专题：Cancer therapeutics and mechanisms

This cluster of papers focuses on the structure, function, inhibition, and genetic variants of DNA topoisomerases, particularly their roles in chemotherapy, the mechanism of action of specific inhibitors such as irinotecan and quinolones, and their impact on genomic stability. The papers also explore the potential use of genetic variants in predicting drug toxicity and treatment outcomes.
最新文献
Design and Multi-Level Biological Evaluation of Naphthyridine-Based Derivatives as Topoisomerase I/II-Targeted Anticancer Agents with Anti-Fowlpox Virus Activity Supported by In Silico Analysis

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Unveiling the hidden risks of nanomedicine-based drug delivery: a comparative evaluation of drug safety profiles of liposomal irinotecan and conventional irinotecan

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Deciphering mechanistic and therapeutic insight of pyrazolopyrimidines into MRSA suppression: comprehensive in vitro and in vivo study

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Pharmacogenomic and in silico identification of isoform-selective AKT inhibitors from Pithecellobium dulce for precision cancer therapy

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Discovery of novel structural imidazolylvinylquinolones exerting excellent broad-spectrum antibacterial efficacy with multitargeting potential

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Unique Bidentate Chelators of Functionalized HeterocyclicFluoroquinolones with Dual Anti-Inflammatory and SelectiveCytotoxic Effects via a C7-C8 Ethylene Diamine Bridge

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Neuroblastoma in Childhood: Biological Insights, Risk Stratification, and Advances in Multimodal Therapy

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Cytotoxicity of a new condensed benzimidazoledione derivative against tumor and normal cell lines

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Therapeutic Strategies to Overcome Payload Resistance of Trastuzumab Deruxtecan in HER2 ‐Positive Cancers

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Current scenario of indole-azole hybrids with anticancer potential: part II. Imidazole, oxadiazole, oxazole, and isoxazole hybrids

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近5年高被引文献
Molecular mechanisms of antibiotic resistance revisited

review Full Text OpenAlex 1233 FWCI78.096

Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches

review Full Text OpenAlex 522 FWCI50.0519

Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management

review Full Text OpenAlex 465 FWCI64.6986

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

review Full Text OpenAlex 442 FWCI72.0725

Rational combinations of targeted cancer therapies: background, advances and challenges

review Full Text OpenAlex 442 FWCI33.3667

Human topoisomerases and their roles in genome stability and organization

review Full Text OpenAlex 436 FWCI34.458

Chemotherapy Side-Effects: Not All DNA Damage Is Equal

review Full Text OpenAlex 423 FWCI152.0251

Therapeutic strategies for EGFR-mutated non-small cell lung cancer patients with osimertinib resistance

review Full Text OpenAlex 357 FWCI48.3839

Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions

review Full Text OpenAlex 333 FWCI74.55

Cisplatin in cancer treatment

review Full Text OpenAlex 326 FWCI42.2029