This cluster of papers focuses on the management, pathophysiology, and risk factors associated with intracerebral hemorrhage, including cerebral amyloid angiopathy, hematoma growth, neuroinflammation, microbleeds, anticoagulant therapy, perihematomal edema, and molecular mechanisms. It also discusses guidelines for the management of spontaneous intracerebral hemorrhage in adults and the use of recombinant factor VIIa for acute intracerebral hemorrhage.