专题：Enzyme function and inhibition

This cluster of papers explores the role of carbonic anhydrases in medicine and biotechnology, focusing on their inhibitors, activators, and their potential therapeutic applications in cancer therapy and CO2 capture. The papers cover a wide range of topics including tumor hypoxia, drug discovery, enzyme structure and function, and the use of carbonic anhydrases as targets for medicinal chemistry.
最新文献
Design, Synthesis, and Biological Evaluation of New Nitrogen and Sulfur-Containing Heterocycles as Potent Anticancer Agents: Insights from Apoptosis, Molecular Docking, and MD Simulations

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Investigating the Inhibitory Properties of Diazo and Pyrazole‐Carboxamide‐Linked Benzenesulfonamides Against Carbonic Anhydrase Isoforms I, II, IX, and XII

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Design, synthesis, biological evaluation and molecular docking study of oxadiazole-based sulfonamide derivatives as potent anti-glucosidase and anti-urease agents

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Synthesis and multilevel evaluation of benzimidazole-based anticancer compounds: DNA/serum albumin interaction, and in-depth theoretical insights

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Identification of Sulfonamide‐Based Thiazolidine‐2,4‐Dione Derivatives as VEGFR‐2 and Tumor‐Associated hCA IX Inhibitors With Hypoxia‐Targeted Anti‐Colorectal Cancer Activity

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Carbonic anhydrase VIII as a regulator of intracellular calcium signaling: mechanistic insights and implications in human disease

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2,3-Dihydroquinazolin-4(1H)-one derivatives as potent aldose reductase inhibitors: a combined experimental and computational study

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Novel pyridazinone-based N-phenylacetamides as α-glucosidase-selective and dual α-glucosidase/aldose reductase inhibitors: Synthesis, SAR analysis, and cytotoxicity evaluation

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Synthesis, characterization, and biological evaluation of novel silver(I) complexes containing sulfa drug-based azo ligands and ciprofloxacin: Insights from computational analysis and mechanistic studies

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1H-Indazole-3-Carboxylic Acid Derivatives as Disruptors of the Oncogenic MTDH–SND1 Protein–Protein Interaction: An In Silico-to-In Vitro Study

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近5年高被引文献
The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

article Full Text OpenAlex 446 FWCI49.4841

Application of microbial-induced carbonate precipitation (MICP) techniques to remove heavy metal in the natural environment: A critical review

article Full Text OpenAlex 176 FWCI15.1118

Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile

article Full Text OpenAlex 157 FWCI10.7416

Recent advances on anticancer activity of coumarin derivatives

article Full Text OpenAlex 149 FWCI13.2165

Carbonic anhydrase for CO2 capture, conversion and utilization

article Full Text OpenAlex 144 FWCI8.4678

Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology

article Full Text OpenAlex 131 FWCI7.8426

Carbonic anhydrase to boost CO2 sequestration: Improving carbon capture utilization and storage (CCUS)

article Full Text OpenAlex 123 FWCI7.4504

Benzimidazole and its derivatives: Recent Advances (2020–2022)

article Full Text OpenAlex 116 FWCI13.2567

Overcoming Chemotherapy Resistance in Metastatic Cancer: A Comprehensive Review

article Full Text OpenAlex 114 FWCI18.3369

Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside

article Full Text OpenAlex 114 FWCI8.0758