专题：Chromatin Remodeling and Cancer

This cluster of papers focuses on the role of chromatin remodeling, particularly the SWI/SNF complexes and ARID1A mutations, in cancer development and progression. It explores the impact of these mutations on epigenetic regulation, tumor suppression, genomic analysis, oncogenic transformation, and synthetic lethality. Additionally, it delves into the involvement of chromatin remodeling in mammalian development.
最新文献
Hetairos is a histology-based artificial intelligence model for predicting central nervous system tumor methylation subtypes

article Full Text OpenAlex

IRF2 is an essential transcription factor with pathogenic and prognostic impact in multiple myeloma

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A signal-responsive cooperative transcription factor network determines alveolar macrophage identity

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Phase II trial of sodium phenylbutyrate and taurursodiol in Wolfram syndrome

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Dual E3 ligase recruitment by monovalent degraders for tunable SMARCA 2/4 degradation

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A ketogenesis-ferroptosis axis maintains leukemic stem cell survival and leukemia progression

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MYB-driven NAT10–IGF2BP3 RNA modification axis sustains MAPK signaling and promotes adenoid cystic carcinoma progression

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Engineering brain-penetrant PROTACs: Bridging molecular design and CNS delivery

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Proximity Binding Assay for PROTAC Ternary Complex Analysis

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Multi-layered molecular profiling informs the diagnosis and targeted therapy of desmoplastic small round cell tumor

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近5年高被引文献
Durvalumab, with or without tremelimumab, plus platinum-etoposide in first-line treatment of extensive-stage small-cell lung cancer: 3-year overall survival update from CASPIAN

article Full Text OpenAlex 341 FWCI25.9156

Proteolysis-targeting chimeras (PROTACs) in cancer therapy

article Full Text OpenAlex 333 FWCI21.5339

Molecular mechanisms of platinum‑based chemotherapy resistance in ovarian cancer (Review)

article Full Text OpenAlex 293 FWCI42.8194

Targeted therapy for head and neck cancer: signaling pathways and clinical studies

article Full Text OpenAlex 253 FWCI23.3775

H3K18 lactylation marks tissue-specific active enhancers

article Full Text OpenAlex 223 FWCI13.1552

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

article Full Text OpenAlex 214 FWCI14.643

Menin Inhibition With Revumenib for KMT2A -Rearranged Relapsed or Refractory Acute Leukemia (AUGMENT-101)

article Full Text OpenAlex 211 FWCI61.7144

The 2021 World Health Organization Classification of Tumors of the Central Nervous System: What Neuroradiologists Need to Know

article Full Text OpenAlex 202 FWCI24.4288

Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC

article Full Text OpenAlex 190 FWCI17.6208

Molecular Characterization of KRAS Wild-type Tumors in Patients with Pancreatic Adenocarcinoma

article Full Text OpenAlex 183 FWCI14.7691