专题：Cancer therapeutics and mechanisms

This cluster of papers focuses on the structure, function, inhibition, and genetic variants of DNA topoisomerases, particularly their roles in chemotherapy, the mechanism of action of specific inhibitors such as irinotecan and quinolones, and their impact on genomic stability. The papers also explore the potential use of genetic variants in predicting drug toxicity and treatment outcomes.
最新文献
A real-world analysis of FDA Adverse Event Reporting System (FAERS) events for liposomal nanoparticle-formulated and conventional anticancer irinotecan

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Deciphering mechanistic and therapeutic insight of pyrazolopyrimidines into MRSA suppression: comprehensive in vitro and in vivo study

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Etoposide dosing challenges in a testicular cancer patient with hepatic impairment and drug-drug interactions–a case report

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Discovery of novel structural imidazolylvinylquinolones exerting excellent broad-spectrum antibacterial efficacy with multitargeting potential

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Unique Bidentate Chelators of Functionalized HeterocyclicFluoroquinolones with Dual Anti-Inflammatory and SelectiveCytotoxic Effects via a C7-C8 Ethylene Diamine Bridge

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Design, Synthesis, and In Vitro and In Silico Anticancer Profiling of Spirooxindole–Tetrahydrocarbazoles

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Enzyme–DNA Interactions Affect the Catalytic Inhibition of Mycobacterial Gyrases by Antibacterial Drugs

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Targeted CRISPR knockout screening identifies known and novel chemogenomic interactions between DNA damaging agents and DNA repair genes

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Cisplatin as a Xenobiotic Agent: Molecular Mechanisms of Actions and Clinical Applications in Oncology

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Computational identification of carotol as a potent inhibitor of PDC-3 and NDM-1 β-lactamases in Pseudomonas aeruginosa

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近5年高被引文献
Molecular mechanisms of antibiotic resistance revisited

review Full Text OpenAlex 1160 FWCI77.7019

Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches

review Full Text OpenAlex 505 FWCI50.227

Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management

review Full Text OpenAlex 454 FWCI65.0514

Rational combinations of targeted cancer therapies: background, advances and challenges

review Full Text OpenAlex 429 FWCI33.4289

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

review Full Text OpenAlex 429 FWCI71.144

Human topoisomerases and their roles in genome stability and organization

review Full Text OpenAlex 425 FWCI34.4374

Effect of First-Line Serplulimab vs Placebo Added to Chemotherapy on Survival in Patients With Extensive-Stage Small Cell Lung Cancer

article Full Text OpenAlex 422 FWCI41.8558

Chemotherapy Side-Effects: Not All DNA Damage Is Equal

review Full Text OpenAlex 414 FWCI147.5287

Amivantamab plus chemotherapy with and without lazertinib in EGFR-mutant advanced NSCLC after disease progression on osimertinib: primary results from the phase III MARIPOSA-2 study

article Full Text OpenAlex 355 FWCI92.9934

Therapeutic strategies for EGFR-mutated non-small cell lung cancer patients with osimertinib resistance

review Full Text OpenAlex 341 FWCI48.3326