专题:Quinazolinone synthesis and applications

This cluster of papers focuses on the chemistry, synthesis, and pharmacological properties of quinazoline compounds, including indirubin derivatives. It covers a wide range of topics such as inhibition of protein kinases, antitumor activity, antimicrobial effects, and anti-inflammatory properties.
最新文献
Phase II study of afatinib for advanced non-small cell lung cancer with uncommon epidermal growth factor receptor mutations, including compound mutations detected by next-generation sequencing

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SynthesIs, antiproliferative evaluation and in silico studies of new quinazoline derivatives as VEGFR-2 inhibitors

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4-Methylesculetin alleviated aflatoxin B1-induced liver injury and ferritinophagy through adenosine monophosphate-activated protein kinase (AMPK) - target of rapamycin (TOR) -unc-51-like autophagy activating kinase (Ulk) axis in grass carp (Ctenopharyngodon idella)

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Synthesis, biological evaluation and molecular modeling studies of quinazolin-4(3H)-one and benzenesulfonamide hybrids as potential anticancer agents

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One-pot Synthesis of Hexahydroquinazolinone using Co-Al2O3-SO3H as an Efficient Catalyst

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Design and Synthesis of Imidazo[2,1-B]Thiazole Derivatives as Potent and Selective Phosphatidylinositol 4-Kinase Iiiβ Inhibitors for Antiviral Activity

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Vanadium‐Catalyzed Decarboxylative Alkylation/Cyclization of Alkenes With PhI(O2CR)2 to Construct Alkylated Indolo[2,1‐b]quinazolinones and Isoquinoline‐1,3‐diones

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In Vitro Study of Tryptanthrin and its Derivatives: A Potent Alkaloid Compound from Fluorescent Bacteria Pseudomonas sps in Anticancer Effects through Drug Design

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Iodine-Promoted Intermolecular Cyclization for the Synthesis of 2-Phenylquinazolines

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Practical Synthesis of 3-Substituted Pyrimidin-4-ones and 4(3H)-Quinazolinones from Nitriles: Mechanistic Insights, Scope, and Scale-Up

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近5年高被引文献
Trends in kinase drug discovery: targets, indications and inhibitor design

review Full Text OpenAlex 599 FWCI26.164

ERK: A Double-Edged Sword in Cancer. ERK-Dependent Apoptosis as a Potential Therapeutic Strategy for Cancer

review Full Text OpenAlex 242 FWCI5.647

Late-stage diversification of indole skeletons through nitrogen atom insertion

article Full Text OpenAlex 212 FWCI24.901

Properties of FDA-approved small molecule protein kinase inhibitors: A 2022 update

review Full Text OpenAlex 191 FWCI4.023

Dihydroartemisinin: A Potential Natural Anticancer Drug

review Full Text OpenAlex 178 FWCI3.236

Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer

article Full Text OpenAlex 155 FWCI21.353

Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma

review Full Text OpenAlex 122 FWCI4.5

Caspase‐3: A primary target for natural and synthetic compounds for cancer therapy

review Full Text OpenAlex 116 FWCI3.248

Drug Resistance in Nontuberculous Mycobacteria: Mechanisms and Models

review Full Text OpenAlex 115 FWCI4.228

Unified Access to Pyrimidines and Quinazolines Enabled by N–N Cleaving Carbon Atom Insertion

article Full Text OpenAlex 111 FWCI13.038