专题：Porphyrin Metabolism and Disorders

This cluster of papers explores the molecular mechanisms of heme biosynthesis, including the catalysis by cobalamin-dependent enzymes, genetic mutations leading to porphyrias, microbial production of vitamin B12, and the use of RNA interference therapy and liver transplantation for the treatment of related disorders. It also delves into metabolic engineering and genomic analysis related to heme biosynthesis pathways.
最新文献
Responses to ‘Red fluorescence in porphyria cutanea tarda’

article Full Text OpenAlex

Vitamin B12 Deficiency and the Nervous System: Beyond Metabolic Decompensation—Comparing Biological Models and Gaining New Insights into Molecular and Cellular Mechanisms

article Full Text OpenAlex

Complex system modelling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria

preprint Full Text OpenAlex

The mitochondrial citrate synthase from Tetrahymena thermophila does not form an intermediate filament

article Full Text OpenAlex

Engineering Neuroglobin for Synthesis of Chiral Organoborons via Carbene B–H Insertion

article Full Text OpenAlex

Neurodegeneration with brain iron accumulation

book-chapter Full Text OpenAlex

Computational Stabilization of a Non‐Heme Iron Enzyme Enables Efficient Evolution of New Function

article Full Text OpenAlex

Ataxia Telangiectasia: Myriad of Clinical Presentations

letter Full Text OpenAlex

Correction to “Erythropoietic protoporphyrias: Pathogenesis, diagnosis and management”

erratum Full Text OpenAlex

S4342 A Case of Hereditary Coproporphyria Treated With Givosiran After Failed Hemin Therapy

article Full Text OpenAlex

近5年高被引文献
Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1

article Full Text OpenAlex 452 FWCI65.44309932

Lumasiran: First Approval

review Full Text OpenAlex 268 FWCI38.91211311

Molecular Mechanisms of Iron and Heme Metabolism

review Full Text OpenAlex 238 FWCI53.8917917

Classic highlights in porphyrin and porphyrinoid total synthesis and biosynthesis

review Full Text OpenAlex 186 FWCI11.73369721

2.7 Å cryo-EM structure of ex vivo RML prion fibrils

article Full Text OpenAlex 137 FWCI16.86047464

Vitamin B12status in health and disease: a critical review. Diagnosis of deficiency and insufficiency – clinical and laboratory pitfalls

review Full Text OpenAlex 124 FWCI21.02635604

Creation from Confusion and Fusion in the Porphyrin World─The Last Three Decades of N-Confused Porphyrinoid Chemistry

review Full Text OpenAlex 111 FWCI13.6531726

Microbial and Genetic Resources for Cobalamin (Vitamin B12) Biosynthesis: From Ecosystems to Industrial Biotechnology

review Full Text OpenAlex 104 FWCI7.21739962

Metal Binding Proteins

article Full Text OpenAlex 102 FWCI10.31384005

Disorders of purine biosynthesis metabolism

review Full Text OpenAlex 100 FWCI7.02233476