专题：Chromatin Remodeling and Cancer

This cluster of papers focuses on the role of chromatin remodeling, particularly the SWI/SNF complexes and ARID1A mutations, in cancer development and progression. It explores the impact of these mutations on epigenetic regulation, tumor suppression, genomic analysis, oncogenic transformation, and synthetic lethality. Additionally, it delves into the involvement of chromatin remodeling in mammalian development.
最新文献
Tertiary lymphoid structures potentially promote immune checkpoint inhibitor response in SMARCB1-deficient medullary renal cell carcinoma

article Full Text OpenAlex

A case of surgically treated non-metastatic SMARCA4-deficient undifferentiated thoracic tumor: a case report and literature review

article Full Text OpenAlex

Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomas

preprint Full Text OpenAlex

The non-canonical BAF chromatin remodeling complex is a novel target of spliceosome dysregulation in SF3B1-mutated chronic lymphocytic leukemia

article Full Text OpenAlex

Multi-omics technologies and analyses provide the biological insights and therapeutic strategies for rare tumors

article Full Text OpenAlex

Risk-stratification for treatment de-intensification in WNT-pathway medulloblastoma: finding the optimal balance between survival and quality of survivorship

article Full Text OpenAlex

To slide or not to slide: key role of the hexasome in chromatin remodeling revealed

article Full Text OpenAlex

The Prognostic Role of BRD4 Expression in High-Grade Serous Ovarian Cancer

article Full Text OpenAlex

First description of a primary SMARCA4-deficient carcinoma of the salivary glands

article Full Text OpenAlex

Clinical, pathological, and molecular features of central nervous system tumors with BCOR internal tandem duplication

article Full Text OpenAlex

近5年高被引文献
Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

article Full Text OpenAlex 825 FWCI67.19698739

Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma

article Full Text OpenAlex 553 FWCI206.62526713

Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer

article Full Text OpenAlex 273 FWCI19.40895302

Comprehensive Genomic and Transcriptomic Analysis for Guiding Therapeutic Decisions in Patients with Rare Cancers

article Full Text OpenAlex 252 FWCI20.81968058

Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation

article Full Text OpenAlex 232 FWCI39.0529884

New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia

article Full Text OpenAlex 231 FWCI33.78278911

Molecular mechanisms of platinum‑based chemotherapy resistance in ovarian cancer (Review)

review Full Text OpenAlex 225 FWCI70.39389214

Current Understanding of Neurofibromatosis Type 1, 2, and Schwannomatosis

review Full Text OpenAlex 210 FWCI20.76115088

The pancreatic cancer genome revisited

review Full Text OpenAlex 205 FWCI17.40202794

Targeted therapy for head and neck cancer: signaling pathways and clinical studies

review Full Text OpenAlex 199 FWCI36.94841112