专题：Cancer therapeutics and mechanisms

This cluster of papers focuses on the structure, function, inhibition, and genetic variants of DNA topoisomerases, particularly their roles in chemotherapy, the mechanism of action of specific inhibitors such as irinotecan and quinolones, and their impact on genomic stability. The papers also explore the potential use of genetic variants in predicting drug toxicity and treatment outcomes.
最新文献
First-line treatment of EGFR-mutated non-small cell lung cancer with brain metastases: a systematic review and meta-analysis

review Full Text OpenAlex

Borneol-modified docetaxel plus tetrandrine micelles for treatment of drug-resistant brain glioma

article Full Text OpenAlex

1-Deoxynojirimycin Attenuates High-Glucose-Induced Oxidative DNA Damage via Activating NRF2/OGG1 Signaling

article Full Text OpenAlex

Design, synthesis, antiproliferative, antituberculosis and in-silico analysis of New Schiff base derivatives of cyclohepta[b]thiophene

article Full Text OpenAlex

Design, synthesis, and antitumor activity evaluation of potent fourth-generation EGFR inhibitors for treatment of Osimertinib resistant non-small cell lung cancer (NSCLC)

article Full Text OpenAlex

Safety and efficacy of liposomal irinotecan as the second-line treatment for advanced pancreatic cancer: A systematic review and meta-analysis

review Full Text OpenAlex

Evaluation of Novel Spiro-pyrrolopyridazine Derivatives as Anticancer Compounds: In Vitro Selective Cytotoxicity, Induction of Apoptosis, EGFR Inhibitory Activity, and Molecular Docking Analysis

article Full Text OpenAlex

Shikonin reactivates TSGs GADD45B and PPP3CC to block NSCLC cell proliferation and migration through JNK/P38/MAPK signaling pathways

article Full Text OpenAlex

Sodium citrate buffer improves pazopanib solubility and absorption in gastric acid-suppressed rat model

article Full Text OpenAlex

A minimal PBPK model to accelerate preclinical development of drugs against tuberculosis

article Full Text OpenAlex

近5年高被引文献
Small-cell lung cancer

review Full Text OpenAlex 1345 FWCI104.93632508

Molecular mechanisms of antibiotic resistance revisited

review Full Text OpenAlex 1017 FWCI106.26208201

Updated Overall Survival and PD-L1 Subgroup Analysis of Patients With Extensive-Stage Small-Cell Lung Cancer Treated With Atezolizumab, Carboplatin, and Etoposide (IMpower133)

article Full Text OpenAlex 722 FWCI55.5606916

Overcoming therapy resistance in EGFR-mutant lung cancer

review Full Text OpenAlex 472 FWCI60.66752181

Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches

review Full Text OpenAlex 465 FWCI69.26858324

Clinical Acquired Resistance to KRASG12C Inhibition through a Novel KRAS Switch-II Pocket Mutation and Polyclonal Alterations Converging on RAS–MAPK Reactivation

article Full Text OpenAlex 446 FWCI35.01414138

Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management

review Full Text OpenAlex 420 FWCI85.85246826

Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group

article Full Text OpenAlex 403 FWCI40.84383277

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

review Full Text OpenAlex 391 FWCI79.67798812

Effect of First-Line Serplulimab vs Placebo Added to Chemotherapy on Survival in Patients With Extensive-Stage Small Cell Lung Cancer

article Full Text OpenAlex 387 FWCI57.35140763