专题：Protein Tyrosine Phosphatases

This cluster of papers explores the role of protein tyrosine phosphatases, particularly PTPN11 and SHP2, in various human health and disease conditions such as Noonan syndrome, cancer, insulin sensitivity, and MAP kinase signaling. It also delves into the redox regulation of protein tyrosine phosphatases and their implications in cell signaling pathways.
最新文献
Biochemical and structural studies of the midnolin Catch domain bound with both wild-type and mutant IRF4 peptides reveal the molecular basis for its broad substrate specificity

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Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia

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Targeting PTPN13 with 11-amino-acid peptides of C-terminal APC prevents immune evasion of colorectal cancer

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Genetic susceptibility to rheumatoid arthritis: a meta-analysis of interleukin-10 and protein tyrosine phosphatase non-receptor type 22 gene variants

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Insights from a novel monogenic autoinflammatory disease: overview of a multicentric European cohort of 38 patients with COPA syndrome

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Glycosaminoglycans Targeted by Colchicine in MCF-7 Cells

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Bioactivity-based molecular networking-guided identification of methyl rosmarinate from Orthosiphon aristatus as a PTP1B inhibitor that improves insulin sensitivity in diabetic mice

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4-Methylumbelliferone, an hyaluronan synthase inhibitor, prevents the development of oncological, inflammatory, degenerative and autoimmune disorders

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Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation‐Associated Microglial Response (Adv. Sci. 15/2025)

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High de novo mutation rate in Iranian NF2-related schwannomatosis patients with a report of a novel NF2 mutation

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近5年高被引文献
The RASopathies: from pathogenetics to therapeutics

review Full Text OpenAlex 158 FWCI19.56799612

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

article Full Text OpenAlex 141 FWCI26.17952748

KRASG12C-independent feedback activation of wild-type RAS constrains KRASG12C inhibitor efficacy

article Full Text OpenAlex 132 FWCI16.1220597

Targeting galectin-3 in inflammatory and fibrotic diseases

review Full Text OpenAlex 130 FWCI25.21179283

Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C

article Full Text OpenAlex 125 FWCI15.13750643

Human Protein Tyrosine Phosphatase 1B (PTP1B): From Structure to Clinical Inhibitor Perspectives

review Full Text OpenAlex 115 FWCI14.02988401

Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice

article Full Text OpenAlex 113 FWCI18.38183054

Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders

review Full Text OpenAlex 104 FWCI19.68106321

A comprehensive review of SHP2 and its role in cancer

review Full Text OpenAlex 101 FWCI11.93770832

TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation

article Full Text OpenAlex 100 FWCI48.02472251