专题：Hedgehog Signaling Pathway Studies

This cluster of papers focuses on the role of Hedgehog signaling in both animal development and cancer, particularly its involvement in tumorigenesis, stem cell renewal, and the progression of specific cancers such as pancreatic cancer and basal cell carcinoma. The papers also discuss the mechanisms of Hedgehog pathway inhibition and its potential as a therapeutic target for cancer treatment.
最新文献
Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway

article Full Text OpenAlex

Morphogen Gradients, Primary Cilia, and Centriolar Aging

article Full Text OpenAlex

Wnt signaling pathway: Therapeutic target of natural products for cancer therapy

review Full Text OpenAlex

Therapeutic targeting of FZD receptor proteins with biologics in cancer

review Full Text OpenAlex

Identification of Wnt‐regulated genes that are repressed by, or independent of, β‐catenin

article Full Text OpenAlex

The diverse roles of Hox proteins in the regulation of the cell cycle and their therapeutic value in cancer treatment

review Full Text OpenAlex

A dual role for GLI3 signaling in neural crest development

article Full Text OpenAlex

Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma

article Full Text OpenAlex

Comprehensive Insights Into Basal Cell Carcinoma: Causes, Presentation, Prevention, and Modern Therapeutic Approaches

article Full Text OpenAlex

Smoothened-mediated signaling contributes to immune and non-immune functions of microglia

article Full Text OpenAlex

近5年高被引文献
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

article Full Text OpenAlex 2508 FWCI134.2515

The Wnt Pathway: From Signaling Mechanisms to Synthetic Modulators

review Full Text OpenAlex 488 FWCI8.4611

Wnt signaling pathway: A comprehensive review

article Full Text OpenAlex 348 FWCI19.7329

European consensus-based interdisciplinary guideline for diagnosis and treatment of basal cell carcinoma—update 2023

article Full Text OpenAlex 317 FWCI52.4814

Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances

article Full Text OpenAlex 289 FWCI72.0015

Hedgehog signaling in tissue homeostasis, cancers and targeted therapies

article Full Text OpenAlex 251 FWCI18.6184

Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

article Full Text OpenAlex 221 FWCI16.4922

Cellular and molecular mechanisms of Hedgehog signalling

review Full Text OpenAlex 196 FWCI4.8911

WNT signaling and cancer stemness

article Full Text OpenAlex 180 FWCI9.2472

Emerging mechanistic understanding of cilia function in cellular signalling

review Full Text OpenAlex 166 FWCI15.4911