This cluster of papers explores the impact of obesity on skin physiology and the development of various skin disorders, including cutaneous manifestations, musculoskeletal disorders, diabetes mellitus-related skin issues, acanthosis nigricans, granuloma annulare, scleromyxedema, necrobiosis lipoidica, and the concept of the immunocompromised district. The papers cover a wide range of topics related to the dermatological complications and musculoskeletal manifestations associated with obesity and diabetes mellitus.