专题：Quinazolinone synthesis and applications

This cluster of papers focuses on the chemistry, synthesis, and pharmacological properties of quinazoline compounds, including indirubin derivatives. It covers a wide range of topics such as inhibition of protein kinases, antitumor activity, antimicrobial effects, and anti-inflammatory properties.
最新文献
Visible-Light-Induced Chemodivergent Synthesis of Tetracyclic Quinazolinones and 3-Iminoisoindoliones via the Substrate Control Strategy

article Full Text OpenAlex

Design, synthesis and biological evaluation of 5H-[1,2,4]triazino[5,6-b]indole derivatives bearing a pyridinocycloalkyl moiety as iron chelators

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A facile ultrasonic synthesis approach to 3- H -quinazolinethione derivatives and their urease inhibition studies

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Photocatalytic synthesis of 2,4‐substituted quinazolines via a one‐pot, three‐component reaction under catalyst‐free conditions

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Evaluation of the Lipophilicity of Angularly Condensed Diquino- and Quinonaphthothiazines as Potential Candidates for New Drugs

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Design, Synthesis, and Biological Evaluation of Newly Synthesized Cinnamide-Fluorinated Containing Compounds as Bioactive Anticancer Agents

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Modification of the phenyl ring B of phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates by pyridinyl moiety leads to novel antimitotics targeting the colchicine-binding site

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Synthesis, Characterization and Antibacterial Activity of Novel 2‐Oxo‐1,2‐dihydro‐1′ H ‐spiro[indoline‐3,2′‐quinazoline]‐4′‐carbohydrazones

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Unveiling the Untapped Potential of Bertagnini’s Salts in Microwave-Assisted Synthesis of Quinazolinones

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Search for molecular descriptors and computer prediction of biological activity in a series of S-derivatives (1,2,4-triazole-3(2H)-yl)methyl)thiopyrimidines

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近5年高被引文献
Trends in kinase drug discovery: targets, indications and inhibitor design

review Full Text OpenAlex 690 FWCI99.32603535

Late-stage diversification of indole skeletons through nitrogen atom insertion

article Full Text OpenAlex 313 FWCI53.81968131

ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer

review Full Text OpenAlex 302 FWCI19.40895302

Dihydroartemisinin: A Potential Natural Anticancer Drug

review Full Text OpenAlex 222 FWCI23.3527494

Properties of FDA-approved small molecule protein kinase inhibitors: A 2022 update

review Full Text OpenAlex 199 FWCI24.01617978

Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer

article Full Text OpenAlex 194 FWCI27.12618408

Carbon-to-nitrogen single-atom transmutation of azaarenes

article Full Text OpenAlex 153 FWCI29.50927579

Unified Access to Pyrimidines and Quinazolines Enabled by N–N Cleaving Carbon Atom Insertion

article Full Text OpenAlex 149 FWCI25.62023168

Caspase‐3: A primary target for natural and synthetic compounds for cancer therapy

review Full Text OpenAlex 146 FWCI12.28908583

Application and synthesis of thiazole ring in clinically approved drugs

review Full Text OpenAlex 138 FWCI26.61620953