专题：Toxin Mechanisms and Immunotoxins

This cluster of papers focuses on the development and efficacy of immunotoxin therapy for cancer treatment, with a particular emphasis on ricin poisoning, ribosome-inactivating proteins, and targeted therapy using recombinant immunotoxins. It also explores the use of IL-13 receptor and mistletoe extract in cancer therapy.
最新文献
Next-generation T cell engagers in oncology: Pharmacologic evolution from bispecific to trispecific antibodies

article Full Text OpenAlex

Expansion of secreted cystine knot proteins reveals virulence factors in the human fungal pathogen Histoplasma

article Full Text OpenAlex

Adiantum capillus‐veneris: A Comprehensive Review of Its Medicinal Properties, Bioactive Compounds, and Advanced Extraction Techniques

review Full Text OpenAlex

Structural mechanism of the agonist binding on human TRPC3 channel

article Full Text OpenAlex

Generation of the augmented IL-15-secreting anti-HER2 chimeric antigen receptor (CAR)-NK cells: an encouraging immunotherapeutic tool

article Full Text OpenAlex

Snake venom-derived peptides as anticancer candidates: Pioneering next-generation therapies

review Full Text OpenAlex

Clinically approved immunotoxins targeting hematological cancers: “the best of both worlds”

article Full Text OpenAlex

Predicting Pose Distribution of Protein Domains Connected by Flexible Linkers Is an Unsolved Problem

article Full Text OpenAlex

Accelerated In Silico Discovery of SGR-1505 : A Potent MALT1 Allosteric Inhibitor for the Treatment of Mature B-Cell Malignancies

article Full Text OpenAlex

Bee venom in pharmacology: Mechanistic insights from pro-inflammatory trigger to anti-inflammatory therapeutic agent

review Full Text OpenAlex

近5年高被引文献
Plant-derived natural products for drug discovery: current approaches and prospects

review Full Text OpenAlex 443 FWCI99.08560275

A Randomized, Phase III Trial to Evaluate Rucaparib Monotherapy as Maintenance Treatment in Patients With Newly Diagnosed Ovarian Cancer (ATHENA–MONO/GOG-3020/ENGOT-ov45)

article Full Text OpenAlex 332 FWCI49.0093847

Olaparib plus bevacizumab first-line maintenance in ovarian cancer: final overall survival results from the PAOLA-1/ENGOT-ov25 trial

article Full Text OpenAlex 278 FWCI66.05197338

A wheat resistosome defines common principles of immune receptor channels

article Full Text OpenAlex 268 FWCI47.26855778

Ribosome biogenesis in disease: new players and therapeutic targets

review Full Text OpenAlex 266 FWCI54.49625988

The role of galectins in immunity and infection

review Full Text OpenAlex 231 FWCI45.18729022

Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery

review Full Text OpenAlex 181 FWCI21.75273607

Structural basis of NPR1 in activating plant immunity

article Full Text OpenAlex 176 FWCI32.16394345

Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes

article Full Text OpenAlex 168 FWCI20.30641107

NLR immune receptor–nanobody fusions confer plant disease resistance

article Full Text OpenAlex 144 FWCI41.02635295