专题：Enzyme function and inhibition

This cluster of papers explores the role of carbonic anhydrases in medicine and biotechnology, focusing on their inhibitors, activators, and their potential therapeutic applications in cancer therapy and CO2 capture. The papers cover a wide range of topics including tumor hypoxia, drug discovery, enzyme structure and function, and the use of carbonic anhydrases as targets for medicinal chemistry.
最新文献
The Role of In Vivo, In Vitro and Pharmacogenomic Diagnostic Approaches to Sulfonamide Allergy

article Full Text OpenAlex

Deciphering enzyme inhibition of thiazole assemblies for diabetes management via molecular docking, dynamic simulation, DFT and kinetic study: A computational therapeutic strategy

article Full Text OpenAlex

Molecular mechanism of redox regulation of the alpha-carboxysomal carbonic anhydrase CsoSCA

article Full Text OpenAlex

Disrupting Leishmania redox homeostasis: Mechanistic insights into a platinum-based antileishmanial complex

article Full Text OpenAlex

Unnatural amino acid compounds as potent multi-target inhibitors of aldose reductase, α-glucosidase, and α-amylase: integrated in vitro, SAR, and molecular dynamics insights

article Full Text OpenAlex

Synthesis, antioxidant activity and docking studies of 2-(aroylmethylthio)imidazoles and 3-arylimidazo[2,1-b]thiazoles

article Full Text OpenAlex

Multi-targeted pyrazole scaffolds: synthesis, mechanistic insights, and therapeutic potential in anticancer, antioxidant, and anti-inflammatory applications

article Full Text OpenAlex

Design, Synthesis, In Vitro and Molecular Docking Evaluation of Triphenylphosphonium‐Hydrazone Hybrids Against MDR Bacteria, AChE, and Laryngeal Cancer (Hep‐2)

article Full Text OpenAlex

A guard cell carbonic anhydrase binds and regulates SLAC1 separate from its catalytic activity

article Full Text OpenAlex

Genomic and metagenomic survey of microbial carbonic anhydrase genes reveals novel clades, high diversity, and biome specificity

article Full Text OpenAlex

近5年高被引文献
The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

article Full Text OpenAlex 426 FWCI60.9369

Application of microbial-induced carbonate precipitation (MICP) techniques to remove heavy metal in the natural environment: A critical review

review Full Text OpenAlex 166 FWCI19.6636

Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile

article Full Text OpenAlex 147 FWCI11.9775

Recent advances on anticancer activity of coumarin derivatives

article Full Text OpenAlex 144 FWCI14.7005

Carbonic anhydrase for CO2 capture, conversion and utilization

review Full Text OpenAlex 125 FWCI9.36

Carbonic anhydrase to boost CO2 sequestration: Improving carbon capture utilization and storage (CCUS)

review Full Text OpenAlex 113 FWCI8.2333

Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology

review Full Text OpenAlex 109 FWCI8.6794

Identification of potent inhibitors of NEK7 protein using a comprehensive computational approach

article Full Text OpenAlex 108 FWCI15.694

Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside

article Full Text OpenAlex 106 FWCI8.8403

TXNIP: A Double‐Edged Sword in Disease and Therapeutic Outlook

review Full Text OpenAlex 105 FWCI8.2336