专题：Histone Deacetylase Inhibitors Research

This cluster of papers explores the role of histone deacetylases (HDACs) in regulating cellular functions, gene expression, and epigenetic modifications. It covers the use of HDAC inhibitors in cancer therapy, their impact on neurodegenerative disorders, and their involvement in protein complexes and enzymatic activity.
最新文献
Notch signaling pathway in cancer: from mechanistic insights to targeted therapies

review Full Text OpenAlex

Effects of quercetin on the DNA methylation pattern in tumor therapy: an updated review

article Full Text OpenAlex

Development of Hydrazide-Based HDAC6 Selective Inhibitors for Treating NLRP3 Inflammasome-Related Diseases

article Full Text OpenAlex

Lead optimization of a CHI3L1 inhibitor for Glioblastoma: Enhanced target engagement, pharmacokinetics, and efficacy in 3D spheroid models

article Full Text OpenAlex

Trends in Neosubstrate Degradation by Cereblon-Based Molecular Glues and the Development of Novel Multiparameter Optimization Scores

article Full Text OpenAlex

Emerging Neuroprotective Strategies: Unraveling the Potential of HDAC Inhibitors in Traumatic Brain Injury Management

review Full Text OpenAlex

Determinants of lenalidomide response with or without erythropoiesis-stimulating agents in myelodysplastic syndromes: the HOVON89 trial

article Full Text OpenAlex

Involvement of the ubiquitin-proteasome system in the regulation of the tumor microenvironment and progression

review Full Text OpenAlex

CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK

article Full Text OpenAlex

Exercise alleviates cisplatin-induced toxicity in the hippocampus of mice by inhibiting neuroinflammation and improving synaptic plasticity

article Full Text OpenAlex

近5年高被引文献
Modulation of cellular processes by histone and non-histone protein acetylation

review Full Text OpenAlex 758 FWCI95.13245912

Metabolic reprogramming and epigenetic modifications on the path to cancer

review Full Text OpenAlex 653 FWCI43.40193013

Natural Products in Cancer Therapy: Past, Present and Future

review Full Text OpenAlex 571 FWCI40.96361944

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases

article Full Text OpenAlex 514 FWCI64.36516962

MYC as a target for cancer treatment

review Full Text OpenAlex 477 FWCI37.9401142

Meta-hallmarks of aging and cancer

review Full Text OpenAlex 429 FWCI134.17144653

Epigenetic mechanisms in breast cancer therapy and resistance

review Full Text OpenAlex 427 FWCI31.89310371

Therapeutic targeting of “undruggable” MYC

review Full Text OpenAlex 425 FWCI31.99063614

Ivosidenib and Azacitidine in IDH1 -Mutated Acute Myeloid Leukemia

article Full Text OpenAlex 420 FWCI94.31063547

Advances in acute myeloid leukemia

review Full Text OpenAlex 415 FWCI67.02186684