专题：Enzyme function and inhibition

This cluster of papers explores the role of carbonic anhydrases in medicine and biotechnology, focusing on their inhibitors, activators, and their potential therapeutic applications in cancer therapy and CO2 capture. The papers cover a wide range of topics including tumor hypoxia, drug discovery, enzyme structure and function, and the use of carbonic anhydrases as targets for medicinal chemistry.
最新文献
Overcoming Chemotherapy Resistance in Metastatic Cancer: A Comprehensive Review

review Full Text OpenAlex

Inhibition Effects of Some Non‐Proteinogenic Amino Acid Derivatives on Carbonic Anhydrase Isoenzymes and Acetylcholinesterase: An In Vitro Inhibition and Molecular Modeling Studies

article Full Text OpenAlex

Streamlining heterologous expression of top carbonic anhydrases in Escherichia coli: bioinformatic and experimental approaches

article Full Text OpenAlex

In silico and in vitro inhibition abilities of novel benzene sulfonamides on carbonic anhydrase and choline esterases

article Full Text OpenAlex

Investigation of cholinesterase and α-glucosidase enzyme activities, and molecular docking and dft studies for 1,2-disubstituted cyclopentane derivatives with phenyl and benzyl units

article Full Text OpenAlex

Novel thiazolotriazole and triazolothiadiazine scaffolds as selective tumor associated carbonic anhydrase inhibitors endowed with cathepsin B inhibition

article Full Text OpenAlex

Guyparkeria halophila: Novel cell platform for the efficient valorization of carbon dioxide and thiosulfate into ectoine

article Full Text OpenAlex

Clinical impact of carbonic anhydrase 9 expression on neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma

article Full Text OpenAlex

Identification of Novel Target DCTPP1 for Colorectal Cancer Therapy with the Natural Small‐Molecule Inhibitors Regulating Metabolic Reprogramming

article Full Text OpenAlex

Physiological modeling of the metaverse of the Mycobacterium tuberculosis β-CA inhibition mechanism

article Full Text OpenAlex

近5年高被引文献
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

article Full Text OpenAlex 377 FWCI34.42894682

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

article Full Text OpenAlex 377 FWCI70.97655876

Thiazole Ring—A Biologically Active Scaffold

review Full Text OpenAlex 285 FWCI19.79908273

Reactive Oxygen Species (ROS): Key Components in Cancer Therapies

review Full Text OpenAlex 262 FWCI27.25800583

Discovery of sulfadrug–pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors

article Full Text OpenAlex 260 FWCI21.16453671

A Carbonic Anhydrase IX (CAIX)‐Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti‐Tumor Immunity

article Full Text OpenAlex 219 FWCI16.0928505

Targeting Drug Chemo-Resistance in Cancer Using Natural Products

review Full Text OpenAlex 193 FWCI20.07772177

Emerging role of carbonic anhydrase inhibitors

article Full Text OpenAlex 183 FWCI15.11752622

Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation

review Full Text OpenAlex 172 FWCI12.97181282

State-of-the-Art Review of the Applicability and Challenges of Microbial-Induced Calcite Precipitation (MICP) and Enzyme-Induced Calcite Precipitation (EICP) Techniques for Geotechnical and Geoenvironmental Applications

article Full Text OpenAlex 157 FWCI10.88998852