专题：Signaling Pathways in Disease

This cluster of papers focuses on the role of Calcineurin-NFAT signaling in transcriptional regulation, with a particular emphasis on its involvement in cancer progression, cardiac hypertrophy, and inflammatory responses. The cluster also explores the impact of Prolyl Isomerase Pin1, EMMPRIN/CD147, and immunophilins in modulating this signaling pathway.
最新文献
Dual costimulation blockade with the CD154-specific fusion protein dazodalibep and belatacept for prophylaxis of kidney allograft rejection

article Full Text OpenAlex

6-PPD quinone induces lifespan reduction by causing immunosuppression via DAF-16/PMK-1 signaling in Caenorhabditis elegans

article Full Text OpenAlex

Streptococcus pneumoniae upregulates Toll2, Toll9, and defensin genes in Bombyx larvae infection model

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The host protein cyclophilin A restricts nuclear entry of HIV-1 mutants by reducing the elasticity of the viral capsid

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A first-in-class small-molecule inhibitor targeting AVIL exhibits safety and antitumor efficacy in preclinical models of glioblastoma

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Ecdysone-mediated intestinal growth contributes to microbiota-driven developmental plasticity under malnutrition

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Disease tolerance and infection pathogenesis age-related tradeoffs in mice

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NFAT mediates pro-tumorigenic inflammation in cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

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Calcineurin depletion coincides with phosphorylated TDP-43 deposition in a mouse model of ALS/FTLD-TDP

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Mosloflavone induces pancreatic α cells transdifferentiation into β cells through PDX1

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近5年高被引文献
Signaling pathways and targeted therapy for myocardial infarction

review Full Text OpenAlex 751 FWCI60.1136

Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction

article Full Text OpenAlex 433 FWCI63.5306

OpenFold: retraining AlphaFold2 yields new insights into its learning mechanisms and capacity for generalization

article Full Text OpenAlex 248 FWCI53.5169

Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction

article Full Text OpenAlex 235 FWCI35.467

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

review Full Text OpenAlex 219 FWCI23.432

Cardiac Resident Macrophage-Derived Legumain Improves Cardiac Repair by Promoting Clearance and Degradation of Apoptotic Cardiomyocytes After Myocardial Infarction

article Full Text OpenAlex 216 FWCI32.8357

Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS

article Full Text OpenAlex 210 FWCI32.8661

Inclisiran and cardiovascular events: a patient-level analysis of phase III trials

article Full Text OpenAlex 198 FWCI39.6763

Insights Into the Role of Matrix Metalloproteinases in Cancer and its Various Therapeutic Aspects: A Review

review Full Text OpenAlex 172 FWCI15.0964

Targeting immune–fibroblast cell communication in heart failure

article Full Text OpenAlex 164 FWCI67.858