专题：Hippo pathway signaling and YAP/TAZ

This cluster of papers explores the role of the Hippo signaling pathway, particularly the involvement of YAP/TAZ, in mechanotransduction, cell proliferation, tissue growth control, organ size control, and its implications in cancer and stem cell regulation.
最新文献
Distinct molecular pathways regulated by activated AKT and YAP signaling during intrahepatic cholangiocarcinoma progression

article Full Text OpenAlex

Discovery of Clinical Candidate IAG933, a Potent YAP-TEAD PPI Disrupter

article Full Text OpenAlex

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

article Full Text OpenAlex

Long non-coding RNA MEG3 acts as a tumor inhibitor in human cancer

article Full Text OpenAlex

Allosteric and energetic remodeling of a PDZ domain by protein domain extensions

article Full Text OpenAlex

Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis

article Full Text OpenAlex

Engineered intestinal crypt geometry uncovers YAP1-dependent fetal-to-adult transition

article Full Text OpenAlex

Discovery and In Vivo Evaluation of Aryl Ether YAP1/TEAD Inhibitors for the Treatment of Hippo-Driven Malignancies

article Full Text OpenAlex

The Multi-Faceted Landscape of TEAD Inhibition: a 2017–2025 Patent and Literature Review

article Full Text OpenAlex

Nuclear PD-L1 regulates YAP-driven transcription via the PGE2-EP4-YAP-importin α3 axis in solid tumors

article Full Text OpenAlex

近5年高被引文献
The Hippo signalling pathway and its implications in human health and diseases

review Full Text OpenAlex 669 FWCI66.7584

Mechanical regulation of bone remodeling

review Full Text OpenAlex 530 FWCI53.4767

Tissue geometry drives deterministic organoid patterning

article Full Text OpenAlex 478 FWCI46.9267

Extracellular fluid viscosity enhances cell migration and cancer dissemination

article Full Text OpenAlex 393 FWCI42.2904

Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets

review Full Text OpenAlex 316 FWCI84.5209

YAP/TAZ activity in stromal cells prevents ageing by controlling cGAS–STING

article Full Text OpenAlex 310 FWCI33.6671

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer

review Full Text OpenAlex 309 FWCI32.7353

Cancer cell plasticity during tumor progression, metastasis and response to therapy

review Full Text OpenAlex 301 FWCI66.2941

Towards targeting of shared mechanisms of cancer metastasis and therapy resistance

review Full Text OpenAlex 280 FWCI26.8469

N6-Methyladenosine–Mediated Up-Regulation of FZD10 Regulates Liver Cancer Stem Cells’ Properties and Lenvatinib Resistance Through WNT/β-Catenin and Hippo Signaling Pathways

article Full Text OpenAlex 270 FWCI54.3539