专题：Cancer therapeutics and mechanisms

This cluster of papers focuses on the structure, function, inhibition, and genetic variants of DNA topoisomerases, particularly their roles in chemotherapy, the mechanism of action of specific inhibitors such as irinotecan and quinolones, and their impact on genomic stability. The papers also explore the potential use of genetic variants in predicting drug toxicity and treatment outcomes.
最新文献
Activities of the Novel Bacterial Topoisomerase Inhibitor OSUAB-0284 against the Biothreat Pathogen Bacillus anthracis and Its Type II Topoisomerases

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Multiselective RAS(ON) inhibition targets oncogenic RAS and overcomes RAS-mediated resistance to FLT3i and BCL2i in AML

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Citrinin and cisplatin synergistically induce apoptosis in SKOV3 ovarian cancer cells via redox imbalance and mitochondrial dysfunction

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Integrated transcriptomic, metabolomic, and molecular docking analysis reveals the inhibitory mechanism of plumbagin against Penicillium expansum

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GEOM-drugs revisited: toward more chemically accurate benchmarks for 3D molecule generation

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Clinically approved immunotoxins targeting hematological cancers: “the best of both worlds”

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Accelerated In Silico Discovery of SGR-1505 : A Potent MALT1 Allosteric Inhibitor for the Treatment of Mature B-Cell Malignancies

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Identification of potent epidermal growth factor receptor (EGFR) inhibitors as potential lung cancer medications via virtual screening of 1,2,3-triazole containing pyridineamide derivatives

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Peiminine Alleviates Breast Carcinoma via Reprogramming the PI3K/Akt/mTOR Pathway in vitro and in vivo

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573. CD388, a Novel Drug-Fc Conjugate (DFC), Demonstrates Prophylactic Activity in an Influenza Human Challenge Model

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近5年高被引文献
Molecular mechanisms of antibiotic resistance revisited

review Full Text OpenAlex 1087 FWCI111.48124124

Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches

review Full Text OpenAlex 482 FWCI71.20512428

Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management

review Full Text OpenAlex 429 FWCI87.69655469

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

review Full Text OpenAlex 408 FWCI82.73468843

Human topoisomerases and their roles in genome stability and organization

review Full Text OpenAlex 404 FWCI48.6123174

Effect of First-Line Serplulimab vs Placebo Added to Chemotherapy on Survival in Patients With Extensive-Stage Small Cell Lung Cancer

article Full Text OpenAlex 399 FWCI59.13898397

Chemotherapy Side-Effects: Not All DNA Damage Is Equal

review Full Text OpenAlex 388 FWCI351.15254177

Rational combinations of targeted cancer therapies: background, advances and challenges

review Full Text OpenAlex 388 FWCI46.88934919

Therapeutic strategies for EGFR-mutated non-small cell lung cancer patients with osimertinib resistance

review Full Text OpenAlex 325 FWCI64.95282205

Amivantamab plus chemotherapy with and without lazertinib in EGFR-mutant advanced NSCLC after disease progression on osimertinib: primary results from the phase III MARIPOSA-2 study

article Full Text OpenAlex 323 FWCI108.63474535