专题：Signaling Pathways in Disease

This cluster of papers focuses on the role of Calcineurin-NFAT signaling in transcriptional regulation, with a particular emphasis on its involvement in cancer progression, cardiac hypertrophy, and inflammatory responses. The cluster also explores the impact of Prolyl Isomerase Pin1, EMMPRIN/CD147, and immunophilins in modulating this signaling pathway.
最新文献
NF-κB Signaling Pathway: A Central Hub in the Pathogenesis and Therapeutic Targeting of Immunological Diseases

article Full Text OpenAlex

MFSD2A as a prognostic biomarker in low-grade glioma: mechanistic links to immune suppression

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Non-canonically regulated heterochronic expression of Hsp70 drives clonal expansion and invasion in Drosophila epithelial tumours

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Characterization of a novel assay for full-length endotrophin in heart failure with preserved ejection fraction

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CBP-IDRs regulate acetylation and gene expression

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Exploring the role of sialidases in Galectin-1-associated resistance to cancer therapies

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Bisdemethoxycurcumin extends lifespan and healthspan in Caenorhabditis elegans via modulation of EGFR-linked signaling pathways

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Nuclear receptor subfamily 4 group a member 2 induces a Warburg-like effect and promotes phospholipids synthesis in the mouse heart

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A Novel Monocyte-derived Antigen Presenting Cell-T regulatory Cell Axis Contributes to Skin Wound healing and is Impaired in Diabetic Mice

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Cell-type specificity of Tim-3 in respiratory diseases: from mechanisms to clinical translation

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近5年高被引文献
Signaling pathways and targeted therapy for myocardial infarction

review Full Text OpenAlex 779 FWCI60.1457

Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma

article Full Text OpenAlex 488 FWCI138.0369

OpenFold: retraining AlphaFold2 yields new insights into its learning mechanisms and capacity for generalization

article Full Text OpenAlex 273 FWCI54.4286

Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction

article Full Text OpenAlex 252 FWCI36.6479

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

review Full Text OpenAlex 228 FWCI23.4295

Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS

article Full Text OpenAlex 220 FWCI32.8013

Targeting immune–fibroblast cell communication in heart failure

article Full Text OpenAlex 183 FWCI71.5533

Insights Into the Role of Matrix Metalloproteinases in Cancer and its Various Therapeutic Aspects: A Review

review Full Text OpenAlex 177 FWCI15.0947

TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling

article Full Text OpenAlex 168 FWCI13.6592

Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain

article Full Text OpenAlex 164 FWCI13.6392