专题：Histone Deacetylase Inhibitors Research

This cluster of papers explores the role of histone deacetylases (HDACs) in regulating cellular functions, gene expression, and epigenetic modifications. It covers the use of HDAC inhibitors in cancer therapy, their impact on neurodegenerative disorders, and their involvement in protein complexes and enzymatic activity.
最新文献
Discovery of Potent HDAC6-Selective Inhibitors Based on Artemisinin: Design, Synthesis, and Antitumor Evaluation

article Full Text OpenAlex

Identification of an allosteric site on the E3 ligase adapter cereblon

article Full Text OpenAlex

Environmental epigenetics: new horizons in redefining biological and health outcomes

article Full Text OpenAlex

Therapeutic horizons in the development of PROTAC-based EZH2 inhibitors: recent achievements, comparative analysis, and future perspectives

article Full Text OpenAlex

Targetome-guided combination drug discovery as next-generation therapeutics

article Full Text OpenAlex

Navigating drug discovery with <i>Targetome</i>

article Full Text OpenAlex

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

article Full Text OpenAlex

Spatial metabolic and protein profiles reveal astragaloside IV attenuates diabetic nephropathy by inhibiting ST13 acetylation at lysine 14 to restore amino acid metabolism dysregulation

article Full Text OpenAlex

Histone acetylation homeodynamics navigates cell survival and apoptosis

article Full Text OpenAlex

HDAC5 deficiency induces intrinsic resistance to KRAS inhibition by disrupting c-Myc acetylation-ubiquitination homeostasis

article Full Text OpenAlex

近5年高被引文献
Modulation of cellular processes by histone and non-histone protein acetylation

review Full Text OpenAlex 837 FWCI69.135

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases

article Full Text OpenAlex 609 FWCI47.8827

Meta-hallmarks of aging and cancer

review Full Text OpenAlex 485 FWCI90.2465

Ivosidenib and Azacitidine in IDH1 -Mutated Acute Myeloid Leukemia

article Full Text OpenAlex 458 FWCI69.765

Myeloid-derived suppressor cells: an emerging target for anticancer immunotherapy

review Full Text OpenAlex 441 FWCI35.9614

The menin inhibitor revumenib in KMT2A-rearranged or NPM1-mutant leukaemia

article Full Text OpenAlex 431 FWCI126.8925

Rational combinations of targeted cancer therapies: background, advances and challenges

review Full Text OpenAlex 429 FWCI33.4289

Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study

review Full Text OpenAlex 384 FWCI60.6211

Signaling pathways in Parkinson’s disease: molecular mechanisms and therapeutic interventions

review Full Text OpenAlex 373 FWCI56.8523

Demethylzeylasteral targets lactate by inhibiting histone lactylation to suppress the tumorigenicity of liver cancer stem cells

article Full Text OpenAlex 348 FWCI28.5388