This cluster of papers explores the pathophysiology, clinical features, and outcomes of stress-induced cardiomyopathy, also known as Takotsubo Syndrome. It delves into the role of neurohumoral features, catecholamine cardiotoxicity, and the brain-heart axis in the development of this condition. Additionally, it investigates the association with neurogenic pulmonary edema, cardiac troponin elevation, myocardial stunning, and its occurrence after subarachnoid hemorrhage.