专题：Chromatin Remodeling and Cancer

This cluster of papers focuses on the role of chromatin remodeling, particularly the SWI/SNF complexes and ARID1A mutations, in cancer development and progression. It explores the impact of these mutations on epigenetic regulation, tumor suppression, genomic analysis, oncogenic transformation, and synthetic lethality. Additionally, it delves into the involvement of chromatin remodeling in mammalian development.
最新文献
Multiomics and deep learning dissect regulatory syntax in human development

article Full Text OpenAlex

CREsted: modeling genomic and synthetic cell-type-specific enhancers across tissues and species

article Full Text OpenAlex

BRD9 recognizes lactate-induced H3K18 lactylation to drive oncogenic chromatin remodeling in hepatocellular carcinoma

article Full Text OpenAlex

Acute NIPBL depletion reveals in vivo dynamics of loop extrusion and its role in transcription activation

article Full Text OpenAlex

Extrusion fountains are hallmarks of chromosome organization emerging upon zygotic genome activation

article Full Text OpenAlex

Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome folding

article Full Text OpenAlex

An expanded registry of candidate cis-regulatory elements

article Full Text OpenAlex

PARPs and PARP inhibitors: molecular mechanisms and clinical applications

review Full Text OpenAlex

Interphase chromosome conformation is specified by distinct folding programmes inherited through mitotic chromosomes or the cytoplasm

article Full Text OpenAlex

An integrated view of the structure and function of the human 4D nucleome

article Full Text OpenAlex

近5年高被引文献
Cell cycle regulation: p53-p21-RB signaling

review Full Text OpenAlex 1286 FWCI32.3024

Histone post-translational modifications — cause and consequence of genome function

review Full Text OpenAlex 1114 FWCI23.3089

Targeting DNA damage response pathways in cancer

review Full Text OpenAlex 854 FWCI20.5477

Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

article Full Text OpenAlex 624 FWCI55.5926

High-content CRISPR screening

review Full Text OpenAlex 583 FWCI10.149

Chromatin accessibility profiling by ATAC-seq

review Full Text OpenAlex 555 FWCI11.0821

COSMIC: a curated database of somatic variants and clinical data for cancer

article Full Text OpenAlex 542 FWCI69.2797

Ivosidenib and Azacitidine in IDH1 -Mutated Acute Myeloid Leukemia

article Full Text OpenAlex 526 FWCI80.0232

Signatures of copy number alterations in human cancer

article Full Text OpenAlex 505 FWCI42.934

Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging

article Full Text OpenAlex 505 FWCI33.7309