专题：Galectins and Cancer Biology

This cluster of papers explores the diverse roles of galectins in immune regulation, inflammation, cancer, macrophage activation, T cell dysfunction, fibrosis, angiogenesis, heart failure, and autoimmunity. Galectins are implicated in modulating various aspects of immune responses and have potential implications for therapeutic interventions in a range of diseases.
最新文献
Analysis of human factor H-related gene and protein expression in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation

article Full Text OpenAlex

Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape

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Sequencing validates deep learning models for EHR-based detection of Noonan syndrome in pediatric patients

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Anti-galectin-9 therapy synergizes with EGFR inhibition to reprogram the tumor microenvironment and overcome immune evasion

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Galectin-3: Integrator of Signaling via Hexosamine Flux

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Predicting disease-overarching therapeutic approaches for Congenital Disorders of Glycosylation using multi-OMICS

preprint Full Text OpenAlex

First-in-human phase I open-label study of the anti–TIM-3 monoclonal antibody INCAGN02390 in patients with select advanced or metastatic solid tumors

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SFX-01 is therapeutic against myeloproliferative disorders caused by activating mutations in Shp2

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MAN2A2-related glycosylation defects in autism and cognitive delay

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Regulatory T cells attenuate chronic inflammation and cardiac fibrosis in hypertrophic cardiomyopathy

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近5年高被引文献
Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy

article Full Text OpenAlex 475 FWCI36.329

Extracellular vesicles in immunomodulation and tumor progression

review Full Text OpenAlex 442 FWCI10.277

TIM-3 restrains anti-tumour immunity by regulating inflammasome activation

article Full Text OpenAlex 294 FWCI23.49

Roles of CA125 in diagnosis, prediction, and oncogenesis of ovarian cancer

review Full Text OpenAlex 288 FWCI10.642

Phase I/Ib Clinical Trial of Sabatolimab, an Anti–TIM-3 Antibody, Alone and in Combination with Spartalizumab, an Anti–PD-1 Antibody, in Advanced Solid Tumors

article Full Text OpenAlex 270 FWCI22.527

Bispecific Antibodies: From Research to Clinical Application

review Full Text OpenAlex 244 FWCI9.517

A Useful Guide to Lectin Binding: Machine-Learning Directed Annotation of 57 Unique Lectin Specificities

article Full Text OpenAlex 231 FWCI21.926

Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity

review Full Text OpenAlex 225 FWCI4.836

The human O-GlcNAcome database and meta-analysis

review Full Text OpenAlex 212 FWCI5.504

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

review Full Text OpenAlex 210 FWCI5.845