This cluster of papers focuses on the management, genetic aspects, and complications of hyperbilirubinemia in newborn infants. It covers topics such as glucose-6-phosphate dehydrogenase deficiency, neonatal jaundice, bilirubin metabolism, kernicterus, phototherapy, UGT1A1 gene mutations, neurotoxicity, bilirubin measurement methods, genetic variants associated with hyperbilirubinemia, and the importance of newborn screening programs.