专题：Peptidase Inhibition and Analysis

This cluster of papers explores the role of fibroblast activation in cancer progression, focusing on the expression of fibroblast activation protein, immunosuppression in the tumor microenvironment, N-terminal acetylation of proteins, protease inhibitors for cancer therapy, angiogenesis, and PET imaging to target stromal cells in the tumor microenvironment.
最新文献
Anti-FAP CAR T cells produced in vivo reduce fibrosis and restore liver homeostasis in metabolic dysfunction–associated steatohepatitis

article Full Text OpenAlex

Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo

article Full Text OpenAlex

Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia

article Full Text OpenAlex

Suboptimal codon pairs trigger ribosome collisions and cellular quality control responses in tRNA modification mutants

article Full Text OpenAlex

Spatial metabolic and protein profiles reveal astragaloside IV attenuates diabetic nephropathy by inhibiting ST13 acetylation at lysine 14 to restore amino acid metabolism dysregulation

article Full Text OpenAlex

Effective Degradation of Wild‐Type and Mutant EGFR Using Self‐Assembling Peptide‐Derived PROTAC Nanoparticles (NanoTACs) for Cancer Therapy

article Full Text OpenAlex

Canustatins A and B, Two Polyketides from Streptomyces canus NA07887

article Full Text OpenAlex

Overcoming Challenges in the Metabolism of Peptide Therapeutics: Strategies and Case Studies for Clinical Success

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Tumor microenvironment–targeted PROTAC nanoparticle self-assembly broadly predicted by structural descriptors

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In Silico design and evaluation of novel anti-tubercular agents as Inha inhibitors through a virtual screening approach

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近5年高被引文献
PROTAC targeted protein degraders: the past is prologue

review Full Text OpenAlex 2796 FWCI225.9681

Durvalumab plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer

article Full Text OpenAlex 1006 FWCI206.8703

Targeting HER2-positive breast cancer: advances and future directions

review Full Text OpenAlex 993 FWCI97.0008

Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer

article Full Text OpenAlex 862 FWCI75.3235

Efficacy and Safety of Trastuzumab Deruxtecan in Patients With HER2-Expressing Solid Tumors: Primary Results From the DESTINY-PanTumor02 Phase II Trial

article Full Text OpenAlex 794 FWCI184.7225

Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

review Full Text OpenAlex 793 FWCI199.5318

Targeted protein degradation: mechanisms, strategies and application

review Full Text OpenAlex 791 FWCI62.5424

Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity

review Full Text OpenAlex 645 FWCI150.6758

Ide-cel or Standard Regimens in Relapsed and Refractory Multiple Myeloma

article Full Text OpenAlex 642 FWCI187.5419

Protein degraders enter the clinic — a new approach to cancer therapy

review Full Text OpenAlex 554 FWCI86.557