专题：Chromatin Remodeling and Cancer

This cluster of papers focuses on the role of chromatin remodeling, particularly the SWI/SNF complexes and ARID1A mutations, in cancer development and progression. It explores the impact of these mutations on epigenetic regulation, tumor suppression, genomic analysis, oncogenic transformation, and synthetic lethality. Additionally, it delves into the involvement of chromatin remodeling in mammalian development.
最新文献
Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomas

article Full Text OpenAlex

RDTA-10 OVARIAN CLEAR CELL CARCINOMA BRAIN METASTASES: CASE SERIES AND SYSTEMATIC REVIEW

article Full Text OpenAlex

Inhibition of both SWI/SNF ATPases by BRM014 impairs homologous recombination, sensitizes cells to DNA damage and PARP inhibitors, and activates the cGAS/STING response

article Full Text OpenAlex

Safety and efficacy of HH2853, a novel EZH1/2 dual inhibitor, in patients with refractory solid tumours or non-Hodgkin lymphomas: a phase I study

article Full Text OpenAlex

Beyond the liver: a case of solitary skull lesion with hepatocellular features without a primary malignancy

article Full Text OpenAlex

Identifying mitotic Histone H3.3 phospho-Serine 31 readers in diffuse midline glioma cells

grant Full Text OpenAlex

Complete Response to BET Inhibitor in Primary Pulmonary NUT Carcinoma with single-cell sequencing-based Analysis: A Case Report

article Full Text OpenAlex

H3K14: A histone site closely related to diseases

article Full Text OpenAlex

Blocking interplay between TERT and c-Myc: a new therapeutic strategy for BRAFV600E/pTERT double mutated tumors

article Full Text OpenAlex

Profiling of RUVBL2‐Induced Transcriptome Alterations Highlights a Critical Role for Chromatin Remodeling in Ovarian Cancer

article Full Text OpenAlex

近5年高被引文献
Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

article Full Text OpenAlex 741 FWCI62.406

Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma

article Full Text OpenAlex 425 FWCI161.512

Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer

article Full Text OpenAlex 235 FWCI14.477

Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers

article Full Text OpenAlex 233 FWCI18.951

New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia

article Full Text OpenAlex 211 FWCI14.555

Current Understanding of Neurofibromatosis Type 1, 2, and Schwannomatosis

review Full Text OpenAlex 182 FWCI5.383

Molecular mechanisms of platinum‑based chemotherapy resistance in ovarian cancer (Review)

review Full Text OpenAlex 182 FWCI9.847

Targeted therapy for head and neck cancer: signaling pathways and clinical studies

review Full Text OpenAlex 175 FWCI9.322

Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation

article Full Text OpenAlex 173 FWCI27.215

The pancreatic cancer genome revisited

review Full Text OpenAlex 171 FWCI5.008