyte renewal, cardiac progenitor populations, endothelial cell-lineage analysis, neural crest contributions, epicardial progenitors, Wnt signaling, T-box genes, and the potential of microRNA therapy for cardiac regeneration.
最新文献
Single nucleus RNA sequencing and functional in vivo studies reveal TCF21 as a protective regulator in cardiac fibrosis

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An innovative in vitro model for studying the biology of cardiac fibroblasts originating from the epicardium

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Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles

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Shared splicing dysregulation in heart failure associated with dilated and ischaemic cardiomyopathy and spatial specificity across cardiac regions

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GFAP + FOXF2 + ependymal cells promote blood–brain barrier repair via DLL4–NOTCH signaling after neural injury

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Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties

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Hierarchical TBX6-FOXC Regulatory Logic Governs Human Trunk Mesoderm Diversification

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RHOT Proteins Link Mitochondrial Motility to Cardiomyocyte Sarcomere Maturation

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Syndromic Inborn Errors of Immunity in TREC-Newborn Screening: 5-year Experience from the German Screening Program

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Reductions in myocardial interstitial fibrosis are dissociated from LV chamber stiffness in swine with repetitive pressure overload

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近5年高被引文献
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

review Full Text OpenAlex 657 FWCI110.8784

Rare coding variation provides insight into the genetic architecture and phenotypic context of autism

review Full Text OpenAlex 591 FWCI70.0503

Diagnosis and Evaluation of Hypertrophic Cardiomyopathy

review Full Text OpenAlex 552 FWCI81.5598

Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction

article Full Text OpenAlex 455 FWCI63.7031

How vascular smooth muscle cell phenotype switching contributes to vascular disease

review Full Text OpenAlex 344 FWCI26.4712

Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction

article Full Text OpenAlex 341 FWCI73.4274

Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration

article Full Text OpenAlex 288 FWCI24.8415

Embryo model completes gastrulation to neurulation and organogenesis

article Full Text OpenAlex 250 FWCI20.743

Inhibition of fatty acid oxidation enables heart regeneration in adult mice

article Full Text OpenAlex 230 FWCI71.3827

Genomic Diagnosis of Rare Pediatric Disease in the United Kingdom and Ireland

article Full Text OpenAlex 213 FWCI65.0662