专题:Enzyme function and inhibition

This cluster of papers explores the role of carbonic anhydrases in medicine and biotechnology, focusing on their inhibitors, activators, and their potential therapeutic applications in cancer therapy and CO2 capture. The papers cover a wide range of topics including tumor hypoxia, drug discovery, enzyme structure and function, and the use of carbonic anhydrases as targets for medicinal chemistry.
最新文献
Targeting OGG1 for Pulmonary Fibrosis: An Integrated In Silico Study with Quantum Chemical Calculations, Docking, Pharmacophore Modeling, Molecular Dynamics, and ADMET Evaluation

article Full Text OpenAlex

Anabaenopeptin B Chlorination Degradation Byproducts Retain Potent Carboxypeptidase B Inhibition

article Full Text OpenAlex

Carrier-free procyanidin-ferric nanonetworks loading gefitinib to inhibit TMEM16A-EGFR mutual activation loop for photothermally enhanced breast cancer targeted therapy

article Full Text OpenAlex

Bioinspired Carbonic Anhydrase Mimics with Zr–OH Sites and Size-Tunable Nanopockets for Efficient Bidirectional Catalysis of CO 2 Hydration

article Full Text OpenAlex

Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment

review Full Text OpenAlex

Statement of Retraction: Dependence on linkers’ flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents

article Full Text OpenAlex

Assessment of antioxidant, antimicrobial, antibiofilm, carbonic anhydrase and α-glucosidase inhibitory activities of Alchemilla vulgaris L. extracts

article Full Text OpenAlex

In vitro investigation on inhibition potential of deucravacitinib toward human carboxylesterase (CES) 2

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Decision letter for "Salophen-type Macrocyclic Schiff Base Ligand and its Metal Complexes: Exploring in vitro Anticancer Efficacy via in silico Topoisomerase IIꞵ Enzyme Targeting"

peer-review Full Text OpenAlex

Review for "Salophen-type Macrocyclic Schiff Base Ligand and its Metal Complexes: Exploring in vitro Anticancer Efficacy via in silico Topoisomerase IIꞵ Enzyme Targeting"

peer-review Full Text OpenAlex

近5年高被引文献
The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

article Full Text OpenAlex 394 FWCI74.25536718

Application of microbial-induced carbonate precipitation (MICP) techniques to remove heavy metal in the natural environment: A critical review

review Full Text OpenAlex 155 FWCI25.40171414

Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile

article Full Text OpenAlex 140 FWCI16.86047464

Recent advances on anticancer activity of coumarin derivatives

article Full Text OpenAlex 134 FWCI22.86906586

Carbonic anhydrase for CO2 capture, conversion and utilization

review Full Text OpenAlex 111 FWCI13.29146906

Identification of potent inhibitors of NEK7 protein using a comprehensive computational approach

article Full Text OpenAlex 103 FWCI27.12481965

Carbonic anhydrases in metazoan model organisms: molecules, mechanisms, and physiology

review Full Text OpenAlex 101 FWCI12.3069158

Cardio-Oncology Drug Interactions: A Scientific Statement From the American Heart Association

article Full Text OpenAlex 98 FWCI21.38515173

Carbonic anhydrase to boost CO2 sequestration: Improving carbon capture utilization and storage (CCUS)

review Full Text OpenAlex 98 FWCI11.69157001

Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside

article Full Text OpenAlex 96 FWCI12.55305411