专题：Chromatin Remodeling and Cancer

This cluster of papers focuses on the role of chromatin remodeling, particularly the SWI/SNF complexes and ARID1A mutations, in cancer development and progression. It explores the impact of these mutations on epigenetic regulation, tumor suppression, genomic analysis, oncogenic transformation, and synthetic lethality. Additionally, it delves into the involvement of chromatin remodeling in mammalian development.
最新文献
Renal Medullary Carcinoma: A Contemporary Update

article Full Text OpenAlex

Chromatin and Transcriptomic Engineering in Neurological Disorders: Emerging Human Cellular Models and Translational Approaches

article Full Text OpenAlex

DLK1 is a GATA1s-Driven Dependency and Therapeutic Target in Down Syndrome-Associated Myeloid Leukemia

article Full Text OpenAlex

Pan-cancer landscape of protein kinase D3: An integrative TCGA multi-omics analysis of clinical, molecular, and immunological roles

article Full Text OpenAlex

BAF complexes maintain accessibility at stimulus-responsive chromatin and are required for transcriptional stimulus responses

article Full Text OpenAlex

Plagl1 regulates the retinal progenitor cell to Müller glial cell transition

article Full Text OpenAlex

Integration of RNA Editing into Multiomics Machine Learning Models for Predicting Drug Responses in Breast Cancer Patients

article Full Text OpenAlex

H3K18 lactylation promotes osteogenic differentiation of periodontal ligament stem cells via IGF2BP1/m6A/BMP2

article Full Text OpenAlex

Subtype-specific dependencies and therapeutic opportunities in small cell lung cancer

article Full Text OpenAlex

The Genetic Drivers and Therapeutic Vulnerabilities of Metastatic Breast Cancer

preprint Full Text OpenAlex

近5年高被引文献
Durvalumab, with or without tremelimumab, plus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer: 3-year overall survival update from CASPIAN

article Full Text OpenAlex 306 FWCI28.9291

Proteolysis-targeting chimeras (PROTACs) in cancer therapy

article Full Text OpenAlex 300 FWCI23.7469

Molecular mechanisms of platinum‑based chemotherapy resistance in ovarian cancer (Review)

review Full Text OpenAlex 266 FWCI45.0312

Targeted therapy for head and neck cancer: signaling pathways and clinical studies

review Full Text OpenAlex 239 FWCI35.3187

H3K18 lactylation marks tissue-specific active enhancers

article Full Text OpenAlex 204 FWCI14.6469

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

article Full Text OpenAlex 200 FWCI16.2069

The 2021 World Health Organization Classification of Tumors of the Central Nervous System: What Neuroradiologists Need to Know

review Full Text OpenAlex 195 FWCI27.3671

Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC

article Full Text OpenAlex 178 FWCI26.3893

Molecular Characterization of KRAS Wild-type Tumors in Patients with Pancreatic Adenocarcinoma

article Full Text OpenAlex 170 FWCI16.6271

Menin Inhibition With Revumenib for KMT2A -Rearranged Relapsed or Refractory Acute Leukemia (AUGMENT-101)

article Full Text OpenAlex 166 FWCI69.5933