专题：Signaling Pathways in Disease

This cluster of papers focuses on the role of Calcineurin-NFAT signaling in transcriptional regulation, with a particular emphasis on its involvement in cancer progression, cardiac hypertrophy, and inflammatory responses. The cluster also explores the impact of Prolyl Isomerase Pin1, EMMPRIN/CD147, and immunophilins in modulating this signaling pathway.
最新文献
Disease tolerance and infection pathogenesis age-related tradeoffs in mice

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Chronic stress antagonizes formation of stress granules

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C/EBPβ-induced alternative splicing of RCAN1 generates a potent TCR-T target in mesenchymal glioblastoma

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Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate

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Synergistic Interplay of Stimulatory Cofactors in the Activation of Adenylyl Cyclase Isoform 1

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Oxphos targeting of MYCN-amplified neuroblastoma

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High-throughput screening and structure-guided design of small molecules enable modulation of SAL-PAP stress signaling

preprint Full Text OpenAlex

A non-canonical immunometabolic function of BRD3 during sepsis

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FER kinase governs invasive growth of head and neck squamous cell carcinoma through dynamic control of growth factor receptor activity

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The clinical and molecular spectrum of the KDM6B-related neurodevelopmental disorder

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近5年高被引文献
Signaling pathways and targeted therapy for myocardial infarction

review Full Text OpenAlex 705 FWCI85.16385732

Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction

article Full Text OpenAlex 394 FWCI85.09967595

OpenFold: retraining AlphaFold2 yields new insights into its learning mechanisms and capacity for generalization

article Full Text OpenAlex 225 FWCI95.5691978

Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction

article Full Text OpenAlex 221 FWCI47.62054405

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

review Full Text OpenAlex 202 FWCI31.78314077

Cardiac Resident Macrophage-Derived Legumain Improves Cardiac Repair by Promoting Clearance and Degradation of Apoptotic Cardiomyocytes After Myocardial Infarction

article Full Text OpenAlex 198 FWCI43.65216538

Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS

article Full Text OpenAlex 193 FWCI35.83438867

Inclisiran and cardiovascular events: a patient-level analysis of phase III trials

article Full Text OpenAlex 185 FWCI55.03053436

Insights Into the Role of Matrix Metalloproteinases in Cancer and its Various Therapeutic Aspects: A Review

review Full Text OpenAlex 160 FWCI21.20921648

TRIM22 inhibits osteosarcoma progression through destabilizing NRF2 and thus activation of ROS/AMPK/mTOR/autophagy signaling

article Full Text OpenAlex 159 FWCI19.01303512