This cluster of papers focuses on the emergence, transmission, and impact of zoonotic diseases, highlighting the interconnectedness of human, animal, and environmental health. It emphasizes the One Health approach, addressing the complex interactions between humans, animals, and ecosystems to prevent and control zoonotic diseases. The role of biodiversity, wildlife health, and ecosystem changes in disease emergence and spread is a central theme, along with the global implications of pandemic prevention and the influence of globalization on disease dynamics.