专题：Congenital heart defects research

This cluster of papers explores the molecular mechanisms underlying cardiac development, regeneration, and congenital heart defects. It covers topics such as cardiomyocyte renewal, cardiac progenitor populations, endothelial cell-lineage analysis, neural crest contributions, epicardial progenitors, Wnt signaling, T-box genes, and the potential of microRNA therapy for cardiac regeneration.
最新文献
Altered brain structure in an ATRX-deficient mouse model of autism spectrum disorder

preprint Full Text OpenAlex

M2c Macrophages Mediate YAP1 to Promote Vascularized Bone Regeneration in Distraction Osteogenesis

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Comment on Schwarz et al. “EFNB3 Frameshift Variant in Weimaraner Dogs with a Condition Resembling a Congenital Mirror Movement Disorder”

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Repurposing nicardipine leads to improved development in a young patient with Pitt–Hopkins syndrome

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Essential regulation of heparan sulfate proteoglycan signalling controls cell behaviour to support cardiac development

preprint Full Text OpenAlex

Speech and Language Disorders Associated With 7q31 Deletions Implicating FOXP2

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Forebrain assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects

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The Ultrasound and Genetic Characteristics of Fetuses With Laterality Defects—A Prenatal Cohort in Asian Population

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Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development

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Coordinated expression of BMP10/ALK1/endoglin—proteins that drive embryonic cardiac and vascular morphogenesis—in patients with heart failure: The EMPEROR Program

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近5年高被引文献
ACMG SF v3.0 list for reporting of secondary findings in clinical exome and genome sequencing: a policy statement of the American College of Medical Genetics and Genomics (ACMG)

article Full Text OpenAlex 481 FWCI62.936

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants

review Full Text OpenAlex 468 FWCI23.794

Exome and genome sequencing for pediatric patients with congenital anomalies or intellectual disability: an evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG)

article Full Text OpenAlex 446 FWCI50.349

Rare coding variation provides insight into the genetic architecture and phenotypic context of autism

review Full Text OpenAlex 407 FWCI18.573

Diagnosis and Evaluation of Hypertrophic Cardiomyopathy

review Full Text OpenAlex 401 FWCI25.709

Cardioids reveal self-organizing principles of human cardiogenesis

article Full Text OpenAlex 390 FWCI25.607

Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease

article Full Text OpenAlex 339 FWCI20.937

Human heart-forming organoids recapitulate early heart and foregut development

article Full Text OpenAlex 325 FWCI22.183

Polygenic basis and biomedical consequences of telomere length variation

article Full Text OpenAlex 286 FWCI33.781

Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis

article Full Text OpenAlex 271 FWCI17.824