专题：Quinazolinone synthesis and applications

This cluster of papers focuses on the chemistry, synthesis, and pharmacological properties of quinazoline compounds, including indirubin derivatives. It covers a wide range of topics such as inhibition of protein kinases, antitumor activity, antimicrobial effects, and anti-inflammatory properties.
最新文献
Design, synthesis and biological evaluation of triazolo[1,5-a]pyrimidine derivatives as new antiproliferative agents with multikinase inhibitory activity

article Full Text OpenAlex

Synthesis, evaluation of in vitro cytotoxic activity, and in silico studies of some 3-methylenamino-4(3H)-quinazolone derivatives

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8-Nitrotryptanthrin inhibits colorectal cancer progression via TGF-β/SMAD and PI3K/AKT/mTOR pathways

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Ruthenium(ii)-catalyzed C-2 alkenylation of indole with olefins via a quinazolin-4(3H)-one directing group: a platform for selective fluorescent anion sensors

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ABLIM1 promotes the proliferation, migration and invasion of osteosarcoma through DCC mediated activation of PI3K/AKT signaling pathway

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PTEN-induced kinase 1 (PINK1) Mediating Mitophagy and its Correlation to Subclinical Atherosclerosis in Patients with Psoriatic Arthritis

preprint Full Text OpenAlex

Synthesis and Anticancer Evaluation of Some Glycine Conjugated Hybrid Compounds Containing Coumarin, Thiophene and Quinazoline Moieties

preprint Full Text OpenAlex

2H-1,4-Benzoxazin-3(4H)-one linked 1,2,3-triazole derivatives and their study on inducing DNA damage in tumor cells

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Review for "Synthesis, evaluation of <i>in vitro</i> cytotoxic activity, and <i>in silico</i> studies of some 3-methylenamino-4(3<i>H</i>)-quinazolone derivatives"

peer-review Full Text OpenAlex

Decision letter for "Synthesis, evaluation of <i>in vitro</i> cytotoxic activity, and <i>in silico</i> studies of some 3-methylenamino-4(3<i>H</i>)-quinazolone derivatives"

peer-review Full Text OpenAlex

近5年高被引文献
Trends in kinase drug discovery: targets, indications and inhibitor design

review Full Text OpenAlex 625 FWCI26.113

ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer

review Full Text OpenAlex 268 FWCI5.651

Late-stage diversification of indole skeletons through nitrogen atom insertion

article Full Text OpenAlex 236 FWCI25.862

Properties of FDA-approved small molecule protein kinase inhibitors: A 2022 update

review Full Text OpenAlex 192 FWCI4.022

Dihydroartemisinin: A Potential Natural Anticancer Drug

review Full Text OpenAlex 186 FWCI3.236

Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer

article Full Text OpenAlex 159 FWCI21.325

Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma

review Full Text OpenAlex 123 FWCI4.264

Caspase‐3: A primary target for natural and synthetic compounds for cancer therapy

review Full Text OpenAlex 122 FWCI3.25

Drug Resistance in Nontuberculous Mycobacteria: Mechanisms and Models

review Full Text OpenAlex 119 FWCI4.216

Unified Access to Pyrimidines and Quinazolines Enabled by N–N Cleaving Carbon Atom Insertion

article Full Text OpenAlex 119 FWCI12.931