专题：Enzyme function and inhibition

This cluster of papers explores the role of carbonic anhydrases in medicine and biotechnology, focusing on their inhibitors, activators, and their potential therapeutic applications in cancer therapy and CO2 capture. The papers cover a wide range of topics including tumor hypoxia, drug discovery, enzyme structure and function, and the use of carbonic anhydrases as targets for medicinal chemistry.
最新文献
Understanding binding behavior of human carbonic anhydrase II with aromatic benzenesulfonamides by molecular dynamics simulations and biophysical characterization

article Full Text OpenAlex

The reducing effect of TNF-α on carbonic anhydrase III gene expression in colon carcinoma and osteosarcoma cells

article Full Text OpenAlex

Discovery of novel thiourea benzenesulfonamides based 1,8-naphthalimide derivatives as carbonic anhydrase IX inhibitors that induce ferroptosis and inhibit triple-negative breast cancer metastasis

article Full Text OpenAlex

Facile synthesis of aminobiphenyl sulfonamides via Chan–Lam coupling and their biological evaluation as potent carbonic anhydrase inhibitors

article Full Text OpenAlex

Urinary carbonic anhydrase 1 as a marker of hematuria in IgA nephropathy

article Full Text OpenAlex

Evaluation of Anti-Cancer and Anti-Enzyme Activities of Imidazole Derivative Molecules with Theoretical Calculations

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Supramolecular vehicles based on cyclodextrin for dual-function delivery of podophyllotoxin: Effective treatment for tumors

article Full Text OpenAlex

Mushroom Bioactive Molecules as Anticancerous Agents: An Overview

review Full Text OpenAlex

Synthesis of 6-ethoxyphenyl 4-fluorobenzenesulfonate-tagged thiosemicarbazones as carbonic anhydrase inhibitors: In-vitro and in silico approach

article Full Text OpenAlex

The Steady State Approximation in Enzyme Kinetics: Reflections in Its Centennial Year

preprint Full Text OpenAlex

近5年高被引文献
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

article Full Text OpenAlex 364 FWCI27.48

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

article Full Text OpenAlex 287 FWCI49.29

Discovery of sulfadrug–pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors

article Full Text OpenAlex 240 FWCI16.881

Thiazole Ring—A Biologically Active Scaffold

review Full Text OpenAlex 222 FWCI5.618

Reactive Oxygen Species (ROS): Key Components in Cancer Therapies

review Full Text OpenAlex 188 FWCI5.278

A Carbonic Anhydrase IX (CAIX)‐Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti‐Tumor Immunity

article Full Text OpenAlex 182 FWCI12.292

Emerging role of carbonic anhydrase inhibitors

article Full Text OpenAlex 160 FWCI11.591

Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation

review Full Text OpenAlex 152 FWCI3.862

State-of-the-Art Review of the Applicability and Challenges of Microbial-Induced Calcite Precipitation (MICP) and Enzyme-Induced Calcite Precipitation (EICP) Techniques for Geotechnical and Geoenvironmental Applications

article Full Text OpenAlex 144 FWCI9.331

Targeting Drug Chemo-Resistance in Cancer Using Natural Products

review Full Text OpenAlex 143 FWCI5.133